The central biobank and virtual biobank of BIOMARKAPD : A resource for studies on neurodegenerative diseases
Reijs, Babette L. R. (Maastricht University Medical Center (Països Baixos))
Teunissen, Charlotte E. (Amsterdam University Medical Center (UMC))
Goncharenko, Nikolai (Integrated Biobank of Luxembourg (Luxemburg))
Betsou, Fay (Integrated Biobank of Luxembourg (Luxemburg))
Blennow, Kaj (Sahlgrenska University Hospital (Suècia))
Baldeiras, Inês (University of Coimbra (Portugal))
Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE))
Cavedo, Enrica (Laboratory of Alzheimer's Neuroimaging and Epidemiology)
Fladby, Tormod (University of Oslo (Noruega))
Froelich, Lutz (University of Heidelberg (Alemanya))
Gabryelewicz, Tomasz (Polish Academy of Sciences (Polònia))
Gurvit, Hakan (Istanbul University (Turquia))
Kapaki, Elisabeth N. (National and Kapodistrian University of Athens (Grècia))
Koson, Peter (Slovak Academy of Sciences (Eslovàquia))
Kulic, Luka (University of Zurich (Suïssa))
Lehmann, Sylvain (Université de Montpellier (França))
Lewczuk, Piotr (Medical University of Bialystok (Polònia))
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau)
Maetzler, Walter (University of Tübingen (Alemanya))
de Mendonça, Alexandre (University of Lisbon (Portugal))
Miller, Anne-Marie (Trinity College Dublin)
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Mollenhauer, Brit (University Medical Center Göttingen (Baixa Saxònia))
Parnetti, Lucilla (University of Perugia (Itàlia))
Rot, Uroš (University Medical Centre (Eslovènia))
Schneider, Anja (German Center for Neurodegenerative Diseases (DZNE))
Simonsen, Anja Hviid (Copenhagen University Hospital (Dinamarca))
Tagliavini, Fabrizio (IRCCS Foundation 'Carlo Besta' Neurological Institute (Itàlia))
Tsolaki, Magda (Aristotle University of Thessaloniki (Grècia))
Verbeek, Marcel (Radboud University Medical Centre (Països Baixos))
Verhey, Frans (Maastricht University Medical Center (Països Baixos))
Zboch, Marzena (Wroclaw Medical University (Polònia))
Winblad, Bengt (Karolinska Institutet (Estocolm, Suècia))
Scheltens, Philip (Amsterdam University Medical Center (UMC))
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit))
Visser, Pieter Jelle (Amsterdam University Medical Center (UMC))
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2015
Resum:	Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was to standardize the assessment of existing assays and to validate novel fluid biomarkers for AD and PD. To support the validation of novel biomarkers and assays, a central and a virtual biobank for body fluids and associated data from subjects with neurodegenerative diseases have been established. In the central biobank, cerebrospinal fluid (CSF) and blood samples were collected according to the BIOMARKAPD standardized pre-analytical procedures and stored at Integrated BioBank of Luxembourg. The virtual biobank provides an overview of available CSF, plasma, serum, and DNA samples at each site. Currently, at the central biobank of BIOMARKAPD samples are available from over 400 subjects with normal cognition, mild cognitive impairment (MCI), AD, frontotemporal dementia (FTD), vascular dementia, multiple system atrophy, progressive supranuclear palsy, PD, PD with dementia, and dementia with Lewy bodies. The virtual biobank contains information on over 8,600 subjects with varying diagnoses from 21 local biobanks. A website has been launched to enable sample requests from the central biobank and virtual biobank.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Biobank ; Body fluids ; Cerebrospinal fluid ; Dementia ; Neurodegenerative disorders ; Parkinson's disease
Publicat a:	Frontiers in neurology, Vol. 6 Núm. OCT (2015) , p. 216, ISSN 1664-2295

DOI: 10.3389/fneur.2015.00216
PMID: 26528237

7 p, 160.7 KB

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