Frequency and characteristics of familial melanoma in Spain : The FAM-GEM-1 study
Márquez-Rodas, Iván (Instituto de Investigación Sanitaria Gregorio Marañón (Madrid))
Martín González, Manuel (Hospital Universitario Ramón y Cajal (Madrid))
Nagore, Eduardo (Fundació Institut Valencià d'Oncologia)
Gómez-Fernández, Cristina (Hospital Universitario La Paz (Madrid))
Avilés-Izquierdo, José Antonio (Instituto de Investigación Sanitaria Gregorio Marañón (Madrid))
Maldonado-Seral, Cayetana (Hospital Universitario Central de Asturias)
Soriano, Virtudes (Fundació Institut Valencià d'Oncologia)
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
Palomar, Virginia (Hospital General Universitari de València)
Maseda Pedrero, Rocío (Hospital Universitario La Paz (Madrid))
Martín Carnicero, Alfonso (Hospital San Pedro (Logroño, La Rioja))
Puertolas, Teresa (Hospital Universitario Miguel Servet (Saragossa))
Godoy, Elena (Hospital Universitario de Cabueñes (Gijón))
Cerezuela, Pablo (Hospital General Universitario Santa Lucía (Cartagena, Múrcia))
Ochoa-de-Olza, Maria (Institut Català d'Oncologia)
Campos, Begoña (Hospital Universitario Lucus Augusti (Lugo))
Perez-Ruiz, Elisabeth (Hospital Costa del Sol (Marbella))
Soria, Ainara (Hospital Universitario Ramón y Cajal (Madrid))
Gil-Arnáiz, Irene (Hospital General Universitario Reina Sofía (Múrcia, Múrcia))
González-Cao, María (Hospital Universitari Dexeus (Barcelona, Catalunya))
Galvez, Elisa (Hospital de Elda (Alacant))
Arance, Ana (Hospital Clínic i Provincial de Barcelona)
Belon, Joaquin (Clínica Oncogranada (Granada, Andalusia))
de La Cruz-Merino, Luis (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Martín Algarra, Salvador (Clínica Universidad de Navarra)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	Introduction: Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. Patients and methods: An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. Results: In all, 1047 patients were analyzed, and 69 (6. 6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15. 8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Conclusions: Similar to that observed in other countries, familial melanoma accounts for 6. 6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Female ; Genetic Predisposition to Disease ; Humans ; Incidence ; Male ; Melanoma ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Skin Neoplasms ; Spain
Publicat a:	PloS one, Vol. 10 Núm. 4 (13 2015) , p. e0124239, ISSN 1932-6203

DOI: 10.1371/journal.pone.0124239
PMID: 25874698

8 p, 123.6 KB

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