Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism
Ward, Joey (University of Glasgow (Escòcia))
Le, Ngoc-Quynh (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Suryakant, Suryakant (University of Bordeaux (França))
Brody, Jennifer A. (University of Washington (Estats Units d'Amèrica))
Amouyel, Philippe (University of Lille (França))
Boland, Anne (Laboratory of Excellence in Medical Genomics (França))
Bown, Rosemary (University of Glasgow (Escòcia))
Cullen, Breda Mary (University of Glasgow (Escòcia))
Debette, Stephanie (University of Bordeaux (França))
Deleuze, Jean François (Centre d'Etude du Polymorphisme Humain (França))
Emmerich, Joseph D. (INSERM CRESS (França))
Graham, Nicholas A. (University of Glasgow (Escòcia))
Germain, Marine (University of Bordeaux (França))
Anderson, Jana (University of Glasgow (Escòcia))
Pell, Jill P. (University of Glasgow (Escòcia))
Lyall, Donald M. (University of Glasgow (Escòcia))
Lyall, Laura (Laboratory of Excellence in Medical Genomics (França))
Smith, Daniel J. (University of Edinburgh (Escòcia))
Wiggins, Kerri L. (University of Washington (Estats Units d'Amèrica))
Soria Fernández, José Manuel (Institut d'Investigació Biomèdica Sant Pau)
Souto, Juan Carlos (Institut d'Investigació Biomèdica Sant Pau)
Morange, Pierre-Emmanuel (Aix-Marseille Université)
Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center (Estats Units d'Amèrica))
Trégouët, David-Alexandre (University of Bordeaux (França))
Sabater-Lleal, Maria (Karolinska Institutet (Estocolm, Suècia))
Strawbridge, Rona J. (University of Glasgow (Escòcia))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are associated with an increased risk of cardiovascular diseases, including venous thromboembolism (VTE). The reasons for this are complex and include obesity, smoking, and use of hormones and psychotropic medications. Genetic studies have increasingly provided evidence of the shared genetic risk of psychiatric and cardiometabolic illnesses. This study aimed to determine whether a genetic predisposition to MDD, BD, or SCZ is associated with an increased risk of VTE. Genetic correlations using the largest genome-wide genetic meta-analyses summary statistics for MDD, BD, and SCZ (Psychiatric Genetics Consortium) and a recent genome-wide genetic meta-analysis of VTE (INVENT Consortium) demonstrated a positive association between VTE and MDD but not BD or SCZ. The same summary statistics were used to construct polygenic risk scores for MDD, BD, and SCZ in UK Biobank participants of self-reported White British ancestry. These were assessed for impact on self-reported VTE risk (10 786 cases, 285 124 controls), using logistic regression, in sex-specific and sex-combined analyses. We identified significant positive associations between polygenic risk for MDD and the risk of VTE in men, women, and sex-combined analyses, independent of the known risk factors. Secondary analyses demonstrated that this association was not driven by those with lifetime experience of mental illness. Meta-analyses of individual data from 6 additional independent cohorts replicated the.
Ajuts:	Ministerio de Economía y Competitividad PI15/00269 Instituto de Salud Carlos III PI18/00434
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Blood advances, Vol. 7 Núm. 18 (26 2023) , p. 5341-5350, ISSN 2473-9537

DOI: 10.1182/bloodadvances.2023010562
PMID: 37399490

10 p, 251.9 KB

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