Epidemiology of surgery associated acute kidney injury (EPIS-AKI) : a prospective international observational multi-center clinical study
Zarbock, Alexander (University Hospital Münster (Alemanya))
Weiss, Raphael (University Hospital Münster (Alemanya))
Albert, Felix (University Hospital Münster (Alemanya))
Rutledge, Kristen (University of Alabama)
Kellum, John A. (University of Pittsburgh)
Bellomo, Rinaldo (Monash University)
Grigoryev, Evgeny (Kemerovo Cardiology Centre (Rússia))
Candela-Toha, Angel (Hospital Universitario Ramón y Cajal (Madrid))
Demir, Asli Z. Asli (Ankara Bilkent City Hospital (Turquia))
Legros, Vincent (Centre Hospitalier. Universitaire de Reims)
Rosenberger, Peter (University Hospital Tübingen (Alemanya))
Galán Menéndez, Patricia (Hospital Universitari Vall d'Hebron)
García Álvarez, Mercedes (Institut d'Investigació Biomèdica Sant Pau)
Peng, Ke (First Affiliated Hospital of Soochow University)
Léger, Maxime (Centre Hospitalier Universitaire d'Angers (França))
Khalel, Wegdan (Tripoli Central Hospital (Líbia))
Orhan-Sungur, Mukadder (Istanbul University (Turquia))
Meersch, Melanie (University Hospital Münster (Alemanya))
Makhloufi, Hichem (Constantine Centre Hospitalier Universitaire (Algèria))
Sakhraoui, Rachida (Etablissement Hospitalier Spécialisé Salim Zemirli El Harrach (Algèria))
Ouyahia, Amel A. (Saadna Abdenour Teaching Hospital (Sétif, Algèria))
Rais, Mounira (Saadna Abdenour Teaching Hospital (Sétif, Algèria))
Kouicem, Aya Tinhinane (Saadna Abdenour Teaching Hospital (Sétif, Algèria))
Derwish, Khawla (National Cancer Institute (Londres, Regne Unit))
Abdoun, Meriem (University Hospital of Sétif (Algèria))
Ouahab, Ilhem (University Hospital of Sétif (Algèria))
Bouaoud, Souad (University Hospital of Sétif (Algèria))
Tidjane, Anisse (University Hospital (Orà, Algèria))
Perez Rivera, Carlos J (Universidad El Bosque (Colòmbia))
García, Juan Pablo (Universidad El Bosque (Colòmbia))
Ji, Fuhai (First Affiliated Hospital of Soochow University (Xina))
Ma, Zhengmin (First Affiliated Hospital of Soochow University (Xina))
Sklienka, Peter (University Hospital Ostrava (República Txeca))
Elbahnasawy, Mohamed Gamal (Tanta University Faculty of Medicine (Egipte))
Elsalhawy, Shady (Tanta University Faculty of Medicine (Egipte))
Nafea, Ahmed Mahmoud (Alexandria University Main Hospital (Egipte))
Osman, Nermin A. (Alexandria University (Egipte))
Emara, Moataz Maher (Mansoura University (Egipte))
Bonna, Mohamed Mamdouh (Mansoura University (Egipte))
Abdehaleem, Ibrahim A (Zagazig University Hospital)
Abbas, Ahmed Mohamed (Assiut University Hospitals (Egipte))
Abbas, Mostafa Samy (Assiut University Hospitals (Egipte))
Esmaeil, Hany Mostafa (Assiut University Hospitals (Egipte))
Joannes-Boyau, Olivier (Universitaire de Bordeaux (França))
Floch, Thierry (Centre Hospitalier. Universitaire de Reims (França))
Muccio, Salvatore (Centre Hospitalier. Universitaire de Reims (França))
Menage-Innocenti, Lison (Centre Hospitalier. Universitaire de Reims (França))
Brochet, Benjamin (Centre Hospitalier. Universitaire de Reims (França))
Leclercq-Rouget, Marion (Centre Hospitalier. Universitaire de Reims (França))
Geneve, Claire (Centre Hospitalier. Universitaire de Orléans (França))
Mocarquer, Bernardita Valenzuela (Centre Hospitalier. Universitaire de Orléans (França))
Aveline, Christophe (Hôpital Privé Sévigné (França))
Vautier, Pierre (Hôpital Privé Sévigné (França))
Nadaud, Julien (Hôpital Robert Schuman-Groupe UNEOS (França))
Rimmelé, Thomas (Hôpital Edouard Herriot (França))
Cerro, Valérie (Hôpital Edouard Herriot (França))
Suria, Stéphanie (Gustave Roussy (França))
Elmawieh, Jamie (Gustave Roussy (França))
El-Jawiche, Rita (Gustave Roussy (França))
Cirenei, Cedric (Centre Hospitalier Universitaire de Lille (França))
Lebuffe, Gilles R. (Centre Hospitalier Universitaire de Lille (França))
Ponsonnard, Sebastien (Clinique François Chénieux (França))
Egreteau, Pierre Yves (Centre Hospitalier des Pays de Morlaix (França))
Ichai, Carole R. (Université Côte d'Azur (França))
Jean-Michel, Vanessa (Centre Hospitalier Dron Tourcoing (França))
Lasocki, Sigismond (Centre Hospitalier Universitaire d'Angers (França))
Masson, Charline (Centre Hospitalier Universitaire d'Angers (França))
Rineau, Emmanuel (Centre Hospitalier Universitaire d'Angers (França))
Cassisa, Viviane (Centre Hospitalier Universitaire d'Angers (França))
Verrier, Pierre (Centre François Baclesse (Caen, França))
Atchade, Enora (Hôpital Bichat (França))
Rochon, Charles Edouard (Centre Hospitalier Simone Veil de Blois (França))
Quentin, Vidal (Centre Hospitalier de Bigorre (França))
Queixalos, Nina (Centre Hospitalier Universitaire de Bordeaux (França))
Braun, Thierry (Clinique Sainte Anne (França))
Grand, Hubert (Centre Hospitalier Libourne (França))
Mayeur, Nicolas (Clinique Pasteur (França))
Pasquie, Marie (Clinique Pasteur (França))
Garçon, Pierre (Centre Hospitalier de Marne-La-Vallée (França))
Bruckert, Vincent (Centre Hospitalier. Universitaire de Nice (França))
Pradel, Gaël (Centre Hospitalier Henri Mondor d'Aurillac (França))
Ramorasata, Andersen (Centre Hospitalier Mont de Marsan (França))
Ravry, Céline (Centre Hospitalier de Dax (França))
Mottard, Nicolas (Clinique de la Sauvegarde (França))
Groote, Thilo Von (University Hospital (Alemanya))
Dörr, Christian (University Hospital (Alemanya))
Küllmar, Mira (University Hospital (Alemanya))
Massoth, Christina (University Hospital (Alemanya))
Motekallemi, Arash (University Hospital (Alemanya))
Saadat-Gilani, Khaschayar (University Hospital (Alemanya))
Kerschke, Laura (University Hospital (Alemanya))
Storck, Michael (University of Münster. Institute of Medical Informatics)
Varghese, Julian (University Hospital (Alemanya))
Wempe, Carola (University Hospital(Alemanya))
Grüßer, Linda (University Hospital Aachen (Alemanya))
Kowark, Ana (University Hospital Aachen (Alemanya))
Brandenburger, Timo (University Hospital (Alemanya))
Hohn, Andreas (Kliniken Maria Hilf Mönchengladbach (Alemanya))
Häberle, Helene Anna (University Hospital (Alemanya))
Hofmann, Pascal (University Hospital (Alemanya))
Kuhle, Jonathan (University Hospital (Alemanya))
Calov, Stefanie (University Hospital (Alemanya))
Bernard, Alice Marie (University Hospital (Alemanya))
Mirakaj, Valbona (University Hospital (Alemanya))
Weber, Kathrin (University Hospital (Alemanya))
Pfister, Kathrin (University Hospital (Alemanya))
Stetz, Lena (University Hospital (Alemanya))
Müller, Sarah Dorothea (University Hospital (Alemanya))
Klaus, Stephan (Herz-Jesu-Hospital (Alemanya))
Sadlo, Marco (Herz-Jesu-Hospital (Alemanya))
Sengelhoff, Christian (St. Josef-Stift Sendenhorst (Alemanya))
Stenger, Carina Kristin (Sankt Franziskus Hospital (Alemanya))
Göbel, Ulrich (Sankt Franziskus Hospital (Alemanya))
Heringlake, Matthias (Hosspital Karlsburg (Alemanya))
Arnaoutoglou, Eleni M. (University Hospital Larissa (Grècia))
Stratigopoulou, Panagiota (Laiko General Hospital of Athens (Grècia))
Danai, Pantazi (University Hospital Ioannina (Grècia))
Dimakopoulou, Antonia N. (G. Gennimatas' General Hospital of Athens (Grècia))
Menis, Apostolos Alkiviadis (George Papanicolaou General Hospital (Tessalònica, Grècia))
Ioannidis, Orestis (Aristotle University of Thessaloniki (Grècia))
Jalaawiy, Humam (Al-Diwaniyah Hospital (Iraq))
Anwar, Aeshah (Bagdad Medical City Hospital (Iraq))
Hashim, Hashim Talib (Al-Nassiryah Teaching Hospital (Iraq))
Rasheed Aldawoody, Hogir Imad (Khanaqeen General Hospital (Iraq))
Cortegiani, Andrea (Policlinico Paolo Giaccone (Itàlia))
Ippolito, Mariachiara (Policlinico Paolo Giaccone (Itàlia))
Marino, Claudia (Policlinico Paolo Giaccone (Itàlia))
Presti, Gabriele (Policlinico Paolo Giaccone (Itàlia))
Fricano, Dario Calogero (Policlinico Paolo Giaccone (Itàlia))
De Rosa, Silvia (San Bortolo Hospital (Itàlia))
Bianchin, Andrea (Montebelluna City Hospital (Itàlia))
Paternoster, Gianluca (San Carlo Regional Hospital (Itàlia))
Fasciano, Umberto (San Carlo Regional Hospital (Itàlia))
Cutuli, Salvatore Lucio (Fondazione Policlinico Universitario A. Gemelli IRCCS and Catholic University of the Sacred Heart (Itàlia))
Spadaro, Savino (University of Ferrara (Itàlia))
Bussolati, Enrico (University of Ferrara (Itàlia))
Palmieri, Marco (University of Ferrara (Itàlia))
Volta, Carlo (University of Ferrara (Itàlia))
Tripodi, Vincenzo Francesco (Great Metropolitan Hospital "Bianchi-Melacrino-Morelli" (Itàlia))
Fiume, Diego (Sant'Eugenio Hospital (Itàlia))
Iuorio, Angela (Frangipane Hospital (Itàlia))
Santorsola, Clemente (General Hospital (Itàlia))
Abu-Hussein, Bilal (Al-Basheer Hospital (Jordània))
Hasanein, Khaled (Al-Basheer Hospital (Jordània))
Shin, Seokyung (Yonsei University College of Medicine (Corea del Sud))
Baek, Jongyoon (University Hospital Yeungnam (Corea del Sud))
Kim, Sehui (University Hospital Yeungnam (Corea del Sud))
Elhadi, Muhammed (University of Tripoli (Líbia))
Aldressi, Wafa O. (Benghazi Medical Center (Líbia))
Abuzeid, Issa A. (Benghazi Medical Center (Líbia))
Albaraesi, Mohammed N. (Benghazi Medical Center (Líbia))
Moftah, Mohamed Aziz (Benghazi Medical Center (Líbia))
Aldressi, Sarah (Benghazi Medical Center (Líbia))
Abdulwahed, Eman (Tripoli Central Hospital (Líbia))
Ali Alshareea, Entisar Ahmed (Tripoli Central Hospital (Líbia))
Ashur Abujrad, Akram Abdulhamid (Tripoli Central Hospital (Líbia))
Ghmagh, Reem J. (Tripoli Central Hospital (Líbia))
Biala, Marwa Isa (Tripoli Central Hospital (Líbia))
Islam Benjouira, Rayet Al (National Heart Center (Líbia))
Aliwa, Mohamed (National Heart Center (Líbia))
Msherghi, Ahmed (University Hospital (Líbia))
Tuwaib, Ahmed (University Hospital (Líbia))
Mustafa, Tahani (University Hospital (Líbia))
Zriba, Haifa (University Hospital (Líbia))
Agilla, Hmza Mahmoud (AboSleem Hospital)
Sadek Ben Hamida, Bahaeddin Taher (El-Khadra Hospital (Líbia))
Mohamed Otman, Rema Hassan (El-Khadra Hospital (Líbia))
Mijovska, Maja Mojsova (University Hospital Skopje Mother Theresa (Macedònia))
Camilleri Podesta, Anne Marie (Mater Dei Hospital (Malta))
Gasca López, Gilberto Adrián (Regional Hospital of High Specialty of Ixtapaluca (Mèxic))
Amro, Sarah (Princess Alia Governmental Hospital (Palestina))
de Freitas Regufe, Rita (Hospital São Bernardo (Portugal))
Ivkin, Artem (Kemerovo Cardiology Centre (Rússia))
Balakhnin, Dmitriy (Kemerovo Cardiology Centre (Rússia))
Shukevich, Dmitriy Leonidovich (Kemerovo Cardiology Centre (Rússia))
Yaroustovsky, Michael (A.N. Bakulev National Medical Research Center of Cardiovascular Surgery (Rússia))
Barmou, Abdulnaser (Almana General Hospital (Aràbia Saudita))
Kaserer, Alexander (University Hospital (Xina))
Castellucci, Clara (University Hospital (Suïssa))
Akbas, Samira (University Hospital (Suïssa))
Petrun, Andreja Möller (University Medical Centre Maribor (Eslovènia))
Gregorcic, Irena (University Medical Centre Maribor (Eslovènia))
Sok, Vesna (University Medical Centre Maribor (Eslovènia))
Links, Andre (Stellenbosch University (Sud-àfrica))
Barreto, Elizabeth Bárcena (Hospital Universitario Virgen de las Nieves (Granada))
Melchor, Javier Ripollés (Hospital Universitario Infanta Leonor)
Becerra-Bolaños, Angel (Hospital Universitario de Gran Canaria Dr. Negrín)
Rodriguez-Perez, Aurelio (Hospital Universitario de Gran Canaria Dr. Negrín)
Estévez, Javier Mata (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Matas, Juan Mulet (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Palao, Sara Pérez (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Bainac Albadalejo, Albert (Institut d'Investigació Biomèdica Sant Pau)
Batalla González, Astrid (Institut d'Investigació Biomèdica Sant Pau)
Gómez Caro, Ana Maria (Institut d'Investigació Biomèdica Sant Pau)
Hinojal Blanco, Ignacio (Institut d'Investigació Biomèdica Sant Pau)
Toral Fernandez, Diego (Institut d'Investigació Biomèdica Sant Pau)
Herránz Perez, Gracia (Institut d'Investigació Biomèdica Sant Pau)
Logroño Ejea, Margarita (Hospital Txagorritxu (País Basc))
de la Rosa Ruiz, Noelia (Hospital Txagorritxu (País Basc))
Gastaca Abasolo, María (Hospital Txagorritxu (País Basc))
Ferreira, Lourdes (San Pedro Hospital (Logronyo))
Lobato, Félix (San Pedro Hospital (Logronyo))
Aguado Sevilla, Marta (San Pedro Hospital (Logronyo))
Erazo, Andres (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Castellano Paulis, Berta (University Hospital (País Basc))
dela Calle Gil, Isabel (Hospital 12 de Octubre (Madrid))
Adamove, Peter (Hospital Universitari de Bellvitge)
Blasco Blasco, Francho Miguel (Hospital Universitari de Bellvitge)
García-Sánchez, Jose Ignacio (Hospital Universitario Fundacion Alcorcón)
García Zamorano, Sara (Hospital Universitario Fundacion Alcorcón)
Gijón Herreros, Natalia (Hospital Universitario Fundacion Alcorcón)
Callejas, Raquel (Clinica Universitaria Navarra)
Estaire Gómez, Mercedes (Ciudad Real University Hospital)
Candela-Toha, Angel (Hospital Universitario Ramón y Cajal (Madrid))
Claros-Llamas, Elisabeth (Hospital Universitario Ramón y Cajal (Madrid))
Cobeta-Orduña, Pilar (Hospital Universitario Ramón y Cajal (Madrid))
Crespo-Aliseda, Pascual Agustín (Hospital Universitario Ramón y Cajal (Madrid))
Dorado-Díaz, Trinidad (Hospital Universitario Ramón y Cajal (Madrid))
Gómez-Rojo, Maria (Hospital Universitario Ramón y Cajal (Madrid))
Mané-Ruiz, M. Nuria (Hospital Universitario Ramón y Cajal (Madrid))
Martín-González, Maria Carmen (Hospital Universitario Ramón y Cajal (Madrid))
Martínez-Pérez, Adolfo (Hospital Universitario Ramón y Cajal (Madrid))
Tiscar, Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Estepa Calvo, Verónica (Hospital Universitari Vall d'Hebron)
Llinares Espí, Laura (Hospital Universitari Vall d'Hebron)
Loaiza Aldeán, Yuri Santiago (Hospital Universitari Vall d'Hebron)
Moales Ariza, Víctor (Hospital Universitari Vall d'Hebron)
Villarino Vila, Laura (Hospital Universitari Vall d'Hebron)
García-Miguel, Francisco Javier (La Gerencia de Asistencia Sanitaria de Segovia)
Suliman, Elfayadh Saidahmed Mohamed (Sharg Alneel Hospital and Omdurman Military Hospital)
Ibrahim, Ahmed Mohamed (Gadarif Teaching Hospital)
Fadlalmola, Hammad Ali (Ahmed Gasim Hospital)
Swed, Sarya (Aleppo. Syria Faculty of Medicine)
Wu, Vin-Cent (National Taiwan University Hospital)
Orhan-Sungur, M. (Istanbul University)
Altun, Demet (Istanbul University)
Canbolat, Nur (Istanbul University)
Dinçer, Muserref Beril (Istanbul University)
Aktas Yildirim, Serap (Acibadem Mehmet Ali Aydinlar University School of Medicine)
Iyigun, Müzeyyen (Acibadem Mehmet Ali Aydinar University School of Medicine)
Yapıcı, Davud (Mersin University)
Özdemir, Levent (Mersin University)
Sagün, A. (Mersin University)
Boztug, N. (Akdeniz University)
Gündüz, E. (Akdeniz University)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is unclear. We conducted an international prospective, observational, multi-center study in 30 countries in patients undergoing major surgery (> 2-h duration and postoperative intensive care unit (ICU) or high dependency unit admission). The primary endpoint was the occurrence of PO-AKI within 72 h of surgery defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary endpoints included PO-AKI severity and duration, use of renal replacement therapy (RRT), mortality, and ICU and hospital length of stay. We studied 10,568 patients and 1945 (18. 4%) developed PO-AKI (1236 (63. 5%) KDIGO stage 1500 (25. 7%) KDIGO stage 2209 (10. 7%) KDIGO stage 3). In 33. 8% PO-AKI was persistent, and 170/1945 (8. 7%) of patients with PO-AKI received RRT in the ICU. Patients with PO-AKI had greater ICU (6. 3% vs. 0. 7%) and hospital (8. 6% vs. 1. 4%) mortality, and longer ICU (median 2 (Q1-Q3, 1-3) days vs. 3 (Q1-Q3, 1-6) days) and hospital length of stay (median 14 (Q1-Q3, 9-24) days vs. 10 (Q1-Q3, 7-17) days). Risk factors for PO-AKI included older age, comorbidities (hypertension, diabetes, chronic kidney disease), type, duration and urgency of surgery as well as intraoperative vasopressors, and aminoglycosides administration. In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate that PO-AKI represents a significant burden for health care worldwide.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acute kidney injury ; Epidemiology ; Mortality ; Perioperative ; Postoperative
Publicat a:	Intensive Care Medicine, Vol. 49 Núm. 12 (december 2023) , p. 1441-1455, ISSN 1432-1238

DOI: 10.1007/s00134-023-07169-7
PMID: 37505258

14 p, 1.2 MB

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