SCORE2-Diabetes : 10-year cardiovascular risk estimation in type 2 diabetes in Europe
Pennells, Lisa Anne (University of Cambridge (Cambridge. Regne Unit))
Kaptoge, Stephen (University of Cambridge (Cambridge, Regne Unit))
Østergaard, Helena Bleken (Utrecht University (Utrecht, Països Baixos))
Read, Stephanie H. (University of Edinburgh (Edinburgh, Escòcia))
Carinci, Fabrizio (University of Bologna (Bolonya, Itàlia))
Franch-Nadal, Josep (Institur Català de la Salud (Barcelona, Catalunya))
Petitjean, Carmen (University of Cambridge (Cambridge, Regne Unit))
Taylor, Owen (University of Cambridge (Cambridge, Regne Unit))
Hageman, Steven H. J. (Utrecht University (Utrecht, Països Baixos))
Xu, Zhe (University of Cambridge (Cambridge, Regne Unit))
Shi, Fanchao (University of Cambridge (Cambridge, Regne Unit))
Wild, Sarah (University of Cambridge (Cambridge, Regne Unit))
Gualdi, Stefano (Internet Express (Pescara, Itàlia))
Holman, Naomi (Imperial College London (Londres, Regne Unit))
Providência, Rui (University College London (Londres, Regne Unit))
Bonnet, Fabrice (University of Rennes 1. Rennes CHU (Rennes, França))
Brenner, Hermann (German Cancer Research Center (DKFZ))
Gillum, Richard Frank (Howard University Hospital (Washington, Estats Units d'Amèrica))
Kiechl, Stefan (Medical University Innsbruck (Innsbruck, Àustria))
Lawlor, Deborah A. (University of Bristol (Bristol, Regne Unit))
Potier, Louis (Universite Paris City (París, França))
Schöttker, Ben (German Cancer Research Center (DKFZ))
Sofat, Reecha (University College London (Londres, Regne Unit))
Völzke, Henry (University Medicine Greifswald (Greifswald, Alemanya))
Willeit, Johann (Medical University Innsbruck (Innsbruck, Àustria))
Baltane, Zane (Centre for Disease Prevention and Control of Latvia (Riga, Letònia))
Fava, Stephen (University of Malta (Msida, Malta))
Janos, Sándor (Általános Orvostudományi Kar (Debrecen, Hongria))
Lavens, Astrid (Sciensano (Brussel·les, Bèlgica))
Pildava, Santa (Croatian Institute of Public Health (Riga, Letònia))
Poljicanin, Tamara (Central University of Catalonia (Barcelona, Catalunya))
Pristas, Ivan (Central University of Catalonia (Barcelona, Catalunya))
Rossing, Peter (Steno Diabetes Center Copenhagen (Copenhaguen, Dinamarca))
Sascha, Reiff (Ministry of Health (Malta))
Scheidt-Nave, Christa (Robert Koch Institute (Berlí, Alemanya))
Stotl, Iztok (University Medical Centre Ljubljana (Ljubljana, Eslovènia))
Tibor, Gail (University of Debrecen (Debrecen, Hongria))
Urbančič-Rovan, Vilma (University Medical Centre Ljubljana (Ljubljana, Eslovènia))
Vanherwegen, An Sofie (Sciensano (Brussel·les, Bèlgica))
Vistisen, Dorte (Steno Diabetes Center Copenhagen (Copenhaguen, Dinamarca))
Du, Yong (Robert Koch Institute (Berlí, Alemanya))
Walker, Matthew R. (University of Cambridge (Cambridge, Regne Unit))
Willeit, Peter (Medical University of Innsbruck (Innsbruck, Àustria))
Ference, Brian A. (University of Cambridge (Cambridge, Regne Unit))
De Bacquer, Dirk (Ghent University (Gant, Bèlgica))
Halle, Martin (University Hospital LKlinikum rechts der Isar L. Technical University of Munich (Munich, Alemanya))
Huculeci, Radu (European Society of Cardiology (Brussel·les, Bèlgica))
Mcevoy, John (National University of Ireland Galway (Galway, Irlanda))
Timmis, Adam (Queen Mary University of London (Londres, Regne Unit))
Vardas, Panagiotis (University Hospital of Heraklion (Heraklion, Grècia))
Dorresteijn, Jannick (Utrecht University (Utrecht, Països Baixos))
Graham, Ian (University of Dublin (Dublí, Irlanda))
Wood, Angela (University of Cambridge (Cambridge, Regne Unit))
Eliasson, Björn (Sahlgrenska University Hospital (Gothenburg, Suècia))
Herrington, William (University of Oxford)
Danesh, John N. (University of Cambridge (Cambridge, Regne Unit))
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Massi-Benedetti, Massimo (Hub for International Health Research (Perugia, Itàlia))
Sattar, Naveed (University of Glasgow (Glasgow, escòcia))
Visseren, Frank L. J. (Utrecht University (Utrecht, Països Baixos))
Wild, Sarah H. (University of Edinburgh (Edinburgh, Escòcia))
Di Angelantonio, Emanuele (Health Data Science Centre. Human Technopole (Milà, Itàlia))
Balkau, Beverley (Centre de Recherche en Épidémiologie et Santé des Populations (Villejuif, França))
Fumeron, Frederic (Institut Necker-Enfants Malades (París, França))
Stocker, H.
Holleczek, B.
Schipf, S.
Schmidt, C.O.
Dörr, Marcus
Tilg, H.
Leitner, C.
Notdurfter, M.
Taylor, J.
Dale, C.
Prieto-Merino, D.
Buble, T.
Ivanko, P.
Carstensen, B.
Heidemann, C.
Lepiksone, J.
Magri, C.J.
Azzopardi, J.
Real, J.
Vlacho, Bogdan
Mata-Cases, Manel
Universitat Autònoma de Barcelona

Data:	2023
Resum:	To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 460 participants (43 706 CVD events) with type 2 diabetes and without previous CVD. Sex-specific competing risk-adjusted models were used including conventional risk factors (i. e. age, smoking, systolic blood pressure, total, and HDL-cholesterol), as well as diabetes-related variables (i. e. age at diabetes diagnosis, glycated haemoglobin [HbA1c] and creatinine-based estimated glomerular filtration rate [eGFR]). Models were recalibrated to CVD incidence in four European risk regions. External validation included 217 036 further individuals (38 602 CVD events), and showed good discrimination, and improvement over SCORE2 (C-index change from 0. 009 to 0. 031). Regional calibration was satisfactory. SCORE2-Diabetes risk predictions varied several-fold, depending on individuals' levels of diabetes-related factors. For example, in the moderate-risk region, the estimated 10-year CVD risk was 11% for a 60-year-old man, non-smoker, with type 2 diabetes, average conventional risk factors, HbA1c of 50 mmol/mol, eGFR of 90 mL/min/1. 73 m2, and age at diabetes diagnosis of 60 years. By contrast, the estimated risk was 17% in a similar man, with HbA1c of 70 mmol/mol, eGFR of 60 mL/min/1. 73 m2, and age at diabetes diagnosis of 50 years. For a woman with the same characteristics, the risk was 8% and 13%, respectively. SCORE2-Diabetes, a new algorithm developed, calibrated, and validated to predict 10-year risk of CVD in individuals with type 2 diabetes, enhances identification of individuals at higher risk of developing CVD across Europe.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cardiovascular diseases ; Diabetes ; Prediction model
Publicat a:	European heart journal, Vol. 44 Núm. 28 (july 2023) , p. 2544-2556, ISSN 1522-9645

DOI: 10.1093/eurheartj/ehad260
PMID: 37247330

14 p, 1.0 MB

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