Calibration of a three-state cell death model for cardiomyocytes and its application in radiofrequency ablation
Petras, Argyrios (Austrian Academy of Sciences)
Leoni, Massimiliano (Austrian Academy of Sciences)
Guerra Ramos, José María (Institut d'Investigació Biomèdica Sant Pau)
Gerardo-Giorda, Luca (Johannes Kepler University)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Thermal cellular injury follows complex dynamics and subcellular processes can heal the inflicted damage if insufficient heat is administered during the procedure. This work aims to the identification of irreversible cardiac tissue damage for predicting the success of thermal treatments. Several approaches exist in the literature, but they are unable to capture the healing process and the variable energy absorption rate that several cells display. Moreover, none of the existing models is calibrated for cardiomyocytes. We consider a three-state cell death model capable of capturing the reversible damage of a cell, we modify it to include a variable energy absorption rate and we calibrate it for cardiac myocytes. We show how the thermal damage predicted by the model response is in accordance with available data in the literature on myocytes for different temperature distributions. When coupled with a computational model of radiofrequency catheter ablation, the model predicts lesions in agreement with experimental measurements. We also present additional experiments (repeated ablations and catheter movement) to further illustrate the potential of the model. We calibrated a three-state cell death model to provide physiological results for cardiac myocytes. The model can be coupled with ablation models and reliably predict lesion sizes comparable to experimental measurements. Such approach is robust for repeated ablations and dynamic catheter-cardiac wall interaction, and allows for tissue remodelling in the predicted damaged area, leading to more accurate in-silico predictions of ablation outcomes.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cardiomyocytes ; Computer simulation ; Radiofrequency ablation ; Thermal damage
Publicado en:	Physiological Measurement, Vol. 44 Núm. 6 (january 2023) , p. 65003, ISSN 1361-6579

DOI: 10.1088/1361-6579/acdcdd
PMID: 37290447

12 p, 1.4 MB

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