Prevalence and Factors Associated with Drooling in Parkinson's Disease : Results from a Longitudinal Prospective Cohort and Comparison with a Control Group
Santos García, Diego (Complejo Hospitalario Universitario de A Coruña)
De Deus Fonticoba, T. (Complejo Hospitalario Universitario de Ferrol)
Cores Bartolomé, C. (Complejo Hospitalario Universitario de A Coruña)
Feal Painceiras, M.J. (Complejo Hospitalario Universitario de A Coruña)
Íñiguez Alvarado, María Cristina (Complejo Hospitalario Universitario de A Coruña)
Jesús Maestre, Silvia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Buongiorno, M.T. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Planellas, L. (Clínica Del Pilar)
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona)
García Caldentey, J. (Centro Neurológico Oms 42)
Caballol, N. (Hospital de Sant Joan Despí Moisès Broggi)
Legarda, I. (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron)
Cabo, I. (Complejo Hospitalario Universitario de Pontevedra)
López Manzanares, L. (Hospital Universitario de la Princesa (Madrid))
González Aramburu, I. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Ávila Rivera, Maria A (Hospital General de ĹHospitalet)
Gómez Mayordomo, V. (Hospital Universitario Clínico San Carlos (Madrid))
Nogueira, V. (Hospital Da Costa Burela)
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya))
Dotor García-Soto, J. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Borrué, C. (Hospital Universitario Infanta Sofía)
Solano Vila, B. (Institut Català de la Salut)
Álvarez Sauco, María (Hospital General Universitario de Elche)
Vela, L. (Hospital Universitario Fundación Alcorcón)
Escalante, S. (Hospital de Tortosa Verge de la Cinta)
Cubo, Esther (Complejo Asistencial Universitario de Burgos)
Carrillo Padilla, F. (Hospital Universitario de Canarias (La Laguna))
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Sánchez Alonso, P. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Alonso Losada, M.G. (Hospital Álvaro Cunqueiro (Vigo))
López Ariztegui, Nuria (Complejo Hospitalario de Toledo)
Gastón, I. (Complejo Hospitalario de Navarra)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Blázquez Estrada, Marta (Hospital Universitario Central de Asturias)
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra)
Rúiz Martínez, J. (Hospital de Donostia (Sant Sebastià, País Basc))
Valero, C. (Hospital Arnau de Vilanova (València))
Kurtis, M. (Hospital Ruber Internacional)
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron)
González Ardura, J. (Hospital Universitario de Cabueñes (Gijón))
Alonso Redondo, R. (Universitario Lucus Augusti (HULA))
Ordás Bandera, Carlos Manuel (Hospital Universitario Rey Juan Carlos (Madrid))
López Díaz, L.M.L. (Complexo Hospitalario Universitario de Ourense - CHUO)
McAfee, D. (University of Maryland)
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Coppadis, S.G. (Fundación Degen)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Drooling in Parkinson's disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. The frequency of drooling in PD patients was 40. 1% (277/691) at V0 (2. 4% (5/201) in controls; p < 0. 0001), 43. 7% (264/604) at V1, and 48. 2% (242/502) at V2 (3. 2% (4/124) in controls; p < 0. 0001), with a period prevalence of 63. 6% (306/481). Being older (OR = 1. 032; p = 0. 012), being male (OR = 2. 333; p < 0. 0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1. 020; p < 0. 0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1. 012; p < 0. 0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64. 6% and a higher score on the UPDRS-III at V0 (OR = 1. 121; p = 0. 007) as a predictor of drooling at V2. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.
Ajuts:	Ministerio de Economía y Competitividad PI16/01575
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Parkinson's Disease, Vol. 2023 (2023) , p. 3104425, ISSN 2042-0080

DOI: 10.1155/2023/3104425
PMID: 37065970

18 p, 374.6 KB

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