Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors
Menéndez, Rosario (Universitat de València)
Méndez, Raúl (Universitat de València)
Latorre, Ana (Instituto de Investigación Sanitaria La Fe (IISLAFE))
González-Jiménez, Paula (Universitat de València)
Peces-Barba, Germán (Hospital Universitario Fundación Jiménez Díaz)
Molina Molina, Maria (Hospital Universitari de Bellvitge)
España, Pedro Pablo (Hospital de Galdakao (Usansolo, Biscaia))
García, Estela (Hospital Universitario de Cabueñes (Gijón))
Consuegra-Vanegas, Angélica (Hospital Universitario de A Coruña)
Pando-Sandoval, Ana (Hospital Universitario Central de Asturias)
Panadero, Carolina (Hospital de Getafe)
Figueira-Gonçalves, Juan Marco (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
De la Rosa, David (Institut d'Investigació Biomèdica Sant Pau)
Sibila, Oriol (Hospital Clínic i Provincial de Barcelona)
Martínez-Pitarch, María Dolores (Hospital Lluís Alcanyís de Xàtiva)
Toledo, Nuria (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Cejudo, Pilar (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Almonte-Batista, Wanda (Complejo Hospitalario Universitario de Albacete)
Macías-Paredes, Abigail (Hospital de Sant Jaume)
Badenes-Bonet, Diana (Hospital del Mar (Barcelona, Catalunya))
Pérez-Rodas, Eli Nancy (Hospital Dos de Maig (Barcelona, Catalunya))
Lázaro, Javier (Hospital Royo Villanova)
Quirós, Sarai (Hospital Universitario de Basurto (Bilbao, Biscaia))
Cordovilla, Rosa (Hospital Universitario de Salamanca)
Cano-Pumarega, Irene (Hospital Universitario Ramón y Cajal (Madrid))
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year follow-up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D) at 1-year follow-up in patients from the Spanish Registry RECOVID. RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits. Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced D. Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72. 2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO/FiO <450 or CURB-65 ≥2. Reduced D was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO/FiO <450 and CURB-65 ≥2 and the requirement of respiratory support. At 12 months, a proportion of the asymptomatic patients showed reduced D (9. 5%), radiological findings (25%) or both (11%). The factors associated with symptom persistence, incomplete radiological resolution and D <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced D and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; RECOVID ; SARS-CoV-2 ; SEPAR
Publicat a:	Journal of Internal Medicine, Vol. 294 Núm. 1 (july 2023) , p. 69-82, ISSN 1365-2796

DOI: 10.1111/joim.13642
PMID: 37038609

14 p, 1.1 MB

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