Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors
Menéndez, Rosario (Universitat de València)
Méndez, Raúl (Universitat de València)
Latorre, Ana (Institut d'Investigació Sanitària La Fe (València))
González-Jiménez, Paula (Universitat de València)
Peces-Barba, Germán (Hospital Universitario Fundación Jiménez Díaz)
Molina Molina, Maria (Hospital Universitari de Bellvitge)
España, Pedro Pablo (Hospital de Galdakao (Usansolo, Biscaia))
García, Estela (Hospital Universitario de Cabueñes (Gijón))
Consuegra-Vanegas, Angélica (Hospital Universitario de A Coruña)
Pando-Sandoval, Ana (Hospital Universitario Central de Asturias)
Panadero, Carolina (Hospital de Getafe)
Figueira-Gonçalves, Juan Marco (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau)
Sibila, Oriol (Hospital Clínic i Provincial de Barcelona)
Martínez-Pitarch, María Dolores (Hospital Lluís Alcanyís de Xàtiva)
Toledo, Nuria (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Cejudo, Pilar (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Almonte-Batista, Wanda (Complejo Hospitalario Universitario de Albacete)
Macías-Paredes, Abigail (Hospital de Sant Jaume)
Badenes-Bonet, Diana (Hospital del Mar (Barcelona, Catalunya))
Pérez-Rodas, Eli Nancy (Hospital Dos de Maig (Barcelona, Catalunya))
Lázaro, Javier (Hospital Royo Villanova)
Quirós, Sarai (Hospital Universitario de Basurto (Bilbao, Biscaia))
Cordovilla, Rosa (Hospital Universitario de Salamanca)
Cano Pumarega, Irene (Hospital Universitario Ramón y Cajal (Madrid))
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year follow-up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D) at 1-year follow-up in patients from the Spanish Registry RECOVID. RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits. Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced D. Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72. 2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO/FiO <450 or CURB-65 ≥2. Reduced D was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO/FiO <450 and CURB-65 ≥2 and the requirement of respiratory support. At 12 months, a proportion of the asymptomatic patients showed reduced D (9. 5%), radiological findings (25%) or both (11%). The factors associated with symptom persistence, incomplete radiological resolution and D <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced D and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; RECOVID ; SARS-CoV-2 ; SEPAR
Publicat a:	Journal of Internal Medicine, Vol. 294 Núm. 1 (july 2023) , p. 69-82, ISSN 1365-2796

DOI: 10.1111/joim.13642
PMID: 37038609

14 p, 1.1 MB

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