High prevalence of venous thrombotic events in Cushing's syndrome : data from ERCUSYN and details in relation to surgery
Isand, Kristina (University of Tartu (Estonia))
Feelders, Richard (Erasmus University Medical Centre (Holanda))
Brue, Thierry (Aix-Marseille Université)
Toth, Miklos (Semmelweis University (Budapest, Hongria))
Deutschbein, Timo (Julius-Maximilians-Universität Würzburg)
Reincke, Martin (Ludwig-Maximilians-Universität München)
Krsek, Michael (University Hospital Kralovske Vinohrady (Praga, República Txeca))
Santos, Alicia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Demtröder, Frank (Zentrum für Endokrinologie, Diabetologie, Rheumatologie Dr. Demtröder & Kollegen (Dormund, Alemanya))
Chabre, Olivier (Hospitalier Universitaire (Grenoble, França))
Strasburger, Christian J. (Charité-Universitätsmedizin Berlin)
Aulinas, Anna (Institut de Recerca Sant Pau)
Volke, Vallo (University of Tartu (Estonia))
Pereira, Alberto M. (University of Amsterdam)
Lohmann, Rüdiger (Health Care Consulting GmbH. Lohmann & Birkner Health Care Consulting GmbH (Berlin, Alemanya))
Gich, Ignasi (Institut de Recerca Sant Pau)
Webb, S. M. 1952- (Institut de Recerca Sant Pau)
Wass, John (Oxford University Hospitals)
Valassi, Elena (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Amaral, Cláudia (Centro Hospitalar do Porto-Hospital Santo António)
Ambrogio, A. (University of Milan)
Aranda, G. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Arosio, M. (University of Milan)
Balomenaki, M. (Evangelismos General Hospital (Grècia))
Beck-Peccoz, P. (University of Milan)
Berr-Kirmair, C. (Ludwig-Maximilians-Universität München)
Bertherat, Jérôme (Hôpital Cochin (París, França))
Bolanowski, M. (Wroclaw Medical University)
Bollerslev, J. (University in Oslo)
Cardoso, H. (Centro Hospitalar do Porto-Hospital Santo António)
Carvalho, D. (Hospital de San Joao)
Cavagnini, F. (University of Milan)
Ceccato, P. (University-Hospital of Padova)
Chanson, Philippe (Service de Endocrinologie et des Maladies de la Reproduction)
Christ, E. (University Hospital of Bern. Inelspital. Division of Endocrinology. Diabetology and Clinical Nutrition Partner und Klinikum Dortmund)
Denes, J. (2nd Department of Medicine. State Health Center)
Dimopoulou, C. (Max-Planck-Gessellschaft zur Forderung der Wissenschaften e.V.)
Dreval, A. (Moscow Regional Research Clinical Institute n.a. Vladimirsky)
Droste, M. (Praxis für Endokrinologie Droste)
Duarte, J.S. (Serviço Endocrinologia CHLO. Hospital Egas Moniz)
Dusek, T. (Department of Endocrinology. University Hospital Zagreb. School of Medicine University of Zagreb)
Ertürk, E. (Uludag University School of Medicine)
Evang, J.A. (Section of Specialized Endocrinology. Oslo University Hospital. Faculty of Medicine. University in Oslo)
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València))
Fazel, J. (Medizinische Klinik und Poliklinik IV. Campus Innenstadt. Klinikum der Universität München. Ludwig-Maximilians-Universität München)
Fica, S. (Elias Hospital)
García-Centeno, R. (Hospital General Universitario Gregorio Marañón)
Ghigo, E. (Molinette Hospital. Department of Internal Medicine)
Goth, M. (State Health Center (Budapest, Hongria))
Greenman, Y. (Institute of Endocrinology. Metabolism and Hypertension)
Halperin, I. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Hanzu, F.A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Hermus, A. (Radboud University Medical Center)
Johannsson, Gudmundur (University of Gothenburg)
Hubina, E. (State Health Center (Budapest, Hongria))
Kamenicky, P. (Institut National de la Santé et de la Recherche Médicale U1185. Le Kremlin Bicêtre)
Kasperlik-Zaluska, A. (Centre for Postgraduate Medical Education)
Kirchner, J. (Division of Clinical Endocrinology. Department of Medicine CCM. Charité-Universitätsmedizin)
Kastelan, D. (Department of Endocrinology. University Hospital Zagreb)
Komerdus, I. (Moscow Regional Research Clinical Institute n.a. Vladimirsky)
Kraljevic, I. (Department of Endocrinology. University Hospital Zagreb)
Kruszynska, A. (Centre for Postgraduate Medical Education)
Lamas, C. (Complejo Hospitalario Universitario de Albacete)
Lambrescu, I. (Elias Hospital)
Lang, S. (Max-Planck-Gessellschaft zur Forderung der Wissenschaften e.V.)
Luger, A. (Medizinische Universität Wien)
Maiter, D. (UCL Cliniques Universitaires St Luc)
Marpole, N. (Christie Hospital. NHS Trust)
Martín Alegre, Sara (Elias Hospital)
Martinie, M. (Service d'Endocrinologie-Diabétologie Nutrition)
Oliveira, M.J.M. (Centro Hospitalar Vila Nova Gaia/Espinho)
Moros, O. (Eberhard & Partner und Klinikum Dortmund)
Netea-Maier, R. (Radboud University Nijmegen Medical Centre)
Newell-Price, J. (The University of Sheffield)
Orbetzova, M. ("Sv. Georgy" University Hospital)
Paiva, I. (Hospitais da Universidade de Coimbra)
Giraldi, F.P. (Istituto Auxologico Italiano IRCCS. University of Milan)
Percovich, J.C. (Hospital General Universitario Gregorio Marañón)
Pfeiffer, M. (Klinicni Center)
Pickel, J. (Max-Planck-Gessellschaft zur Forderung der Wissenschaften e.V.)
Pirags, V. (Paul Stradins Clinical University Hospital ( Letonia))
Ragnarsson, O. (Goteborg University)
Reghina, A.D. (Elias Hospital)
Riesgo, P. (Hospital Universitari de la Ribera (València))
Roberts, M. (Christie Hospital. NHS Trust)
Roerink, S. (Radboud University Medical Center)
Rowan, C. (Christie Hospital. NHS Trust)
Rudenko, P. (Estonian Endocrine Society)
Sahnoun, M.A. (APHM. Hôpital Conception)
Salvador, J. (Universidad Pública de Navarra)
Scaroni, Carla (Hospital-University of Padova)
Sigurjonsdottir, H.A. (Faculty of Medicine. University of Iceland)
Polovina, T.S. (Department of Endocrinology. University Hospital Zagreb)
Smith, R. (Oxford Radcliffe Hospitals NHS Trust)
Stachowska, B. (Department of Endocrinology. Diabetology and Isotope Therapy Wroclaw Medical University)
Stalla, G. (Max-Planck-Gessellschaft zur Forderung der Wissenschaften e.V.)
Tabarin, Antoine (Department of Endocrinology. Diabetes and Nutrition. University of Bordeaux)
Terzolo, M. (Internal Medicine-Endocrinology. San Luigi Hospital)
Tőke, J. (2nd Departement of Medicine. Semmelweis University)
Touraine, P. (Hôpital Pitié-Salpêtière (París, França))
Trainer, P.J. (Department of Endocrinology. Christie Hospital)
Tsagarakis, S. (Athens Polyclinic General Hospital. Evangelismos Hospital)
Vila, G. (Medizinische Universität Wien)
Vinay, S. (Christie Hospital. NHS Trust)
Wagenmakers, Margreet (Radboud University Medical Center)
Werner, S. (Praxis für Endokrinologie Droste)
Young, Jacques (Institut National de la Santé et de la Recherche Médicale U1185. Le Kremlin Bicêtre)
Zdunowski, P. (Centre for Postgraduate Medical Education)
Zacharieva, Sabina (Medical University of Sofia)
Zopf, K. (Division of Clinical Endocrinology. Department of Medicine CCM. Charité-Universitätsmedizin)
Zopp, S. (Medizinische Klinik und Poliklinik IV. Campus Innenstadt. Klinikum der Universität München. Ludwig-Maximilians-Universität München)
Zosin, I. (Romanian Society for Endocrinology)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Objective: The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. Design: A retrospective observational cohort study. Methods: Data extraction from the registry was taken on February, 7, 2022. At the time there were 2174 patients diagnosed with Cushing's syndrome (CS) and 95 VTEs were reported in the database. Results: Of 95 VTE events 70 (74%) were in pituitary-dependent CS patients, 12 (12. 5%) in adrenal-dependant CS, 10 (10. 5%) in ectopic CS, and 3 (3%) in CS due to other causes. Sex, 24-hour urinary free cortisol (UFC) value at diagnosis, as well as the number of operations remained statistically significant predictors of VTE. Of patients who were treated with at least one surgery, 12 (13%) VTE occurred before and 80 (87%) after the surgery. Nearly half of these VTEs occurred within six months since the operation (36; 45%). Over half of the centers that reported VTE did not routinely anticoagulate CS patients. Anticoagulation schemes varied widely. Conclusion: Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cushing's syndrome ; Venous thromboembolism ; Risk factors ; ERCUSYN
Publicat a:	European journal of endocrinology, Vol. 190 Núm. 1 (january 2024) , p. 75-85, ISSN 1479-683X

DOI: 10.1093/ejendo/lvad176
PMID: 38146835

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