Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain : a prospective population-based screening study
Roure, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vallès, Xavier (Institut Germans Trias i Pujol)
Pérez-Quílez, Olga (Instituto Catalán de la Salut)
López-Muñoz, Israel (Instituto Catalán de la Salut)
Chamorro, Anna (Fundació Lluita contra les Infeccions (Badalona, Barcelona))
Abad, Elena (Fundació Lluita contra les Infeccions (Badalona, Barcelona))
Valerio, Lluís (Fundació Lluita contra les Infeccions (Badalona, Barcelona))
Soldevila Langa, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
España Cueto, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hegazy, Alaa H. A. (University of Asyut (El Fateh, Egipte))
Fernandez Rivas, Gema (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Gorriz, Ester (Instituto Catalán de la Salut)
Herena, Dolores (Instituto Catalán de la Salut)
Oliveira, Mario (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Miralles, Maria Carme (Instituto Catalán de la Salut)
Conde, Carmen (Instituto Catalán de la Salut)
Montero-Alia, Juan José (Instituto Catalán de la Salut)
Fernández-Pedregal, Elia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Miranda-Sánchez, José (Instituto Catalán de la Salut)
Llibre Codina, Josep Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Isnard, Mar (Institut Català de la Salut)
Bonet Simó, Josep Maria (Institut Català de la Salut)
Estrada Cuxart, Oriol (Institut Català de la Salut)
Prat Gil, Nuria (Institut Català de la Salut)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)

Data:	2024
Resum:	Background: Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology test. Methods: We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in Spain. Schistosoma serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured questionnaire. Results: We included 388 adult males, mean age 43. 5 years [Standard Deviation (SD) = 12. 0, range: 18-76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11-21] years. The most frequent country of origin was Senegal (N = 179, 46. 1%). Of the 338, 147 (37. 6%) tested positive for Schistosoma. Parasite eggs were present in the urine of only 1. 3%. Nine genitourinary clinical items were significantly associated with positive Schistosoma serology results: pelvic pain (45. 2%; OR = 1. 57, 95% CI: 1. 0-2. 4), pain on ejaculation (14. 5%; OR = 1. 85, 95% CI: 1. 0-3. 5), dyspareunia (12. 4%; OR = 2. 45, 95% CI: 1. 2-5. 2), erectile dysfunction (9. 5%; OR = 3. 10, 95% CI: 1. 3-7. 6), self-reported episodes of infertility (32. 1%; OR = 1. 69, 95% CI: 1. 0-2. 8), haematuria (55. 2%; OR = 2. 37, 95% CI: 1. 5-3. 6), dysuria (52. 1%; OR = 2. 01, 95% CI: 1. 3-3. 1), undiagnosed syndromic STIs (5. 4%), and orchitis (20. 7%; OR = 1. 81, 95% CI: 1. 0-3. 1). Clinical signs tended to cluster. Conclusions: Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positive Schistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to chronic schistosomiasis. Graphical Abstract: (Figure presented. ).
Nota:	We are greatly indebted to the primary health centre professionals at participating locations as well as to the participants themselves. Schisto-Stop study group : Montserrat Riera, Núria Rovira, Ainhoa López, Mayra Segura, Susana Escoda, Janeth Karin Villalaz-Gonzales, Maria Jesús Delgado, Iciar Ferre-García, Sandra Santamaria, Marilen Matero.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Infectious Diseases of Poverty, Vol. 13 Núm. 1 (december 2024) , p. 23, ISSN 2049-9957

DOI: 10.1186/s40249-024-01190-8
PMID: 38449032

10 p, 1.6 MB

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