Comparing R-Bendamustine vs. R-CHOP Plus Maintenance Therapy as First-Line Systemic Treatment in Follicular Lymphoma : A Multicenter Retrospective GELTAMO Study
Bastos, Mariana (Hospital General Universitario Gregorio Marañón)
Gutiérrez, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Cabero, Almudena (Hospital Clínico Universitario (Salamanca))
López, Javier (Hospital Universitario Ramón y Cajal (Madrid))
Villafuerte, Paola (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Jiménez-Ubieto, Ana (Hospital 12 de Octubre (Madrid))
de Oña, Raquel (Anderson Cancer Center (Madrid))
De la Fuente, Adolfo (Anderson Cancer Center (Madrid))
Navarro, Belén (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Peñalver, Javier (Hospital Universitario Fundación Alcorcón)
Martínez-Barranco, Pilar (Hospital Universitario Fundación Alcorcón)
Alonso, Carmen (Hospital Arnau de Villanova)
Infante, María (Hospital Universitario Infanta Leonor)
Córdoba, Raúl (Hospital Universitario Fundación Jiménez Díaz)
Perez-Montero, Blanca (Hospital Universitario HM Sanchinarro (Madrid))
Perez de Oteyza, Jaime (Hospital Universitario HM Sanchinarro (Madrid))
González de Villambrosio, Sonia (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Fernández-Caldas, Paula (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
del Campo, Raquel (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Garcia-Belmonte, Daniel (Hospital de La Zarzuela)
Diaz-Gálvez, Javier (Hospital Universitario de Burgos)
Salar Silvestre, Antonio (Hospital del Mar (Barcelona, Catalunya))
Sancho, Juan-Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2024
Resum:	Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and R-bendamustine (R-B) are the most common frontline treatment strategies for advanced-stage follicular lymphoma (FL). After R-CHOP induction therapy, using rituximab for maintenance therapy notably improves outcomes; however, whether this can be achieved by using the same approach after R-B therapy is still being determined. This retrospective analysis compared 476 FL patients from 17 GELTAMO centers who received R-based regimens followed by rituximab maintenance therapy for untreated advanced-stage FL. The complete response rate at the end of induction was higher with R-B and relapses were more frequent with R-CHOP. During induction, cytopenias were significantly more frequent with R-CHOP and so was the use of colony-stimulating factors. During maintenance therapy, R-B showed more neutropenia and infectious toxicity. After a median follow-up of 81 months (95% CI: 77-86), the 6-year rates of progression-free survival (PFS) were 79% (95% CI: 72-86) for R-bendamustine vs. 67% (95% CI: 61-73) for R-CHOP (p = 0. 046), and 6-year overall survival (OS) values were 91% (95% CI: 86-96) for R-B vs. 91% (95% CI: 87-94) for R-CHOP (p = 0. 49). In conclusion, R-B followed by rituximab maintenance therapy in patients with previously untreated FL resulted in significantly longer PFS than R-CHOP, with older patients also benefiting from this treatment without further toxicity. Adverse events during maintenance were more frequent with R-B without impacting mortality.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Cancers, Vol. 16 Núm. 7 (april 2024) , p. 1285, ISSN 2072-6694

DOI: 10.3390/cancers16071285
PMID: 38610963

12 p, 472.8 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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