Global mortality and readmission rates following COPD exacerbation-related hospitalisation : a meta-analysis of 65 945 individual patients
Waeijen-Smit, Kiki (Maastricht University Medical Center)
Crutsen, Mieke (Pulmonary Function and Exercise Testing Laboratory (Maastricht, Països Baixos))
Keene, Spencer (University of Birmingham)
Miravitlles, Marc (Vall d'Hebron Institut de Recerca (VHIR))
Crisafulli, Ernesto (Department of Medicine. University of Verona)
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
Mueller, Christian (University Hospital Basel (Basilea, Suïssa))
Schuetz, Philip (University of Basel)
Ringbæk, Thomas J. (Copenhagen University Hospital-Hvidovre)
Fabbian, Fabio (University of Ferrara)
Mekov, Evgeni (Medical University Sofia)
Harries, Timothy H. (King's College London)
Lun, Chung-Tat (Alice Ho Miu Ling Nethersole Hospital (Hong Kong))
Ergan, Begum (Dokuz Eylul University (Izmir, Turquia))
Esteban, Cristóbal (Hospital Galdakao)
Quintana Lopez, José M. (Hospital de Galdakao (Usansolo, Biscaia))
López Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Chang, Catherina L. (Waikato Hospital (Hamilton, Nova Zelanda))
Hancox, Robert J. (University of Otago)
Shafuddin, Eskandarain (Waikato Hospital (Hamilton, Nova Zelanda))
Ellis, Hollie (Waikato Hospital (Hamilton, Nova Zelanda))
Janson, Christer (Uppsala University)
Ulrik, Charlotte Suppli (Copenhagen University Hospital-Hvidovre)
Gudmundsson, Gunnar (University of Iceland School of Health Sciences)
Epstein, Danny (Rambam Health Care Center (Haifa, Israel))
Dominguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Osadnik, Christian (Monash University)
Alia, Inmaculada (Hospital Universitario de Getafe (Madrid))
Spannella, Francesco (University Politecnica delle Marche)
Karakurt, Zuhal (University of Health Sciences Istanbul Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital)
Mehravaran, Hossein (Mazandaran University of Medical Sciences (Sari, Iran))
Utens, Cecile (Libra Rehabilitation and Audiology (Eindhoven, Holanda))
de Kruif, Martijn D. (Zuyderland Medical Center (Heerlen, Països Baixos))
San Ko, Fanny Wai (The Chinese University of Hong Kong)
Trethewey, Samuel P. (University of Exeter (Regne Unit))
Turner, Alice M. (Birmingham Women's and Children's Hospital (Regne Unit))
Bumbacea, Dragos (Elias Emergency University Hospital (Bucharest, Romania))
Murphy, Patrick B. (King's College London)
Vermeersch, Kristina (Katholieke Universiteit te Leuven (1970-))
Zilberman-Itskovich, Shani (Tel Aviv University)
Steer, John (North Tyneside General Hospital (Regne Unit))
Echevarria, Carlos (Royal Victoria Infirmary)
Bourke, Stephen C. (North Tyneside General Hospital (Regne Unit))
Lane, Nicholas (Royal Victoria Infirmary)
De Batlle, Jordi (Institut de Recerca Biomèdica de Lleida)
Sprooten, Roy T.M. (Maastricht University Medical Center)
Russell, Richard (King's College London)
Faverio, Paola (Università degli Studi di Milano-Bicocca)
Cross, Jane L. (University of East Anglia (Norwich, Regne Unit))
Prins, Hendrik J. (Catharina Hospital Eindhoven (Eindhoven, Països Baixos))
Spruit, Martijn A. (Maastricht University Medical Center)
Simons, Sami O. (Maastricht University Medical Center)
Houben-Wilke, Sarah (Maastricht University Medical Center)
Franssen, Frits M. E. (Maastricht University Medical Center)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6. 2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1. 8%, 5. 5% and 10. 9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7. 1%, 12. 6% and 32. 1%, respectively, with noticeable variability between studies and countries. Strongest predictors of mortality and hospital readmission included noninvasive mechanical ventilation and a history of two or more ECOPD-related hospitalisations.
Nota:	The current study was co-funded by the PPP Allowance made available by Health∼Holland, Top Sector Life Sciences & Health (LSHI19003) and ZonMWAQ10 (ERACoSysMed grant #90030355). Funding information for this article has been deposited with the Crossref Funder Registry.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	ERJ Open Research, Vol. 10 Núm. 1 (2024) , p. 838-2023, ISSN 2312-0541

DOI: 10.1183/23120541.00838-2023
PMID: 38410700

20 p, 2.1 MB

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