Real-World Evidence of Relapsed/Refractory Mantle Cell Lymphoma Patients and Treatments : A Systematic Review
Sancho, Juan Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sorigue, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rubio-Azpeitia, Eva (Janssen-Cilag)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2024
Resum:	Introduction: Mantle cell lymphoma (MCL) is an incurable disease with an aggressive clinical course, and most patients eventually relapse after chemotherapy. Targeted therapies developed for relapsed/refractory MCL have been approved based on clinical trial data. However, real-world setting data are scarce and scattered. Areas Covered: This systematic review aimed to collect, synthesize, and describe the characteristics and treatment outcomes of patients with relapsed/refractory MCL after receiving a second or subsequent line of therapy in the real-world setting. Expert Opinion: R/R MCL is clinically and biologically heterogeneous and still represents a therapeutic challenge, with high-risk and early relapsed patients remaining an unmet medical need. This systematic review is limited by the quality of the available data and the difficulty of comparing outcomes in R/R MCL due to the heterogeneity of the disease, but the results suggest that covalent BTKis should be positioned as second-line therapy, followed by CAR T-cells in BTK-i-relapsed patients. Chemo-free and combination therapies with established chemoimmunotherapy backbones in the relapsed and front-line settings have been recently developed, and front-line options are being improved to move targeted and cellular therapies to earlier lines, including front-line therapy, in elderly and younger fit patients. In the upcoming years, many new targeted agents will play an important role and will be incorporated to the routine practice as their sequence, and outcomes in unselected patients are determined.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	CAR-T cells ; Ibrutinib ; Mantle cell lymphoma ; Real-world evidence ; Relapsed/refractory mantle cell lymphoma (R/RMCL) ; Treatment efficacy
Publicat a:	Journal of Blood Medicine, Vol. 15 (may 2024) , p. 239-254, ISSN 1179-2736

DOI: 10.2147/JBM.S463946
PMID: 38812568

16 p, 686.3 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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