CBT4CBT web-based add-on treatment for cocaine use disorder : Study protocol for a randomized controlled trial
Mallorquí-Bagué, Núria (Institut d'Investigació Biomèdica Sant Pau)
Palazón-Llecha, A. (Universitat de Girona)
Madre Rull, Mercè (Institut d'Investigació Biomèdica Sant Pau)
Batlle, Francesca (Institut d'Investigació Biomèdica Sant Pau)
Duran-Sindreu, Santiago (Institut d'Investigació Biomèdica Sant Pau)
Trujols, Joan (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Cocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i. e. , CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences. All individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48-72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment). To the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe. Trial registration: IIBSP-CTB-2020-116, NCT05207228. Submitted 8 of April 2021, posted 26 of January 2022. https://clinicaltrials. gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder&draw=2&rank=1.
Ajuts:	Instituto de Salud Carlos III PI20/00929
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Clinical trial ; Cocaine use disorder ; Cognitive behavioral therapy ; Gender ; Predictive factors ; Protocol ; Treatment ; Treatment outcome
Publicat a:	Frontiers in psychiatry, Vol. 14 (2023) , p. 1051528, ISSN 1664-0640

DOI: 10.3389/fpsyt.2023.1051528
PMID: 36937712

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