Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease
Santos García, Diego (Complejo Hospitalario Universitario de A Coruña)
Laguna, Ariadna (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Hernández-Vara, Jorge (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol)
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña)
Feal Painceiras, Maria J. (Complejo Hospitalario Universitario de A Coruña)
Íñiguez Alvarado, María Cristina (Complejo Hospitalario Universitario de A Coruña)
García Díaz, Iago (Complejo Hospitalario Universitario de A Coruña)
Jesús, Silvia (Universidad de Sevilla)
Boungiorno, Maria Teresa (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Planellas, Lluís (Clínica del Pilar)
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona)
García Caldentey, Juan (Centro Neurológico Oms 42)
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi)
Legarda, Ines (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra)
López Manzanares, Lydia (Hospital Universitario de la Princesa (Madrid))
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Ávila Rivera, Maria A. (Consorci Sanitari Integral. Hospital General de L'Hospitalet)
Gómez Mayordomo, Víctor (Hospital Universitario Clínico San Carlos (Madrid))
Nogueira, Víctor (Hospital Da Costa Burela)
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya))
Dotor García-Soto, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Borrué, Carmen (Hospital Universitario Infanta Sofía)
Solano Vila, Berta (Institut Català de la Salut)
Álvarez Sauco, María (Hospital General Universitario de Elche)
Vela, Lydia (Hospital Universitario Fundación Alcorcón)
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta)
Cubo, Esther (Complejo Asistencial Universitario de Burgos)
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna))
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Alonso Losada, Maria G. (Hospital Álvaro Cunqueiro (Vigo))
López Ariztegui, Nuria (Complejo Hospitalario de Toledo)
Gastón, Itziar (Complejo Hospitalario de Navarra)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Mendez-Gonzalez, Manuel (Hospital Universitario Central de Asturias)
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra)
Rúiz Martínez, Javier (Hospital de Donostia (Sant Sebastià, País Basc))
Valero, Caridad (Hospital Arnau de Vilanova (València))
Kurtis, Mónica (Hospital Ruber Internacional)
González Ardura, Jessica (Hospital Universitario de Cabueñes (Gijón))
Alonso Redondo, Ruben (Universitario Lucus Augusti (HULA))
Ordás Bandera, Carlos Manuel (Hospital Universitario Rey Juan Carlos (Madrid))
López Díaz, Luis M. (Hospital Álvaro Cunqueiro (Vigo))
McAfee, Darrian (University of Maryland School of Medicine)
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Mir, Pablo (Universidad de Sevilla)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. At baseline, data from 681 PD patients (mean age 62. 54 ± 8. 93) fit the criteria for analysis. Of them, 410 (60. 2%) were males and 271 (39. 8%) females. There were no differences between the groups in mean age (62. 36 ± 8. 73 vs. 62. 8 ± 9. 24; p = 0. 297) or in the time from symptoms onset (5. 66 ± 4. 65 vs. 5. 21 ± 4. 11; p = 0. 259). Symptoms such as depression (p < 0. 0001), fatigue (p < 0. 0001), and pain (p < 0. 00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0. 0001), speech problems (p < 0. 0001), rigidity (p < 0. 0001), and hypersexuality (p < 0. 0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0. 002). Perception of quality of life was generally worse in females (PDQ-39, p = 0. 002; EUROHIS-QOL8, p = 0. 009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0. 012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0. 001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.
Ajuts:	Ministerio de Economía y Competitividad PI16/01575
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gender ; Motor ; Non-motor symptoms ; Parkinson's disease ; Quality of life ; Sex
Publicat a:	Journal of clinical medicine, Vol. 12 Núm. 4 (february 2023) , p. 1329, ISSN 2077-0383

DOI: 10.3390/jcm12041329
PMID: 36835866

16 p, 921.9 KB

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