Saturated fat and human health : a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines
Johnston, Bradley C. (School of Public Health (Toronto, Canadà))
Zeraatkar, Dena (McMaster University (Canadà))
Steen, Jeremy P. (McMaster University (Canadà))
de Jauregui, Diego Rada Fernandez (Texas A&M University (Estats Units d'Amèrica))
Zhu, Hongfei (Lanzhou University (Xina))
Sun, Mingyao (Lanzhou University (Xina))
Cooper, Matthew (University of Alberta (Canadà))
Maraj, Małgorzata (Jagiellonian University Medical College (Polònia))
Prokop-Dorner, Anna (Jagiellonian University Medical College (Polònia))
Reyes, Boris Castro (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Valli, Claudia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Storman, Dawid (Uniwersytet Jagielloński (Polònia))
Karam, Giorgio (University of Manitoba (Canadà))
Zajac, Joanna (Jagiellonian University Medical College (Polònia))
Ge, Long (Lanzhou University (Xina))
Swierz, Mateusz Jan (Jagiellonian University Medical College (Polònia))
Ghosh, Nirjhar R. (Texas A&M University (Estats Units d'Amèrica))
Vernooij, Robin W. M. (University Medical Center Utrecht (Països Baixos))
Chang, Yaping (McMaster University (Canadà))
Zhao, Yunli (Sichuan University (Xina))
Thabane, Lehana (McMaster University (Canadà))
Guyatt, Gordon (Faculty of Health Sciences (Canadà))
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Hooper, Lee (University of East Anglia (Regne Unit))
Bala, Malgorzata M. (Jagiellonian University Medical College (Polònia))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	The health effects of dietary fats are a controversial issue on which experts and authoritative organizations have often disagreed. Care providers, guideline developers, policy-makers, and researchers use systematic reviews to advise patients and members of the public on optimal dietary habits, and to formulate public health recommendations and policies. Existing reviews, however, have serious limitations that impede optimal dietary fat recommendations, such as a lack of focus on outcomes important to people, substantial risk of bias (RoB) issues, ignoring absolute estimates of effects together with comprehensive assessments of the certainty of the estimates for all outcomes. We therefore propose a methodologically innovative systematic review using direct and indirect evidence on diet and food-based fats (i. e. , reduction or replacement of saturated fat with monounsaturated or polyunsaturated fat, or carbohydrates or protein) and the risk of important health outcomes. We will collaborate with an experienced research librarian to search MEDLINE, EMBASE, CINAHL, and the Cochrane Database of Systematic Reviews (CDSR) for randomized clinical trials (RCTs) addressing saturated fat and our health outcomes of interest. In duplicate, we will screen, extract results from primary studies, assess their RoB, conduct de novo meta-analyses and/or network meta-analysis, assess the impact of missing outcome data on meta-analyses, present absolute effect estimates, and assess the certainty of evidence for each outcome using the GRADE contextualized approach. Our work will inform recommendations on saturated fat based on international standards for reporting systematic reviews and guidelines. Our systematic review and meta-analysis will provide the most comprehensive and rigorous summary of the evidence addressing the relationship between saturated fat modification for people-important health outcomes. The evidence from this review will be used to inform public health nutrition guidelines. PROSPERO Registration: CRD42023387377.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Diet ; Dietary Fats ; Humans ; Meta-Analysis as Topic ; Public Health ; Systematic Reviews as Topic
Publicat a:	Systematic Reviews, Vol. 12 Núm. 1 (december 2023) , p. 39, ISSN 2046-4053

DOI: 10.1186/s13643-023-02209-1
PMID: 36918997

8 p, 1.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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