A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW) : A study protocol
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Carrasco-Labra, Alonso (Universidad de Chile (Xile))
Brignardello-Petersen, Romina (Universidad de Chile (Xile))
Neumann, Ignacio (Pontificia Universidad Católica de Chile)
Akl, Elie A. (State University of New York (Estats Units d'Amèrica))
Sun, Xin (Sichuan University (Xina))
Johnston, Bradley C. (The Hospital for Sick Children Research Institute)
Briel, Matthias (University Hospital Basel (Basilea, Suïssa))
Busse, Jason (McMaster University (Canadà))
Glujovsky, Demian (Argentine Cochrane Centre IECS (Buenos Aires))
Granados, Carlos E. (Universidad de La Sabana)
Iorio, Alfonso (McMaster University (Canadà))
Irfan, Affan B. (University of Illinois (Estats Units d'Amèrica))
Martínez García, Laura (Institut d'Investigació Biomèdica Sant Pau)
Mustafa, Reem (University Of Missouri-Kansas City (Estats Units d'Amèrica))
Ramirez-Morera, Anggie (IHCAI Foundation and Central America Cochrane)
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau)
Tikkinen, Kari A. O. (University of Helsinki (Finlàndia))
Ebrahim, Shanil (University of Toronto (Canadà))
Vandvik, Per Olav (Norwegian Knowledge Centre for the Health Services (Noruega))
Zhang, Yuqing (McMaster University (Canadà))
Selva, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sanabria, Andrea Juliana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Zazueta, Oscar E. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vernooij, Robin W. M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Schünemann, Holger J. (McMaster University (Canadà))
Guyatt, Gordon (McMaster University (Canadà))
Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Data:	2013
Resum:	Background: Clinicians, providers and guideline panels use absolute effects to weigh the advantages and downsides of treatment alternatives. Relative measures have the potential to mislead readers. However, little is known about the reporting of absolute measures in systematic reviews. The objectives of our study are to determine the proportion of systematic reviews that report absolute measures of effect for the most important outcomes, and ascertain how they are analyzed, reported and interpreted. Methods/design: We will conduct a methodological survey of systematic reviews published in 2010. We will conduct a 1:1 stratified random sampling of Cochrane vs. non-Cochrane systematic reviews. We will calculate the proportion of systematic reviews reporting at least one absolute estimate of effect for the most patient-important outcome for the comparison of interest. We will conduct multivariable logistic regression analyses with the reporting of an absolute estimate of effect as the dependent variable and pre-specified study characteristics as the independent variables. For systematic reviews reporting an absolute estimate of effect, we will document the methods used for the analysis, reporting and interpretation of the absolute estimate. Discussion: Our methodological survey will inform current practices regarding reporting of absolute estimates in systematic reviews. Our findings may influence recommendations on reporting, conduct and interpretation of absolute estimates. Our results are likely to be of interest to systematic review authors, funding agencies, clinicians, guideline developers and journal editors.
Ajuts:	Ministerio de Ciencia e Innovación CP09/00137 Ministerio de Economía y Competitividad CM12/00168
Nota:	7. Source of funding (partially or completely funded by private for-profit organization or authors with finan-cial conflicts of interest vs. others).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Absolute effect measures ; Data reporting ; Evidence-based medicine ; Meta-analysis ; Numbers needed to treat ; Statistical data ; Systematic reviews
Publicat a:	Systematic Reviews, Vol. 2 Núm. 1 (13 2013) , p. 113, ISSN 2046-4053

DOI: 10.1186/2046-4053-2-113
PMID: 24330779

8 p, 222.8 KB

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