Incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infection in European hospitals : the COMBACTE-NET ARTHR-IS multi-centre study
Espíndola, Reinaldo (Instituto de Biomedicina de Sevilla)
Vella, Venanzio (GlaxoSmithKline (Itàlia))
Benito, Natividad (Institut d'Investigació Biomèdica Sant Pau)
Mur, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Tedeschi, Sara (IRCCS Azienda Ospedaliero Universitaria di Bologna (Itàlia))
Zamparini, Eleonora (University of Bologna (Itàlia))
Hendriks, Johannes G. E. (Máxima MC (Països Baixos))
Sorlí, Luisa (Universitat Pompeu Fabra)
Murillo Rubio, Oscar (Hospital Universitari de Bellvitge)
Soldevila-Boixader, Laura (Hospital Universitari de Bellvitge)
Scarborough, Mathew (Oxford University Hospitals NHS Foundation Trust (Regne Unit))
Scarborough, Claire (Oxford University Hospitals NHS Foundation Trust (Regne Unit))
Kluytmans, Jan A. J. W. (Utrecht University (Països Baixos))
Ferrari, Matteo Carlo (Humanitas Research Hospital (Ìtàlia))
Pletz, Mathias (Jena University Hospital (Alemanya))
McNamara, Iain R. (Norfolk and Norwich University Hospital (Regne Unit))
Escudero-Sanchez, Rosa (Hospital Universitario Ramón y Cajal (Madrid))
Arvieux, Cédric (Centre Hospitalier Universitaire de Rennes (França))
Batailler, Cécile (Croix Rousse Hospital (França))
Dauchy, Frédéric Antoine (Centre Hospitalier Universitaire de Bordeaux (França))
Liu, Waiyan (Catharina Hospital Eindhoven (Eindhoven, Països Baixos))
Lora-Tamayo, Jaime (Hospital 12 de Octubre (Madrid))
Praena-Segovia, Julia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ustianowski, Andrew P. (North Manchester General Hospital (Regne Unit))
Cinconze, Elisa (GlaxoSmithKline (Itàlia))
Pellegrini, Michele (GlaxoSmithKline (Itàlia))
Bagnoli, Fabio (GlaxoSmithKline (Itàlia))
Rodríguez-Baño, Jesús (Universidad de Sevilla (Sevilla, Andalusia))
Del-Toro-López, Maria Dolores (Universidad de Sevilla (Sevilla, Andalusia))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	The aim of this study was to estimate the incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infections (SA-PJI) after primary hip and knee arthroplasty in European centres. This study was conducted in patients who underwent primary hip and knee arthroplasty in 19 European hospitals between 2014 and 2016. The global incidence of PJI and SA-PJI was calculated. The associated disease burden was measured indirectly as infection-related mortality plus loss of function. For healthcare utilization, number and duration of hospitalizations, number and type of surgical procedures, duration of antibiotic treatments, and number of outpatient visits were collected. Subgroup and regression analyses were used to evaluate the impact of SA-PJI on healthcare utilization, controlling for confounding variables. The incidence of PJI caused by any micro-organism was 1. 41%, and 0. 40% for SA-PJI. Among SA-PJI, 20. 7% were due to MRSA with substantial regional differences, and were more frequent in partial hip arthroplasty (PHA). Related deaths and loss of function occurred in 7. 0% and 10. 2% of SA-PJI cases, respectively, and were higher in patients with PHA. Compared with patients without PJI, patients with SA-PJI had a mean of 1. 4 more readmissions, 25. 1 more days of hospitalization, underwent 1. 8 more surgical procedures, and had 5. 4 more outpatient visits, controlling for confounding variables. Healthcare utilization was higher in patients who failed surgical treatment of SA-PJI. This study confirmed that the SA-PJI burden is high, especially in PHA, and provided a solid basis for planning interventions to prevent SA-PJI.
Ajuts:	Ministerio de Economía y Competitividad RD16/0016/0001 Ministerio de Economía y Competitividad RD16/0016/0002 Ministerio de Economía y Competitividad RD16/0016/0005 Ministerio de Economía y Competitividad RD16/0016/0009 Ministerio de Economía y Competitividad RD16/0016/0011 Ministerio de Economía y Competitividad RD16/0016/0015
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Healthcare utilization ; Incidence ; Prosthetic joint infection ; Staphylococcus aureus ; Treatment failure
Publicat a:	The journal of hospital infection, Vol. 142 (december 2023) , p. 9-17, ISSN 1532-2939

DOI: 10.1016/j.jhin.2023.09.012
PMID: 37797656

9 p, 283.8 KB

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