Left and Right Ventricle Late Remodeling Following Myocardial Infarction in Rats
Stefanon, Ivanita (Federal University of Espirito Santo)
Valero-Muñoz, María (Universidad Complutense de Madrid)
Fernandes, Aurélia Araújo (Federal University of Espirito Santo)
Ribeiro, Rogério Faustino (Federal University of Espirito Santo)
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Miana, Maria (Universidad Complutense de Madrid)
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau)
Spalenza, Jessica S. (Federal University of Espirito Santo)
Lahera, Vicente (Universidad Complutense de Madrid)
Vassallo, Paula F. (Federal University of Espirito Santo)
Cachofeiro, Victoria (Universidad Complutense de Madrid)
Universitat Autònoma de Barcelona

Data:	2013
Resum:	Background:The mechanisms involved in cardiac remodeling in left (LV) and right ventricles (RV) after myocardial infarction (MI) are still unclear. We assayed factors involved in collagen turnover in both ventricles following MI in rats either presenting signs of heart failure (pulmonary congestion and increased LVEDP) or not (INF-HF or INF, respectively). Methods:MI was induced in male rats by ligation of the left coronary artery. Four weeks after MI gene expression of collagen I, connective tissue growth factor (CTGF), transforming growth factor β (TGF-β) and lysyl oxidase (LOX), metalloproteinase-2 (MMP2) and tissue inhibitor metalloproteinase-2 (TIMP2) as well as cardiac hemodynamic in both ventricles were evaluated. Results:Ventricular dilatation, hypertrophy and an increase in interstitial fibrosis and myocyte size were observed in the RV and LV from INF-HF animals, whereas only LV dilatation and fibrosis in RV was present in INF. The LV fibrosis in INF-HF was associated with higher mRNA of collagen I, CTGF, TGF-β and LOX expressions than in INF and SHAM animals, while MMP2/TIMP2 mRNA ratio did not change. RV fibrosis in INF and INF-HF groups was associated with an increase in LOX mRNA and a reduction in MMP2/TIMP2 ratio. CTGF mRNA was increased only in the INF-HF group. Conclusions:INF and INF-HF animals presented different patterns of remodeling in both ventricles. In the INF-HF group, fibrosis seems to be consequence of collagen production in LV, and by reductions in collagen degradation in RV of both INF and INF-HF animals. © 2013 Stefanon et al.
Ajuts:	Ministerio de Economía y Competitividad PI12/01952 Ministerio de Economía y Competitividad RD12/0042/0053
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 8 Núm. 5 (31 2013) , p. e64986, ISSN 1932-6203

DOI: 10.1371/journal.pone.0064986
PMID: 23741440

11 p, 2.9 MB

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