Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
Callejo, Justo (Universitat de Barcelona)
Salvador, Cistina (Universitat de Barcelona)
González-Nuñez, Santiago (Universitat de Barcelona)
Almeida, Laura (Universitat de Barcelona)
Rodríguez, Luciano (Institut d'Investigació Biomèdica Sant Pau)
Marqués, Laura (Clínica Sagrada Familia)
Valls, Ana (Hospital Sant Joan de Déu (Esplugues de Llobregat, Catalunya))
Lailla, José María (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Data:	2013
Resum:	Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic drugs or radiation. Numerous studies have confirmed that autograft of frozen-thawed ovarian tissue can restore ovarian function and fertility. A total of twenty-two live births have been reported but we still have to consider this technique as experimental. The main problem is that the implant undergoes ischemia until neoangiogenesis is restored, resulting in significant follicular loss. At the moment, there are numerous publications in different medical fields that publish successful experiences with plasma rich in platelets (PRP) in different clinical situations promoting angiogenesis. Thus, we considered the possibility of using it in the field of ovarian autologous transplantation in order to improve the vascularization of the implant and its quality. For this, both thawed ovarian tissue as practiced pockets on the rear side of the broad ligament which have been placed, have been impregnated with PRP. We can say that the implant treated in this way has had a rapid and successful response. We report a special interesting case because this is the first time that this technique is performed successfully in a woman without ovaries combined with growth factors to promote neoangiogenesis. Obviously, the results of the hormonal response come exclusively from the implanted tissue in these special conditions. © 2013 Callejo et al. ; licensee BioMed Central Ltd.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	AMH ; Antimüllerian hormone ; Cryopreservation ; Fertility preservation ; Ovarian tissue transplantation ; Platelet rich plasma ; PRP
Publicat a:	Journal of Ovarian Research, Vol. 6 Núm. 1 (2013) , p. 33, ISSN 1757-2215

DOI: 10.1186/1757-2215-6-33
PMID: 23647552

6 p, 1.1 MB

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