Impact of the LDL subfraction phenotype on Lp-PLA2 distribution, LDL modification and HDL composition in type 2 diabetes
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau)
Vinagre, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
De Juan-Franco, Elena (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sánchez-Hernández, Juan (Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas)
Bonet-Marques, Rosa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ordóñez, J. (Jordi), 1952- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau)

Data:	2013
Resum:	Background: Qualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes. The objective of this study was to assess the impact of low-density lipoprotein (LDL) subfraction phenotype on the qualitative characteristics of LDL and high-density lipoprotein (HDL) in patients with type 2 diabetes. Methods: One hundred twenty two patients with type 2 diabetes in poor glycemic control and 54 healthy subjects were included in the study. Patients were classified according to their LDL subfraction phenotype. Seventy-seven patients presented phenotype A whereas 45 had phenotype B. All control subjects showed phenotype A. Several forms of modified LDL, HDL composition and the activity and distribution of lipoprotein-associated phospholipase A2 (Lp-PLA2) were analyzed. Results: Oxidized LDL, glycated LDL and electronegative LDL were increased in both groups of patients compared with the control group. Patients with phenotype B had increased oxidized LDL and glycated LDL concentration than patients with phenotype A. HDL composition was abnormal in patients with diabetes, being these abnormalities more marked in patients with phenotype B. Total Lp-PLA2 activity was higher in phenotype B than in phenotype A or in control subjects. The distribution of Lp-PLA2 between HDL and apoB-containing lipoproteins differed in patients with phenotype A and phenotype B, with higher activity associated to apoB-containing lipoproteins in the latter. Conclusions: The presence of LDL subfraction phenotype B is associated with increased oxidized LDL, glycated LDL and Lp-PLA2 activity associated to apoB-containing lipoproteins, as well as with abnormal HDL composition. © 2013 Sánchez-Quesada et al. ; licensee BioMed Central Ltd.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1205
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	High-density lipoprotein ; LDL subfraction phenotype ; Lipoprotein-associated phospholipase A2 ; Low-density lipoprotein ; Modified LDL ; Type 2 diabetes
Publicat a:	Cardiovascular diabetology, Vol. 12 Núm. 1 (may 2013) , p. 112, ISSN 1475-2840

DOI: 10.1186/1475-2840-12-112
PMID: 23915379

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