Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts : The BODE and CHAIN Experience
De Torres, Juan Pablo (Instituto de Investigación Sanitaria de Navarra)
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Marín, José María (Hospital Universitario Miguel Servet (Saragossa))
Cabrera-Lopez, Carlos (Hospital Universitario de Gran Canaria Dr. Negrín)
Marín, Marta (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Ezponda, Ana (Clínica Universidad de Navarra)
Cosio, Borja G. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Martínez-González, Cristina (Instituto de Investigación Sanitaria del Principado de Asturias)
Solanes García, Ingrid (Institut de Recerca Sant Pau)
Fuster, Antonia (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Calle Rubio, Myriam (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Peces-Barba, German (Hospital Universitario Fundación Jiménez Díaz)
Gotera-Rivera, Carolina (Hospital Universitario Fundación Jiménez Díaz)
Feu-Collado, Nuria (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Marin, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alcaide, Ana Belén (Clínica Universidad de Navarra)
Sangro, Matilde (Clínica Universidad de Navarra)
Bastarrika, Gorka (Clínica Universidad de Navarra)
Celli, Bartolomé R. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))

Data:	2024
Resum:	Introduction: The Global Lung Function Initiative (GLI) has proposed new criteria for airflow limitation (AL) and recommends using these to interpret spirometry. The objective of this study was to explore the impact of the application of the AL GLI criteria in two well characterized GOLD-defined COPD cohorts. Methods: COPD patients from the BODE (n = 360) and the COPD History Assessment In SpaiN (CHAIN) cohorts (n = 722) were enrolled and followed. Age, gender, pack-years history, BMI, dyspnea, lung function measurements, exercise capacity, BODE index, history of exacerbations and survival were recorded. CT-detected comorbidities were registered in the BODE cohort. The proportion of subjects without AL by GLI criteria was determined in each cohort. The clinical, CT-detected comorbidity, and overall survival of these patients were evaluated. Results: In total, 18% of the BODE and 15% of the CHAIN cohort did not meet GLI AL criteria. In the BODE and CHAIN cohorts respectively, these patients had a high clinical burden (BODE ≥ 3: 9% and 20%; mMRC ≥ 2: 16% and 45%; exacerbations in the previous year: 31% and 9%; 6MWD < 350 m: 15% and 19%, respectively), and a similar prevalence of CT-diagnosed comorbidities compared with those with GLI AL. They also had a higher rate of long-term mortality - 33% and 22% respectively. Conclusions: An important proportion of patients from 2 GOLD-defined COPD cohorts did not meet GLI AL criteria at enrolment, although they had a significant burden of disease. Caution must be taken when applying the GLI AL criteria in clinical practice.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Airway obstruction ; Application ; COPD ; Clinical ; Global Lung Function Initiative ; Mortality
Publicat a:	Archivos de bronconeumologia, Vol. 60 Núm. 1 (january 2024) , p. 10-15, ISSN 1579-2129

DOI: 10.1016/j.arbres.2023.10.002
PMID: 37925245

6 p, 839.5 KB

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