| Data: |
2024 |
| Resum: |
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson's disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson's Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed to assess functional limitations caused by cognitive impairment, while reducing the influence of motor impairment. The aim of this multicenter study was to (i) validate the Italian version of the PD-CFRS in PD, (ii) determine optimal cut-off scores for detecting MCI and dementia in PD, (iii) compare its performances with the most established functional assessment tool (IADL). Six hundred and sixty nine PD participants were recruited from 4 Italian Movement Disorders centers (Venice, Milan, Gravedona, and Salerno). They underwent Level-II cognitive evaluation, which resulted in 282 PD-NC, 310 PD-MCI, and 77 PDD. The PD-CFRS's psychometric and clinimetric properties, applicability, and responsiveness were analyzed. The PD-CFRS showed high acceptability. Floor and ceiling effects were acceptable. It also displayed strong internal consistency (Cronbach's α = 0. 738), and test-retest reliability (ICC =. 854). The PD-CFRS demonstrated higher coefficient of variation to detect dysfunction in PD-MCI patients in comparison to the IADL scale (PD-CFRS 96% vs IADL 22. 5%). Convergent validity with the IADL was r = - 0. 638 and - 0. 527 in males and females, respectively. PD-CFRS total score negatively correlated with global cognition (MoCA corrected score r = - 0. 61; p < 0. 001). A cut-off score. |
| Ajuts: |
European Commission 825785
European Commission 101016902
|
| Nota: |
Altres ajuts: Prof. Angelo Antonini has received compensation for consultancy and speaker-related activities from UCB, Britannia, AbbVie, Zambon, Bial, Ever Pharma, Theravance Biopharma, Roche, General Electric, Medscape. He receives research support from Chiesi Pharmaceuticals, Lundbeck, Bial, Movement Disorders Society, Ministry of Education University and Research (MIUR) Grant ARS01_01081. The other authors declare that there are no additional disclosures to report. Open access funding provided by Università degli Studi di Padova. This paper was supported by the Ministry of Health under Grant Number GR-2016-02361986. |
| Drets: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: |
Anglès |
| Document: |
Article ; recerca ; Versió publicada |
| Matèria: |
PD-CFRS ;
Parkinson's disease ;
Parkinson's disease dementia ;
Parkinson's disease mild cognitive impairment |
| Publicat a: |
Journal of Neural Transmission, Vol. 131 Núm. 4 (april 2024) , p. 305-314, ISSN 1435-1463 |
visitant ::
identificació
(University of Padova)
