Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma : A Spanish multicenter study (PANMEKID)
Rojas-Holguín, Adela (Hospital Universitario de Badajoz)
Fondevila, Constantino (Hospital Universitario La Paz (Madrid))
Sanjuanbenito, Alfonso (Hospital Universitario Ramón y Cajal (Madrid))
Fabregat-Prous, Joan (Hospital Universitari de Bellvitge)
Secanella-Medayo, Luís (Hospital Universitari de Bellvitge)
Rotellar-Sastre, Fernando (Clínica Universidad de Navarra)
Pardo-Sánchez, Fernando (Clínica Universidad de Navarra)
Prieto-Calvo, Mikel (Hospital Universitario de Cruces (Barakaldo, País Basc))
Marín-Ortega, Héctor (Hospital Clínico San Carlos (Madrid))
Sánchez-Cabús, Santiago (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Diez-Valladares, Luis (Hospital Clínico San Carlos (Madrid))
Alonso-Casado, Óscar (MD Anderson Cancer Center (Madrid))
González-Serrano, Carmen (Hospital de Basurto (Bilbao, Biscaia))
Rodríguez-Sanjuan, Juan Carlos (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
García-Plaza, Gabriel (Hospital Universitario Insular de Gran Canaria)
Jaén-Torrejimeno, Isabel (Hospital Universitario de Badajoz)
Suárez-Muñoz, Miguel Ángel (Hospital Clinico Universitario Virgen de la Victoria (Màlaga))
Becerra-Massare, Antonio (Hospital Universitario Virgen de las Nieves (Granada))
Senra-del Rio, Paula (Hospital Álvaro Cunqueiro (Vigo))
Pando, Elizabeth (Hospital Universitari Vall d'Hebron)
López-Andújar, Rafael (Hospital Universitari i Politècnic La Fe (València))
Muñoz-Forner, Elena (Hospital Clínic Universitari (València))
Rodriguez-López, Mario (Hospital Clínico Universitario de Valladolid)
Pereira, Fernando (Hospital Universitario de Fuenlabrada ( Madrid))
Serrablo-Requejo, Alejandro (Hospital Universitario Miguel Servet (Saragossa))
Sánchez Turrión, Víctor (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Jiménez Garrido, Manuel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya))
Martín-Pérez, Elena (Hospital Universitario de la Princesa (Madrid))
Estevan-Estevan, Rafael (Fundació Institut Valencià d'Oncologia)
López-Guerra, Diego (Hospital Universitario de Badajoz)
Castell-Gómez, José (Hospital Universitario La Paz (Madrid))
Salinas-Gómez, Javier (Hospital Universitario La Paz (Madrid))
López-Baena, José Ángel (Hospital Gregorio Marañón (Madrid))
López-Ben, Santiago (Hospital Universitari de Girona Doctor Josep Trueta)
Solar-García, Lorena (Hospital Universitario Central de Asturias)
Pérez-Alonso, Alejandro J. (Complejo Hospitalario de Jaén)
Martínez-Insfran, Luis Alberto (Hospital Universitario San Juan de Alicante)
Blas, Juan Luis (Hospital Royo Villanova)
Cornejo, Marian (Hospital Marina Baixa (La Vila Joiosa, Alacant))
Gutierrez-Calvo, Alberto (Universidad de Extremadura)
Domingo-del Pozo, Carlos (Hospital Universitari Doctor Peset (València))
Ochando-Cerdan, Federico (Hospital Universitario Fundación Alcorcón)
Muñoz-Bellvis, Luis (Complejo Asistencial Universitario de Salamanca)
Rebollar-Saenz, José (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Sánchez, Belinda (Hospital Regional Universitario de Málaga)
Jover, José María (Hospital Universitario de Getafe (Madrid))
Gómez-Bravo, Miguel Ángel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ramia, José M. (Hospital General Universitario de Alicante (Alacant, País Valencià))
Blanco-Fernández, Gerardo (Hospital Universitario de Badajoz)

Data:	2024
Resum:	Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival. Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected. Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48. 9 months (95 % CI: 22. 2-56. 9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0. 179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0. 895). Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Iterative surgery ; Metastases ; Pancreatectomy ; Recurrence ; Renal cell carcinoma
Publicat a:	Surgical Oncology, Vol. 52 (february 2024) , p. 102039, ISSN 1879-3320

DOI: 10.1016/j.suronc.2024.102039
PMID: 38301449

8 p, 1.5 MB

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