Usefulness of Xpert MTB/RIF and Xpert Ultra to Categorize Risk of Tuberculosis Transmission to Household Contacts
Mol, Alexander (Hospital Universitari Vall d'Hebron)
Sánchez-Montalvá, Adrián (Universitat Autònoma de Barcelona. Departament de Medicina)
Espinosa-Pereiro, Juan (Universitat Autònoma de Barcelona. Departament de Medicina)
Aznar, Maria Luisa (Universitat Autònoma de Barcelona. Departament de Medicina)
Salvador Velez, Fernando Maria (Universitat Autònoma de Barcelona. Departament de Medicina)
Bosch-Nicolau, Pau (Universitat Autònoma de Barcelona. Departament de Medicina)
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron)
Jiménez, María Ángeles (Hospital Universitari Vall d'Hebron)
Rodrigo-Pendás, José Ángel (Hospital Universitari Vall d'Hebron)
Millet, Joan Pau (Institut de Recerca Sant Pau)
Saborit, Núria (Hospital Universitari Vall d'Hebron)
Broto, Claudia (Hospital Universitari Vall d'Hebron)
Molina Romero, Israel (Universitat Autònoma de Barcelona. Departament de Medicina)
Tórtola Fernández, María Teresa (Hospital Universitari Vall d'Hebron)

Data:	2024
Resum:	People with pulmonary tuberculosis (PTB) are contagious, particularly to their household contacts. Their infectivity has been associated with the bacterial load in sputum samples. This study investigated if the bacterial load in sputum samples as quantified by Xpert MTB/RIF and Xpert Ultra is correlated with the extent that latent tuberculosis infection (LTBI) occurred in household contacts of people with PTB. A retrospective study was performed including people with PTB presenting at Vall d'Hebron University Hospital, Barcelona, between 2011 and 2021. Their infection ratio, representing the proportion of household members found with LTBI in contact tracing investigation, was compared with the quantitative results of Xpert MTB/RIF and Xpert Ultra using ordinal regression analysis. A total of 107 people with PTB were included. Among their 398 household contacts, 126 (31. 7%) cases of LTBI and 14 cases with active TB disease (3. 5%) were reported. Higher bacterial load in Xpert MTB/RIF and Xpert Ultra baseline sputum was significantly associated with increased infection ratios, providing better estimates than conventional acid-fast bacilli (AFB) smear grading. Xpert MTB/RIF and Xpert Ultra could serve as an alternative to AFB sputum-smear grading in determining contact tracing priorities.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Contact investigation ; PCR ; Prevention ; Risk of transmission ; Tuberculosis
Publicat a:	Open Forum Infectious Diseases, Vol. 11 (august 2024) , ISSN 2328-8957

DOI: 10.1093/ofid/ofae450
PMID: 39165580

8 p, 544.6 KB

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