A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study
Peñuelas, Oscar (Hospital Universitario de Getafe (Madrid))
del Campo-Albendea, Laura (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Morales-Quinteros, Luis (Hospital Universitari Vall d'Hebron)
Muriel, Alfonso (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Nin, Nicolás (Hospital Español "Juan José Crottoggini")
Thille, Arnaud (University Hospital of Poitiers)
Du, Bin (Peking Union Medical College Hospital)
Pinheiro, Bruno (Federal University of Juiz de Fora)
Ríos, Fernando (Hospital Nacional Alejandro Posadas)
Marín, María Carmen (Hospital Regional 1° de Octubre)
Maggiore, Salvatore (Università Degli Studi G. d'Annunzio Chieti E Pescara)
Raymondos, Konstantinos (Hannover Medical School)
González, Marco (Universidad Pontificia Bolivariana (Colòmbia))
Bersten, Andrew (Flinders University (Austràlia))
Amin, Pravin (Bombay Hospital Institute of Medical Sciences)
Cakar, Nahit (Koç University (Turquia))
Suh, Gee Young (Center for Clinical Epidemiology of Samsung Medical Center (Corea del Sud))
Abroug, Fekri (Hospital Fattouma Bourguina (Tunísia))
Jibaja, Manuel (Hospital de Especialidades Eugenio Espejo (Equador))
Matamis, Dimitros (Papageorgiou Hospital (Grècia))
Zeggwagh, Amine Ali (Mohammed V University (Marroc))
Sutherasan, Yuda (Mahidol University (Tailàndia))
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Anzueto, Antonio (University of Texas Health)
Esteban, Andrés (Hospital Universitario de Getafe (Madrid))
Frutos-Vivar, Fernando (Hospital Universitario de Getafe (Madrid))
Del Sorbo, Lorenzo (University Health Network (Canadà))

Data:	2024
Resum:	Background: The trend over time and across different geographical areas of outcomes and management with noninvasive ventilation or invasive mechanical ventilation in patients admitted for acute exacerbations of chronic obstructive pulmonary disease and treated with ventilatory support is unknown. The purpose of this study was to describe outcomes and identify variables associated with survival for patients admitted to an intensive care unit (ICU) with acute exacerbation of chronic obstructive pulmonary disease [aeCOPD] who received noninvasive or invasive mechanical ventilation worldwide. Methods: Retrospective, multi-national, and multicenter studies, including four observational cohort studies, were carried out in 1998, 2004, 2010, and 2016 for the VENTILAGROUP following the same methodology. Results: A total of 1,848 patients from 1,253 ICUs in 38 countries admitted for aeCOPD and need of ventilatory support were identified in the four study cohorts and included in the study. The overall incidence of aeCOPD as a cause for ventilatory support at ICU admission significantly decreased over time and varied widely according to the gross national income. The mortality of patients admitted to ICU for aeCOPD and ventilatory support significantly decreased over time regardless of the geographical area and gross national income; however, there is a remarkable variability in ICU mortality according to geographical area and gross national income. The use of NPPV as the first attempt at ventilatory support has significantly increased over time, with a parallel reduction of invasive mechanical ventilation regardless of gross national income. Conclusion: In this worldwide observational study, including four sequential cohorts of patients over 18 years from 1998 to 2016, the mortality of patients admitted to ICU for aeCOPD and ventilatory support significantly decreased regardless of the geographical area and gross national income. Future research will need to investigate the reason for the remarkable variability in ICU mortality according to the geographical area, gross national income, and methods to select patients for the appropriate ventilatory support.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic obstructive pulmonary disease ; Exacerbation ; Mechanical ventilation ; Mortality
Publicat a:	Respiratory Research, Vol. 25 Núm. 1 (december 2024) , p. 434, ISSN 1465-993X

DOI: 10.1186/s12931-024-03037-0
PMID: 39696494

16 p, 1.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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