Prevalence of potentially inappropriate medications and prescription dynamics in elderly hospitalized patients in Spain
Puig Reixach, Maria Teresa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Leache, Leire (Instituto de Investigación Sanitaria de Navarra)
González-Senac, Nicolás M. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Carreras, Elisabeth (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Gutiérrez-Valencia, Marta (Instituto de Investigación Sanitaria de Navarra)
Losa López, Laura (Complex Hospitalari Universitari Moisès Broggi (Sant Joan Despí, Barcelona))
Revuelta-Herrero, José Luis (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Marrero-Álvarez, Patricia (Hospital Universitari Vall d'Hebron)
de Miguel Gascón, Monike (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Aguirrezabal Arredondo, A. (Hospital Universitario de Basurto (Bilbao, Biscaia))
Aranguren Redondo, María Asunción (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Vilariño, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ruiz Fernández, Verónica E. (Consorci Sanitari de Terrassa)
Fernández González, María Isabel (Hospital de Zumárraga (Guipúscoa, País Basc)))
Bilbao Aguirregomezcorta, Jaione (Hospital San Eloy (País Basc))
González-Guerrero, Celia (Hospital Sant Rafael (Barcelona))
del Pino Gaya, Beatriz (Parc sanitari Sant Joan de Déu (Barcelona, Catalunya))
Garin, Noé (Universitat Ramon Llull)

Data:	2024
Resum:	In recent years, the need for a more appropriate prescription of medications in the older population has emerged as a significant public health concern. In this study, we aimed to evaluate the prevalence of potentially inappropriate medications (PIM) in hospitalized adults aged ≥ 75. This was a retrospective descriptive observational study of patients at 16 hospitals in Spain. The study population included inpatients aged ≥ 75 admitted during a 7-day period (May 10 to 16, 2021). Data were obtained from the pharmacy databases of the participating hospitals. The list of PIMs was based on the Beers, STOPP-START, EU-PIM and PRISCUS criteria. A total of 4,183 patients were included. PIMs were detected in 23. 5% (N = 1,126) of the cohort. The prevalence rates at the participating hospitals ranged from 10% to 42. 5%. The PIM/patient ratio was 1. 2. The most common PIMs were midazolam, dexketoprofen, diazepam, and doxazosin, all of which (except for doxazosin) were more common in women. Benzodiazepines accounted for 70% of all PIMs. In 35% of cases, the PIMs were initiated before hospital admission. Of the 818 PIMs initiated during hospitalization, the two most common were benzodiazepines (49%) and anti-inflammatory drugs (25%). At discharge, only 4. 9% of the PIMs initiated during the hospital stay were still prescribed. In this population of older hospitalized patients, the overall prevalence of PIMs was moderate. However, the prevalence rate at the participating hospitals was highly variable. In most cases, PIMs prescribed prior to hospitalization for chronic conditions were not withdrawn during the hospital stay. No significant increase in PIMs was observed from pre-admission to post-discharge. These findings underscore the need for multidisciplinary interventions to optimize the pharmaceutical treatment in older adults in the hospital setting to reduce the consequences of PIMs in patients. The online version contains supplementary material available at 10. 1186/s12877-024-05308-3.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Inappropriate prescribing ; Aged ; Inpatients ; Patient discharge
Publicat a:	BMC geriatrics, Vol. 24 (september 2024) , ISSN 1471-2318

DOI: 10.1186/s12877-024-05308-3
PMID: 39350081

10 p, 1.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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