INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community
Meehan, Terrence F. (European Molecular Biology Laboratory)
Chen, Chao Kung (European Molecular Biology Laboratory)
Koscielny, Gautier (European Molecular Biology Laboratory)
Relac, Mike (European Molecular Biology Laboratory)
Wilkinson, Phil (European Molecular Biology Laboratory)
Flicek, Paul (European Molecular Biology Laboratory)
Parkinson, Helen (European Molecular Biology Laboratory)
Castro, Ana (Helmholtz Zentrum München)
Fessele, Sabine (Helmholtz Zentrum München)
Steinkamp, Ralph (Helmholtz Zentrum München)
Hagn, Michael (Helmholtz Zentrum München)
Raess, Michael (Helmholtz Zentrum München)
De Angelis, Martin Hrabé (Helmholtz Zentrum München)
Bottomley, Joanna (Wellcome Trust Sanger Institute (Regne Unit))
Ramirez-Solis, Ramiro (Wellcome Trust Sanger Institute (Regne Unit))
Smedley, Damian (Wellcome Trust Sanger Institute (Regne Unit))
Ball, Simon (Medical Research Council Harwell)
Blake, Andrew (Medical Research Council Harwell)
Fray, Martin (Medical Research Council Harwell)
Kenyon, Janet (Medical Research Council Harwell)
Mallon, Ann Marie (Medical Research Council Harwell)
Brown, Steve (Medical Research Council Harwell)
Massimi, Marzia (Consiglio Nazionale delle Ricerche)
Matteoni, Raffaele (Consiglio Nazionale delle Ricerche)
Tocchini-Valentini, Glauco (Consiglio Nazionale delle Ricerche)
Herault, Yann (Institut Clinique de la Souris)
Kollias, George (Biomedical Sciences Research Center Alexander Fleming)
Ulfhake, Brun (Karolinska Institutet (Estocolm, Suècia))
Demengeot, Jocelyne (Instituto Gulbenkian de Ciência)
Fremond, Cecile (Centre National de la Recherche Scientifique-TAAM)
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Montoliu, Lluis (Centro Nacional de Biotecnologia)
Soininen, Raija (University of Oulu)
Schughart, Klaus (Helmholtz Zentrum für Umweltforschung)
Brakebusch, Cord (University of Copenhagen)
Sedlacek, Radislav (Czech Centre for Phenogenomics)
Rülicke, Thomas (Institute of Laboratory Animal Science and Biomodels Austria)
McKerlie, Colin (Toronto Centre for Phenogenomics Inc)
Malissen, Bernard (Centre d'Immunophenomique, IN-SERM)
Iraqi, Fuad (Tel Aviv University)
Jonkers, Jos (The Netherlands Cancer Institute (Amsterdam, Països Baixos))
Russig, Holger (TSE Systems)
Huylebroeck, Danny (Stem Cell Institute)

Data:	2015
Resum:	The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www. infrafrontier. eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.
Ajuts:	European Commission 312325
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Nucleic acids research, Vol. 43, Núm. D1 (2015) , p. D1171-D1175, ISSN 1362-4962

DOI: 10.1093/nar/gku1193
PMID: 25414328

5 p, 1.2 MB

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