Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
Aranha, Mateus (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Montal, Victor (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
van den Brink, Hilde (University Medical Center Utrecht)
Pegueroles, Jordi (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Carmona Iragui, Maria (Institut de Recerca Sant Pau)
Videla Toro, Laura (Institut de Recerca Sant Pau)
Maure Blesa, Lucia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Benejam, Bessy (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Arranz Martínez, Javier (Institut de Recerca Sant Pau)
Valldeneu, Silvia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Barroeta, Isabel (Institut de Recerca Sant Pau)
Fernández, Susana (Institut de Recerca Sant Pau)
Ribas, Laia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Alcolea, Daniel (Institut de Recerca Sant Pau)
González-Ortiz, Sofía (Hospital Clínic i Provincial de Barcelona)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Biessels, Geert Jan (University Medical Center Utrecht)
Blesa, Rafael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Lleó, Alberto (Institut de Recerca Sant Pau)
Coutinho, Artur Martins (Universidade de São Paulo)
Leite, Cláudia Costa (Universidade de São Paulo)
Bejanin, Alexandre (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Fortea, Juan (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS. We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS. CMI prevalence was 11. 8% in DS, 4. 7% in controls, and 17. 5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype. This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11. 8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.
Ajuts:	Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI20/01330 Instituto de Salud Carlos III PI22/00307
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Down syndrome ; Cerebral amyloid angiopathy ; Cerebral microbleeds ; Cortical microinfarcts ; Magnetic resonance imaging ; Neuroimaging ; Small vessel diseases
Publicat a:	Alzheimer's & dementia, Vol. 20 Núm. 6 (june 2024) , p. 3906-3917, ISSN 1552-5279

DOI: 10.1002/alz.13797
PMID: 38644660

12 p, 748.6 KB

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