Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes : a systematic review
Felton, Jamie L. (Indiana University School of Medicine)
Redondo, Maria J. (Texas Children's Hospital)
Oram, Richard (Royal Devon University Healthcare NHS Foundation Trust)
Speake, Cate (Benaroya Research Institute)
Long, Sarah Alice (Benaroya Research Institute)
Onengut-Gumuscu, Suna (University of Virginia)
Rich, Stephen S. (University of Virginia)
Monaco, Gabriela S.F. (Indiana University School of Medicine)
Harris-Kawano, Arianna (Indiana University School of Medicine)
Perez, Dianna L. (Indiana University School of Medicine)
Saeed, Zeb (Indiana University School of Medicine)
Hoag, Benjamin (University of South Dakota School of Medicine. E Clark St)
Jain, Rashmi (Sanford Children's Specialty Clinic)
Evans-Molina, Carmella (Indiana University School of Medicine)
DiMeglio, Linda (Indiana University School of Medicine)
Ismail, Heba M. (Indiana University School of Medicine)
Dabelea, Dana (University of Colorado Anschutz Medical Campus)
Johnson, Randi K. (Colorado School of Public Health)
Urazbayeva, Marzhan (Baylor College of Medicine (Houston, Estats Units d'Amèrica))
Wentworth, John (University of Melbourne)
Griffin, Kurt J. (Sanford Research)
Sims, Emily K. (Indiana University School of Medicine)
Franks, Paul W. (Medical Science. Novo Nordisk Foundation)
Rich, Stephen S. (University of Virginia)
Wagner, Robert (Heinrich Heine University Düsseldorf)
Vilsbøll, Tina (University of Copenhagen)
Vesco, Kimberly K. (Kaiser Permanente Northwest)
Udler, Miriam S. (Harvard Medical School)
Tuomi, Tiinamaija (University of Helsinki)
Sweeting, Arianne (Royal Prince Alfred Hospital)
Sherr, Jennifer L. (Yale School of Medicine)
Semple, Robert K. (University of Edinburgh)
Reynolds, Rebecca M. (University of Edinburgh)
Redman, Leanne M. (Pennington Biomedical Research Center)
Pratley, Richard E. (AdventHealth Translational Research Institute)
Pop-Busui, Rodica (University of Michigan)
Pollin, Toni I. (University of Maryland School of Medicine)
Perng, Wei (University of Colorado Anschutz Medical Campus)
Pearson, Ewan R. (University of Dundee)
Ozanne, Susan E. (University of Cambridge)
Owen, Katharine R. (University of Oxford)
Oram, Richard (Royal Devon University Healthcare NHS Foundation Trust)
Murphy, Rinki (Te Whatu Ora Counties. Health New Zealand)
Mohan, Viswanathan (Dr. Mohan's Diabetes Specialities Centre)
Misra, Shivani (Imperial College Healthcare National Health Service Trust (Londres, Regne Unit))
Meigs, James B. (Broad Institute)
Mathioudakis, Nestoras (Johns Hopkins University)
Mathieu, Chantal (University Hospital Leuven)
Ma, Ronald C.W. (Hong Kong Institute of Diabetes and Obesity)
Loos, Ruth J.F. (Charles Bronfman Institute for Personalized Medicine)
Lim, Siew S. (Monash University)
Laffel, Lori M. (Harvard Medical School)
Kwak, Soo Heon (Seoul National University Hospital)
Josefson, Jami L. (Northwestern University Feinberg School of Medicine)
Hood, Korey K. (Stanford University School of Medicine)
Hivert, Marie-France (Universite de Sherbrooke)
Hirsch, Irl B. (University of Washington School of Medicine)
Hattersley, Andrew T. (Royal Devon University Healthcare NHS Foundation Trust)
Griffin, Kurt (Sanford Research)
Greeley, Kurt W. (University of Chicago)
Gottlieb, Peter A. (University of Colorado Anschutz Medical Campus)
Gomez, Maria F. (Aarhus University)
Gloyn, Anna L. (Stanford University)
Florez, Jose C. (Harvard Medical School)
Dennis, John M. (University of Exeter Medical School)
Costacou, Tina (University of Pittsburgh)
Boyle, Kristen (University of Colorado Anschutz Medical Campus)
Billings, Liana K. (University of Chicago)
Brown, Rebecca J. (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Philipson, Louis H. (University of Chicago)
Nolan, John J. (Wexford General Hospital)
Eckel, Robert H. (University of Colorado Anschutz Medical Campus)
Sherifali, Diana (McMaster University (Canadà))
Mixter, Emily (University of Chicago)
Mekonnen, Eskedar Getie (University of Antwerp)
Gruber, Eskedar Getie (American Diabetes Association)
Fawcett, Andrea J. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica))
de Souza, Russell (McMaster University (Canadà))
Auh, Sungyoung (National Institutes of Health (Bethesda, Estats Units d'Amèrica))
Zhu, Yeyi (University of California San Francisco)
Zhang, Cuilin (National University of Singapore)
Saint-Martin, Cécile (Sorbonne University)
Provenzano, Michele (Alma Mater Studiorum University of Bologna)
Pomares-Millan, Hugo (Geisel School of Medicine at Dartmouth (Hanover, Estats Units d'Amèrica))
Njølstad, Pål Rasmus (Haukeland University Hospital (Bergen, Noruega))
Nakabuye, Mariam (University of Copenhagen)
Molnes, Janne (Haukeland University Hospital (Bergen, Noruega))
McGovern, Andrew (University of Exeter Medical School)
Maloney, Kristin A. (University of Maryland School of Medicine)
Flanagan, Sarah E. (University of Exeter Medical School)
de Franco, Elisa (University of Exeter Medical School)
Aukrust, Ingvild (Haukeland University Hospital (Bergen, Noruega))
Polak, Michel (Université de Paris)
Beltrand, Jacques (Université de Paris)
Zhou, Shao J. (University of Adelaide)
Zhang, Yingchai (The Chinese University of Hong Kong)
Yu, Gechang (The Chinese University of Hong Kong)
White, Sara L. (Guy's and St Thomas' Hospitals NHS Foundation Trust)
Hannah, Wesley (Madras Diabetes Research Foundation)
Vatier, Camille (Saint-Antoine University Hospital)
Van der Schueren, Bart (University Hospitals Leuven (Bèlgica))
Ukke, Gebresilasea Gendisha (Monash University)
Tye, Sok Cin (University Medical Center Groningen)
Taylor, Rachael (University of Newcastle)
Støy, Julie (Aarhus University Hospital (Aarhus, Dinamarca))
Stefan, Norbert (Helmholtz Center Munich)
Steck, Andrea K. (University of Colorado Anschutz Medical Campus)
Steenackers, Nele (KU Leuven)
Stanislawski, Maggie A. (University of Colorado Anschutz Medical Campus)
Sheu, Wayne Huey-Herng (Taipei Veterans General Hospital)
Selvin, Elizabeth (Johns Hopkins Bloomberg School of Public Health)
Scholtens, Denise M. (Northwestern University Feinberg School of Medicine)
Sarkar, Sudipa (Johns Hopkins University)
Kanbour, Sarah (AMAN Hospital)
Santhakumar, Vanessa (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica))
Ried-Larsen, Mathias (University of Southern Denmark)
Ray, Debashree (Johns Hopkins Bloomberg School of Public Health)
Quinteros, Alejandra (The University of Adelaide)
Powe, Camille E. (Harvard Medical School)
Petrie, John R. (University of Glasgow)
Perez, Dianna (Indiana University School of Medicine)
Pazmino, Sofia (KU Leuven)
Pathirana, Maleesa (The University of Adelaide)
Pankow, James S. (University of Minnesota)
Onengut-Gumuscu, Suna (University of Virginia)
Motala, Ayesha A. (University of KwaZulu-Natal)
Morton, Robert W. (Medical Science. Novo Nordisk Foundation)
Lowe, William L. (Northwestern University Feinberg School of Medicine)
Liu, Kai (The University of Adelaide)
Libman, Ingrid M. (UPMC Children's Hospital of Pittsburgh)
Leung, Gloria K.W. (Monash University)
Leong, Aaron (Massachusetts General Hospital (Boston))
Koivula, Robert W. (University of Oxford)
Jones, Angus G. (Royal Devon University Healthcare NHS Foundation Trust)
Huang, Chuiguo (The Chinese University of Hong Kong)
Hansen, Torben (University of Copenhagen)
Habibi, Nahal (The University of Adelaide)
Guasch-Ferré, Marta (University of Copenhagen)
Grieger, Jessica A. (The University of Adelaide)
Goodarzi, Mark O. (Cedars-Sinai Medical Center)
Gitelman, Stephen E. (University of California at San Francisco)
Fitzpatrick, Stephanie L. (Northwell Health)
Fitipaldi, Hugo (Lund University)
Fernández-Balsells, María Mercè (Hospital Universitari de Girona Doctor Josep Trueta)
Dudenhöffer-Pfeifer, Monika (Lund University)
DiMeglio, Linda A. (Indiana University School of Medicine)
Dickens, Laura T. (University of Chicago)
Deutsch, Aaron J. (Harvard Medical School)
Dawed, Adem Y. (University of Dundee)
Clemmensen, Christoffer (University of Copenhagen)
Chivers, Sian C. (King's College London)
Chikowore, Tinashe (University of the Witwatersrand)
Cheng, Feifei (Chongqing Medical University)
Chen, Mingling (Monash University)
Bonham, Maxine P. (Monash University)
Andersen, Mette K. (University of Copenhagen)
Amouyal, Chloé (Sorbonne Université)
Young, Katherine (University of Exeter Medical School)
Yamamoto, Jennifer M. (University of Manitoba)
Wong, Jessie J. (Stanford University School of Medicine)
Wang, Caroline C. (Johns Hopkins Bloomberg School of Public Health)
Wallace, Amelia S. (Johns Hopkins Bloomberg School of Public Health)
Tosur, Mustafa (Children's Nutrition Research Center. USDA/ARS)
Thuesen, Anne Cathrine B. (University of Copenhagen)
Tam, Claudia Ha-ting (The Chinese University of Hong Kong)
Takele, Wubet Worku (Monash University)
Svalastoga, Pernille (Haukeland University Hospital (Bergen, Noruega))
Sevilla-Gonzalez, Magdalena (Massachusetts General Hospital (Boston))
Semnani-Azad, Zhila (Harvard T.H. Chan School of Public Health)
Schön, Martin (Slovak Academy of Sciences)
Rooney, Mary R. (Johns Hopkins Bloomberg School of Public Health)
Raghavan, Sridharan (University of Colorado School of Medicine)
Prystupa, Katsiaryna (German Center for Diabetes Research (DZD))
Pilla, Scott J. (Johns Hopkins University Bloomberg School of Public Health)
Patel, Kashyap Amratlal (University of Exeter Medical School)
Ozkan, Bige (Johns Hopkins School of Medicine)
Naylor, Rochelle N. (University of Chicago)
Most, Jasper (Zuyderland Medical Center (Heerlen, Països Baixos))
Morieri, Mario Luca (University of Padova)
Miller, Rachel G. (University of Pittsburgh)
Mclennan, Niamh-Maire (University of Edinburgh)
Massey, Robert (University of Dundee)
Männistö, Jonna M.E. (University of Eastern Finland)
Lim, Lee-Ling (Chinese University of Hong Kong)
Kreienkamp, Raymond J. (Boston Children's Hospital (Boston, Estats Units d'Amèrica))
Kettunen, Jarno L.T. (University of Helsinki)
Kahkoska, Anna R. (University of North Carolina at Chapel Hill)
Jacobsen, Laura M. (University of Florida)
Ikle, Jennifer M. (Stanford University)
Hughes, Alice (University of Exeter Medical School)
Haider, Eram (University of Dundee)
Gaillard, Romy (Erasmus Medical Center)
Gingras, Véronique (Sainte-Justine University Hospital Center)
Gillard, Pieter (University Hospital Leuven)
Francis, Ellen C. (Rutgers School of Public Health)
Duan, Daisy (Johns Hopkins University School of Medicine)
Cromer, Sara J. (Harvard Medical School)
Corcoy i Pla, Rosa (Institut de Recerca Sant Pau)
Colclough, Kevin (University of Exeter Medical School)
Clark, Amy L. (SSM Health Cardinal Glennon Children's Hospital)
Bodhini, Dhanasekaran (Madras Diabetes Research Foundation)
Benham, Jamie L. (University of Calgary)
Aiken, Catherine (University of Cambridge)
Ahmad, Abrar (Lund University)
Merino, Jordi (Massachusetts General Hospital (Boston))
Tobias, Deirdre K. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies. We systematically reviewed PubMed and EMBASE databases (6/14/2022) assessing 10 years of original research examining relationships between autoantibodies and heterogeneity before, at, after diagnosis, and in response to disease-modifying therapies in individuals at-risk or within 1 year of T1D diagnosis. A critical appraisal checklist tool for cohort studies was modified and used for risk of bias assessment. Here we show that 152 studies that met extraction criteria most commonly characterized heterogeneity before diagnosis (91/152). Autoantibody type/target was most frequently examined, followed by autoantibody number. Recurring themes included correlations of autoantibody number, type, and titers with progression, differing phenotypes based on order of autoantibody seroconversion, and interactions with age and genetics. Only 44% specifically described autoantibody assay standardization program participation. Current evidence most strongly supports the application of autoantibody features to more precisely define T1D before diagnosis. Our findings support continued use of pre-clinical staging paradigms based on autoantibody number and suggest that additional autoantibody features, particularly in relation to age and genetic risk, could offer more precise stratification. To improve reproducibility and applicability of autoantibody-based precision medicine in T1D, we propose a methods checklist for islet autoantibody-based manuscripts which includes use of precision medicine MeSH terms and participation in autoantibody standardization workshops.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Communications Medicine, Vol. 4 Núm. 1 (december 2024) , p. 66, ISSN 2730-664X

DOI: 10.1038/s43856-024-00478-y
PMID: 38582818

18 p, 1.5 MB

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