Changes in choroidal thickness quantified by Optical Coherence Tomography across cognitive impairment : data from the NORFACE cohort
Castilla-Martí, Luis (Universitat Autònoma de Barcelona. Departament de Cirurgia)
García-Sánchez, Ainhoa (Universitat Internacional de Catalunya)
Martínez, Joan (Universitat Internacional de Catalunya)
Rosende-Roca, Maitée (Universitat Internacional de Catalunya)
Vargas, Liliana (Universitat Internacional de Catalunya)
Tartari, Juan Pablo (Universitat Internacional de Catalunya)
Casales, Federico (Universitat Internacional de Catalunya)
Rodríguez, José Nelet (Universitat Internacional de Catalunya)
Bein, Natali (Universitat Internacional de Catalunya)
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Pérez-Cordón, Alba (Universitat Internacional de Catalunya)
Muñoz, Nathalia (Universitat Internacional de Catalunya)
García-Gutiérrez, Fernando (Universitat Internacional de Catalunya)
Blazquez-Folch, Josep (Universitat Internacional de Catalunya)
Miguel, Andrea (Universitat Internacional de Catalunya)
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Puerta, Raquel (Universitat Internacional de Catalunya)
Olivé, Clàudia (Universitat Internacional de Catalunya)
Capdevila, Maria (Universitat Internacional de Catalunya)
Muñoz-Morales, Álvaro (Universitat Internacional de Catalunya)
Bayón-Buján, Paula (Universitat Internacional de Catalunya)
Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Fernández, Victoria (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Ruiz Laza, Agustín (University of Texas Health Science Center at San Antonio)
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (Madrid))
Castilla Marti, Miguel (Vista Alpina Eye Clinic (Suïssa))
Marquié, Marta (Universitat Internacional de Catalunya)

Data:	2024
Resum:	Optical coherence tomography (OCT) enables high-resolution imaging of ocular structures in health and disease. Choroid thickness (CT) is a key vascular retinal parameter that can be assessed by OCT and might be relevant in the evaluation of the vascular component of cognitive decline. We aimed to investigate CT changes in a large cohort of individuals cognitive unimpaired (CU), with mild cognitive impairment due to Alzheimer's (MCI-AD), mild cognitive impairment due to cerebrovascular disease (MCI-Va), Alzheimer's disease dementia (ADD), and vascular dementia (VaD). Clinical, demographical, ophthalmological and OCT data from the Neuro-ophthalmological Research at Fundació ACE (NORFACE) project were analyzed. CT was assessed in the macula across nine Early Treatment Diabetic Retinopathy Study (ETDRS) quadrants, average thickness, total volume, and subfoveal choroidal thickness. Differences of CT among the five diagnostic groups were assessed in a multivariate regression model, adjusting for demographic and cardiovascular risk factors and OCT image quality. A comparison between manual and automatic CT measurements in a subset of participants was also performed. The study cohort comprised 1,280 participants: 301 CU, 196 MCI-AD, 112 MCI-Va, 578 ADD, and 93 VaD. CT was significantly increased in individuals with cognitive impairment compared to those CU, particularly in the VaD and MCI-Va groups and in the peripheral ETDRS regions. No significant differences were found in inner superior, center and subfoveal choroidal thickness. The interaction of sex and diagnosis had no effect in differentiating CT. Mini-Mental State Examination (MMSE) scores were not correlated to CT. Manual and automated CT measurements showed good reliability. Our findings indicated that peripheral choroidal thickening, especially in patients with cerebrovascular disease, may serve as a potential choroidal biomarker for cognitive decline and suggest different pathogenic pathways in AD and VaD. Further research is required to explore CT as a reliable ocular biomarker for cognitive impairment. The online version contains supplementary material available at 10. 1186/s13195-024-01616-3.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Choroidal thickness ; Optical coherence tomography ; Alzheimer's disease ; Vascular dementia ; Biomarkers ; NORFACE cohort
Publicat a:	Alzheimer's research & therapy, Vol. 16 (november 2024) , ISSN 1758-9193

DOI: 10.1186/s13195-024-01616-3
PMID: 39550564

20 p, 1.3 MB

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