The introduction of a highly virulent PRRSV strain in pig farms is associated with a change in the pattern of influenza A virus infection in nurseries
Domingo Carreño, Ivan (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Serena, Maria Soledad (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Martin-Valls, Gerard (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Clilverd, Hepzibar (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Aguirre Molins, Laia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Cortey, Martí (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data:	2024
Descripció:	1 pàg.
Resum:	The present study aimed to determine the dynamics of influenza A virus (IAV) infection in two endemically infected farms (F1 and F2), where a longitudinal follow-up of piglets was performed from birth to 8-12 weeks of age. During the study, a highly virulent isolate of porcine reproductive and respiratory syndrome virus (PRRSV) was introduced on both farms. This allowed us to examine the impact of such introduction on the patterns of infection, disease, and the antibody response of pigs to IAV infection. The introduction of the new PRRSV strain coincided with a change in the dynamics of IAV infection on both farms. In F1, the cumulative incidence of IAV increased from 20% before the outbreak to 67. 5%, together with the existence of animals that tested positive for IAV (RT‒qPCR) in nasal swabs for two or more consecutive samples. In F2, the cumulative incidence of IAV increased from 50% before the PRRSV outbreak to 70%, and the proportion of prolonged IAV shedders increased sharply. Additionally, some animals were infected with the same IAV twice during the observation period. In contrast to previous reports, our study revealed that prolonged shedding was not related to the titres of maternally derived antibodies at the time of infection but was significantly (p < 0. 05) related to PRRSV infection status. Notably, both before and after the PRRSV outbreak, a high proportion of IAV-infected piglets did not seroconvert, which was significantly (p < 0. 05) related to the hemagglutination inhibition titres against IAV when infected.
Ajuts:	Agencia Estatal de Investigación PCI2020-120688-2 Ministerio de Ciencia e Innovación FPU18/04259
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Coinfection ; Influenza A virus ; Maternally derived antibodies ; Porcine reproductive and respiratory syndrome virus
Publicat a:	Veterinary research, Vol. 55 Núm. 1 (2024) , p. 147, ISSN 1297-9716

DOI: 10.1186/s13567-024-01406-7
PMID: 39522027

13 p, 1.7 MB

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