Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Simoes, Margarida Pires (National Institute of Public Health and the Environment. European Centre for Disease Prevention and Control (ECDC))
Hodcroft, Emma B. (Geneva University Hospital and Faculty of Medicine. Swiss Institute of Bioinformatics. Institute of Social and Preventive Medicine)
Simmonds, Peter (University of Oxford)
Albert, Jan (Karolinska University Hospital)
Alidjinou, Enagnon K. (University of Lille)
Ambert-Balay, Katia (University Hospital of Dijon Bourgogne)
Andrés, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Antón Pagarolas, Andrés, 1976- 1976- (Vall d'Hebron Institut de Recerca (VHIR))
Auvray, Christelle (University Hospital of Dijon Bourgogne)
Bailly, Jean-Luc (University of Clermont Auvergne)
Baldanti, Fausto (Fondazione IRCCS Policlinico San Matteo. Università di Pavia)
Bastings, Capser (Eurofins-PAMM)
Beard, Stuart (Radiation Effects Department, UK Health Security Agency)
Berengua, Carla (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Berginc, Natasa (Environment)
Bloemen, Mandy (Rega Institute for Medical Research)
Blomqvist, Soile (Finnish Institute for Health and Welfare)
Bosma, Froukje (Laboratory for Medical Microbiology and Public Health)
Böttcher, Sindy (Robert Koch Institute)
Bubba, Laura (European Non-Polio Enterovirus Network)
Buderus, Stafan (GFO Kliniken Bonn - Betriebsstätte St. Marien)
Cabrerizo, Maria (Instituto de Salud Carlos III)
Calvo, Cristina (Hospital Universitario La Paz (Madrid))
Celma, Cristina (Radiation Effects Department, UK Health Security Agency)
Ceriotti, Ferruccio (Istituto Nazionale per lo Studio e la Cura dei Tumori)
Clark, Gemma (Nottingham University Hospitals NHS Trust (Regne Unit))
Costa, Inës (Instituto Nacional de Saude Dr. Ricardo Jorge)
Coste-Burel, Marianne (Centre Hospitalier Universitaire de Nantes Hôtel Dieu)
Couderé, Karen (Elisabeth Tweesteden Hospital)
Cremer, Jeroen (National Institute of Public Health and the Environment)
del Cuerpo Casas, Margarita (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Daehne, Theo (University of Freiburg)
De Beer, Jessica (Laboratory for Medical Microbiology and Public Health)
De Ceano-Vivas, Maria (Hospital Universitario La Paz (Madrid))
De Gascun, Cillian (University College Dublin)
De Rougemont, Alexis (University Hospital of Dijon Bourgogne)
Dean, Jonathan (University College Dublin)
Dembinski, Jennifer L. (Norwegian Institute of Public Health)
Diedrich, Sabine (Robert Koch Institute)
Diez-Domingo, Javier (Generalitat Valenciana)
Dillner, Lena (Folkhälsomyndigheten)
Dorenberg, Dagny H. (Norwegian Institute of Public Health)
Ducancelle, Alexandra (Angers University Hospital (Angers, França))
Dudman, Susanne (Oslo University Hospital. University of Oslo)
Dyrdak, Robert (Karolinska University Hospital)
Eis-Huebinger, Anna-Maria (University Bonn)
Falces-Romero, Iker (Hospital Universitario La Paz (Madrid))
Farkas, Agnes (National Institute for Public Health)
Feeney, Susan (Royal Victoria Hospital)
Fernandez-Garcia, Maria D. (Instituto de Salud Carlos III)
Flipse, Jacky (Laboratory for Medical Microbiology and Immunology)
Franck, Kristina T. (World Health Organization)
Galli, Cristina (University of Milan)
Garrigue, Isabelle (Centre Hospitalier Universitaire Bordeaux)
Geeraedts, Felix (Laboratory for Medical Microbiology and Public Health)
Georgieva, Irina (National Center of Infectious and Parasitic Diseases Bulgaria)
Giardina, Federica (University of Pavia)
Guiomar, Raquel (Instituto Nacional de Saude Dr. Ricardo Jorge)
Hauzenberger, Elenor (Folkhälsomyndigheten)
Heikens, Esther (St Jansdal Hospital)
Henquell, Cécille (University of Clermont Auvergne. Centre Hospitalier Universitaire de Clermont-Ferrand)
Hober, Didier (University of Lille)
Hönemann, Mario (Leipzig University)
Howson-Wells, Hannah (Nottingham University Hospitals NHS Trust (Regne Unit))
Hruškar, Željka (Croatian Institute of Public Health)
Ikonen, Niina (Finnish Institute for Health and Welfare)
Imbert, Berthemarie (Centre Hospitalier Universitaire de Nantes Hôtel Dieu)
Jansz, Arjan R. (Eurofins-PAMM)
Jeannoël, Marion (Hospices Civils de Lyon)
Jiřincová, Helena (National Institute of Public Health Prague)
Josset, Laurence (Hospices Civils de Lyon)
Keeren, Kathrin (Robert Koch Institute)
Kramer-Lindhout, Naomie (Admiraal de Ruijter Hospital)
Krokstad, Sidsel (St Olav's University Hospital)
Lazrek, Mouna (University of Lille)
Le Guillou-Guillemette, Hélène (Angers University Hospital (Angers, França))
Lefeuvre, Caroline (Angers University Hospital (Angers, França))
Lind, Andreas (Oslo University Hospital (Oslo, Noruega))
Lunar, Maja M. (Univerza V Ljubljani)
Maier, Melanie (Leipzig University)
Marque-Juillet, Stéphanie (Centre Hospitalier de Versailles)
McClure, C. Patrick (University of Nottingham)
McKenna, James (Royal Victoria Hospital)
Meijer, Adam (National Institute of Public Health and the Environment)
Menasalvas Ruiz, Ana (Hosptial Universitario Virgen de la Arraixaca)
Mengual-Chuliá, Beatriz (Generalitat Valenciana)
Midgley, Sofie (World Health Organization)
Mirand, Audrey (University of Clermont Auvergne. Centre Hospitalier Universitaire de Clermont-Ferrand)
Molenkamp, Richard (Erasmus Medical Center)
Montes, Milagrosa (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Moreno-Docón, Antonio (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Morley, Ursula (University College Dublin)
Murk, Jean Luc (Elisabeth Tweesteden Hospital)
Navascués-Ortega, Ana (Hospital Universitario de Navarra)
Nijhuis, Roel (Meander Medical Center)
Nikolaeva-Glomb, Lubomira (National Center of Infectious and Parasitic Diseases Bulgaria)
Nordbø, Svein A. (Norwegian University of Science and Technology)
Numanovic, Sanela (Norwegian Institute of Public Health)
Oggioni, Massimo (Azienda Socio Sanitaria Territoriale della Brianza)
Oñate Vergara, Eider (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Pacaud, Jordi (Centre Hospitalier Universitaire Bordeaux)
Pacreau, Marie L. (Centre Hospitalier de Versailles)
Panning, Marcus (University of Freiburg)
Pariani, Elena (University of Milan)
Pekova, Lili (University Hospital Prof Dr Stoyan Kirkovich AD)
Pellegrinelli, Laura (University of Milan)
Petrovec, Miroslav (Univerza V Ljubljani)
Pietsch, Corinna (Leipzig University)
Pilorge, Léa (CHU Brest)
Piñeiro, Luis (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Piralla, Antonio (Fondazione IRCCS Policlinico San Matteo (Itàlia))
Poljak, Mario (Univerza V Ljubljani)
Prochazka, Birgit (Austrian Agency for Health and Food Safety)
Rabella, Núria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Rahamat-Langendoen, Janette C. (Erasmus Medical Center)
Rainetova, Petra (National Institute of Public Health Prague)
Reynders, Marijke (Algemeen Ziekenhuis Sint-Jan (AZ Sint-Jan))
Riezebos-Brilman, Annelies (Laboratory for Medical Microbiology and Public Health)
Roorda, Lieuwe (Maasstad Hospital)
Savolainen-Kopra, Carita (Finnish Institute for Health and Welfare)
Schuffenecker, Isabelle (Hospices Civils de Lyon)
Smeets, Leo C. (Reinier Haga Medical Diagnostic Center)
Stoyanova, Asya (National Center of Infectious and Parasitic Diseases Bulgaria)
Stefic, Karl (University of Tours-François Rabelais)
Swanink, Caroline (Laboratory for Medical Microbiology and Immunology)
Tabain, Irena (Croatian Institute of Public Health)
Tjhie, Jeroen (Eurofins-PAMM. Elisabeth Tweesteden Hospital)
Thouault, Luc (CHU Brest)
Tumiotto, Camille (Centre Hospitalier Universitaire Bordeaux)
Uceda Renteria, Sara (Istituto Nazionale per lo Studio e la Cura dei Tumori)
Uršič, Tina (Univerza V Ljubljani)
Vallet, Sophie (CHU Brest)
Van Ranst, Marc (Rega Institute for Medical Research)
Van Wunnik, Peter (Reinier Haga Medical Diagnostic Center)
Verweij, Jaco J. (Elisabeth Tweesteden Hospital)
Vila, Jorgina (Hospital Universitari Vall d'Hebron)
Wintermans, Bas (Admiraal de Ruijter Hospital)
Wollants, Elke (Rega Institute for Medical Research)
Wolthers, Katja C. (Amsterdam UMC - University of Amsterdam)
Xavier López-Labrador, F. (Generalitat Valenciana)
Fischer, Thea K. (Nordsjællands Hospital - Hillerød. University of Copenhagen)
Harvala, Heli (University of Oxford)
Benschop, Kimberley S. M. (National Institute of Public Health and the Environment)
Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

Data:	2024
Resum:	Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6. 8%) EV-positive samples of which 1004 (9. 6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78. 9% of infections were reported in children (0-5 years); and 37. 9% of cases were hospitalized. Acute respiratory distress was commonly noted (93. 1%) followed by fever (49. 4%). Neurological problems were observed in 6. 4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages. The study describes a large-scale EV-D68 European upsurge during the fall-winter season of 2021-2022 with severe clinical impact, including respiratory distress and neurological problems such as acute flaccid myelitis, and the emergence of novel B3-derived lineages.
Ajuts:	Instituto de Salud Carlos III PI18-00035
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Enterovirus D68 (EV-D68) ; Respiratory infection ; Nonpolio enterovirus (NPEV) ; European Non-Polio Enterovirus Network (ENPEN) ; Acute flaccid myelitis (AFM)
Publicat a:	The journal of infectious diseases, Vol. 230 N. 4 (October 2024) , p. e917-e928, ISSN 1537-6613

DOI: 10.1093/infdis/jiae154
PMID: 38547499

12 p, 796.9 KB

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