Long-term safety of OnabotulinumtoxinA treatment in chronic migraine patients : a five-year retrospective study
Navarro-Pérez, M.P. (Universidad de Zaragoza)
González-Quintanilla, V. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Muñoz-Vendrell, Albert (Hospital Universitari de Bellvitge)
Madrigal, E. (Hospital Universitario de Burgos)
Alpuente, Alicia (Vall d'Hebron Institut de Recerca (VHIR))
Latorre, G. (Hospital Universitario de Fuenlabrada ( Madrid))
Molina, F. (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Monzón, M.J. (Hospital Universitario Miguel Servet (Saragossa))
Medrano, V. (Hospital General Universitario de Elda)
García-Azorín, D. (Hospital Clínico Universitario de Valladolid)
González-Oria, Carmen (Hospital Clínico Universitario Virgen del Rocío)
Gago-Veiga, A. (Hospital Universitario de la Princesa (Madrid))
Velasco, F. (Hospital Universitario de Cruces (Barakaldo, País Basc))
Beltrán, Isabel (Hospital General Universitario de Alicante (Alacant, País Valencià))
Morollón, N. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Viguera, J. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Casas-Limón, J. (Hospital Universitario Fundación Alcorcón)
Rodríguez-Vico, J. (Hospital Universitario Fundación Jiménez Díaz)
Cuadrado Godia, Elisa (Hospital del Mar (Barcelona, Catalunya))
Irimia, Pablo (Clínica Universidad de Navarra)
Iglesias, F. (Hospital Universitario de Burgos)
Guerrero-Peral, Ángel L. (Hospital Clínico Universitario de Valladolid)
Belvís, Roberto (Institut de Recerca Sant Pau)
Pozo-Rosich, Patricia (Vall d'Hebron Institut de Recerca (VHIR))
Pascual, J. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Santos-Lasaosa, S. (Universidad de Zaragoza)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Background: Real-world studies have shown the sustained therapeutic effect and favourable safety profile of OnabotulinumtoxinA (BoNTA) in the long term and up to 4 years of treatment in chronic migraine (CM). This study aims to assess the safety profile and efficacy of BoNTA in CM after 5 years of treatment in a real-life setting. Methods: We performed a retrospective chart review of patients with CM in relation to BoNTA treatment for more than 5 years in 19 Spanish headache clinics. We excluded patients who discontinued treatment due to lack of efficacy or poor tolerability. Results: 489 patients were included [mean age 49, 82. 8% women]. The mean age of onset of migraine was 21. 8 years; patients had CM with a mean of 6. 4 years (20. 8% fulfilled the aura criteria). At baseline, patients reported a mean of 24. 7 monthly headache days (MHDs) and 15. 7 monthly migraine days (MMDs). In relation to effectiveness, the responder rate was 59. 1% and the mean reduction in MMDs was 9. 4 days (15. 7 to 6. 3 days; p < 0. 001). The MHDs were also reduced by 14. 9 days (24. 7 to 9. 8 days; p < 0. 001). Regarding the side effects, 17. 5% experienced neck pain, 17. 3% headache, 8. 5% eyelid ptosis, 7. 5% temporal muscle atrophy and 3. 2% trapezius muscle atrophy. Furthermore, after longer-term exposure exceeding 5 years, there were no serious adverse events (AE) or treatment discontinuation because of safety or tolerability issues. Conclusion: Treatment with BoNTA led to sustained reductions in migraine frequency, even after long-term exposure exceeding 5 years, with no evidence of new safety concerns.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	OnabotulinumtoxinA ; Chronic migraine ; Migraine ; Prevention ; Prophylaxis ; Treatment
Publicat a:	Frontiers in neurology, Vol. 15 (2024) , p. 1417831, ISSN 1664-2295

DOI: 10.3389/fneur.2024.1417831
PMID: 38938776

7 p, 288.5 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats