Development and validation of a clinical nomogram to predict prostatic inflammation in men with lower urinary tract symptoms
Gravas, S. (University of Cyprus)
De Nunzio, C. (University of Rome)
Campos Pinheiro, L. (Hospital de São José (Lisboa, Portugal))
Ponce de León Roca, Javier (Institut de Recerca Sant Pau)
Skriapas, K. (General Hospital of Larissa)
Milad, Z. (University of Cyprus)
Lombardo, R. (University of Rome)
Medeiros, M. (Hospital de São José (Lisboa, Portugal))
Makrides, P. (University of Cyprus)
Samarinas, M. (General Hospital of Larissa)
Gacci, M. (Università degli Studi di Firenze)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Background: Prostatic inflammation is an important etiological component of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). The Prostatic Inflammation Nomogram Study (PINS) aimed to develop and validate a nomogram for predicting the presence of prostatic inflammation in men with LUTS. Methods: This non-interventional, cross-sectional, prospective study was conducted in six secondary/tertiary centers across Cyprus, Greece, Italy, Portugal, and Spain. Men (≥40 years) with BPH/LUTS scheduled to undergo prostatic surgery or transrectal ultrasound-guided (TRUS) prostate biopsy were included. Fifteen demographic and clinical participant characteristics were selected as possible predictors of prostatic inflammation. The presence of inflammation (according to Irani score) in the prostatic tissue samples obtained from surgery/TRUS biopsy was determined. The effect of each characteristic on the likelihood a prostate specimen demonstrated inflammation (classified by Irani score into two categories, 0-2 [no/minimal inflammation] or 3-6 [moderate/severe inflammation]) was assessed using multiple logistic regression. A nomogram was developed and its discriminatory ability and validity were assessed. Results: In total, 423 patients (mean age 68. 9 years) were recruited. Prostate volume ultrasound (PVUS).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Prostate Cancer and Prostatic Diseases, 2024 , ISSN 1476-5608

DOI: 10.1038/s41391-024-00857-5
PMID: 38971935

6 p, 754.5 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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