Synergistic role of nanoceria on the ability of tobacco smoke to induce carcinogenic hallmarks in lung epithelial cells
Rubio Lorente, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Bach Griera, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Títol variant:	Synergistic role of nanoceria on the ability of tobacco-smoke to induce carcinogenic hallmarks in lung epithelial cells
Data:	2017
Descripció:	13 pàg.
Resum:	Aim: Since controversial results have been obtained in studies dealing with nanoceria usefulness in biomedical applications, the transforming effects of long-term exposure to nanoceria in lung epithelial cells, alone or together with cigarette smoke condensate (CSC), were evaluated. Materials & methods: In vitro cell transformation techniques were used to study several hallmarks of carcinogenesis. Morphology, cell proliferation, gene expression, cell migration, anchorage-independent cell growth and cell secretome were analyzed. Results & conclusion: Data evidence no transforming ability of nanoceria, but support a synergistic role on CSC's transforming ability. A more noticeable spindle-like phenotype, increased proliferation rate, higher degree of differentiation status dysregulation, higher migration capacity, increased anchorage-independent cell growth and higher levels of MMP-9 and cell growth promoting capability, were observed. In addition, nanoceria co-exposure exacerbates the expression of FRA-1.
Ajuts:	European Commission 310584 Agencia Estatal de Investigación BFU2016-76831-R
Drets:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	CeO2NP ; Cell transformation ; Cigarette smoke condensate co-exposure ; Lung BEAS-2B cells ; Nanoceria in vitro long-term exposure
Publicat a:	Nanomedicine, Vol. 12, issue 23 (December 2017) , p. 2623-2635, ISSN 1748-6963

DOI: 10.2217/nnm-2017-0205
PMID: 29094638

Postprint 35 p, 1.1 MB

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