EULAR recommendations for the treatment of systemic sclerosis : 2023 update
Del Galdo, F. (Leeds Teaching Hospitals Trust)
Lescoat, A. (Rennes University Hospital)
Conaghan, P.G. (Leeds Teaching Hospitals Trust)
Bertoldo, E. (Universita degli Studi di Verona)
Čolić, J. (University of Belgrade Faculty of Medicine)
Santiago, T. (Centro Hospitalar e Universitario de Coimbra EPE)
Suliman, Y.A. (Ain Alkhaleej Hospital. Alain)
Matucci-Cerinic, Marco (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS))
Gabrielli, Armando (Università Politecnica delle Marche Facoltà di Medicina e Chirurgia)
Distler, Oliver (University Hospital Zürich Center of Experimental Rheumatology)
Hoffmann-Vold, A.M. (Oslo University Hospital (Oslo, Noruega))
Castellvi, Ivan (Institut de Recerca Sant Pau)
Balbir-Gurman, A. (Rambam Health Care Campus (Haifa, Israel))
Vonk, M. (Radboud Universiteit)
Ananyeva, L. (Russian Academy of Medical Sciences)
Rednic, S. (UMF Iuliu Haţieganu Cluj-Napoca)
Tarasova, A. (Nasonova Research Institute of Rheumatology of RAMS)
Ostojic, P. (University of Belgrade Faculty of Medicine)
Boyadzhieva, V. (Medical University-Sofia)
El Aoufy, K. (Università degli Studi di Firenze)
Farrington, S. (Federation of European Scleroderma Associations)
Galetti, I. (Federation of European Scleroderma Associations)
Denton, C.P. (Royal Free Hospital)
Kowal-Bielecka, O. (Medical University of Bialystok)
Mueller-Ladner, U. (University of Giessen)
Allanore, Yannick (Université Paris Cité UFR de Médecine)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	To update the 2017 European Alliance of Associations for Rheumatology (EULAR) recommendations for treatment of systemic sclerosis (SSc), incorporating new evidence and therapies. An international task force was convened in line with EULAR standard operating procedures. A nominal group technique exercise was performed in two rounds to define questions underpinning a subsequent systematic literature review. The evidence derived was discussed and overarching principles, recommendations and future research agenda were iteratively developed with voting rounds. The task force agreed on 22 recommendations covering 8 clinical/organ domains including Raynaud's phenomenon, digital ulcers, pulmonary arterial hypertension, scleroderma renal crisis, skin fibrosis, interstitial lung disease (ILD), gastrointestinal manifestations and arthritis. Most new recommendations are related to skin fibrosis and ILD. These included novel recommendations for the use of mycophenolate mofetil, nintedanib, rituximab and tocilizumab for the treatment of these crucial disease manifestations. The recommendations also included first-line and second-line interventions, providing increased utility for rheumatology practitioners. Important additions to the future research agenda included consideration of novel interventions for the management of vascular, musculoskeletal and gastrointestinal manifestations and calcinosis, as well as for the local management of digital ulcers. These updated recommendations include the first set of synthetic and biological targeted therapies recommended for key fibrotic manifestations of SSc as well as first-line combination treatment for newly diagnosed pulmonary artery hypertension and prioritise a new research agenda for the coming years.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Annals of the rheumatic diseases, Vol. 84 Núm. 1 (january 2025) , p. 29-40, ISSN 1468-2060

DOI: 10.1136/ard-2024-226430
PMID: 39874231

12 p, 2.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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