Quantitative EEG biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy
Lallana, Sofía (Universitat Autònoma de Barcelona)
López Maza, Samuel (Vall d'Hebron Institut de Recerca (VHIR))
Ortega, Gemma (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona)
Fonseca, Elena (Vall d'Hebron Institut de Recerca (VHIR))
Quintana, Manuel (Vall d'Hebron Institut de Recerca (VHIR))
Abraira del Fresno, Laura (Vall d'Hebron Institut de Recerca (VHIR))
Bellido, Enric (Vall d'Hebron Institut de Recerca (VHIR))
Campos Fernández, Daniel (Vall d'Hebron Institut de Recerca (VHIR))
Santamarina Perez, Estevo (Universitat Autònoma de Barcelona. Departament de Medicina)
Ruiz Laza, Agustín (Ace Alzheimer Center Barcelona)
Tárraga, Lluís (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona)
Boada, Mercè (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona)
Toledo, Manuel (Vall d'Hebron Institut de Recerca (VHIR))

Data:	2025
Resum:	Background: This study aimed to explore quantitative electroencephalography (qEEG) biomarkers of cognitive performance in drug-resistant temporal lobe epilepsy (TLE) and analyze their relationship with clinical characteristics. Methods: Cross-sectional study including adult patients with drug-resistant TLE and a control group. Resting-state, eyes-closed qEEG samples were analyzed using the fast Fourier transform approach. Power spectral density was calculated for four frequency bands: delta (1-3. 9 Hz), theta (4-7. 9 Hz), alpha (8-12. 9 Hz), and beta (13-18 Hz). Neuropsychological tests were administered to TLE patients. Results: Twenty-nine TLE patients (mean age 42 ± 8. 2 years; 44. 8 % women) and 23 age- and sex-matched controls were enrolled. Clinically significant cognitive impairment was found in 86. 2 % of patients (58. 6 % amnestic). Compared to controls, TLE patients showed increased ipsilateral power spectral density for the theta (p = 0. 045), alpha (p = 0. 023) and beta bands in the anterior region (p = 0. 029) and for the delta band in the posterior region (p = 0. 03). Alpha/theta ratio (ATR) was lower in the posterior quadrant of the epileptogenic hemisphere (p = 0. 013), and higher seizure frequency correlated with a lower ATR in the ipsilateral temporal region (r: -0. 425; p = 0. 021). Patients with amnestic cognitive impairment exhibited higher power spectral density across most frequency bands (p < 0. 005). Impaired verbal memory and executive function were associated with increased power density. Conclusion: Increased power spectral density was evident in all frequency bands in the epileptogenic hemisphere, particularly in those patients with amnestic cognitive impairment. Moreover, higher seizure frequency correlated with a lower ATR in the temporal region. Power spectral analysis can provide useful information in drug-resistant TLE patients.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Electroencephalography ; Brain waves ; Neurocognitive disorders ; Drug resistant epilepsy ; Temporal lobe epilepsy
Publicat a:	Epilepsy and Behavior, Vol. 165 (April 2025) , ISSN 1525-5069

DOI: 10.1016/j.yebeh.2025.110323

Disponible a partir de: 2026-04-30 Postprint

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