Decoding the historical tale : COVID-19 impact on haematological malignancy patients-EPICOVIDEHA insights from 2020 to 2022
Salmanton-García, Jon (German Centre for Infection Research (DZIF))
Marchesi, Francesco (IRCCS Regina Elena National Cancer Institute)
Farina, Francesca (IRCCS Ospedale San Raffaele (Milà, Itàlia))
Weinbergerová, Barbora (Masaryk University Hospital Brno)
Itri, Federico (San Luigi Gonzaga Hospital - Orbassano (Itàlia))
Dávila-Valls, Julio (Hospital Nuestra Señora de Sonsoles (Àvila))
Martín-Pérez, Sonia (Hospital Nuestra Señora de Sonsoles (Àvila))
Glenthøj, Andreas (Copenhagen University Hospital - Rigshospitalet)
Hersby, Ditte Stampe (Copenhagen University Hospital - Rigshospitalet (Dinamarca))
Gomes da Silva, Maria (Portuguese Institute of Oncology (Portugal))
Nunes Rodrigues, Raquel (Portuguese Institute of Oncology (Portugal))
Lopez-Garcia, Alberto (Hospital Universitario Fundación Jiménez Díaz)
Córdoba, Raúl (Hospital Universitario Fundación Jiménez Díaz)
Bilgin, Yavuz M. (ADRZ Admiral de Ruyter Medical Center (Goes, Països Baixos))
Falces-Romero, Iker (Instituto de Salud Carlos III)
El-Ashwah, Shaimaa (Mansoura University (Egipte))
Emarah, Ziad (xKing Abdullah Medical City (Aràbia Saudita))
Besson, Caroline (Université Paris-Saclay (França))
Kohn, Milena (Université Paris-Saclay (França))
van Doesum, Jaap A. (University Medical Center Groningen (Països Baixos))
Ammatuna, Emanuele (University Medical Center Groningen (Països Baixos))
Marchetti, Monia (Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo (Itàlia))
Labrador, Jorge (Hospital Universitario de Burgos)
Zambrotta, Giovanni (Università Milano-Bicocca (Itàlia))
Verga, Luisa (Università Milano-Bicocca (Itàlia))
Jakšić, Ozren (University Hospital Dubrava (Zagreb, Croàcia))
Nucci, Marcio (Universidade Federal do Rio de Janeiro)
Piukovics, Klára (University of Szeged (Hongria). Department of Internal Medicine)
Cabirta, Alba (Vall d'Hebron Institut d'Oncologia)
Jiménez, Moraima (Vall d'Hebron Institut d'Oncologia)
Arellano, Elena (Universidad de Sevilla)
Espigado, Ildefonso (Universidad de Sevilla)
Blennow, Ola (Karolinska University Hospital)
Nordlander, Anna (Karolinska University Hospital)
Meers, Stef (AZ KLINA (Brasschaat, Bèlgica))
Van Praet, Jens (AZ Sint-Jan Brugge-Oostende AV (Bèlgica))
Aiello, Tommaso Francesco (Hospital Clínic i Provincial de Barcelona)
Garcia-Vidal, Carolina (Hospital Clínic i Provincial de Barcelona)
Fracchiolla, Nicola (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Sciumè, Mariarita (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Cengiz Seval, Guldane (Ankara University (Ankara, Turquia))
Žák, Pavel (University Hospital Hradec Kralove (República Txeca))
Buquicchio, Caterina (Ospedale Dimiccoli Barletta (Itàlia))
Tascini, Carlo (Azienda Sanitaria Universitaria del Friuli Centrale (Itàlia))
Gräfe, Stefanie K. (University Medical Center Hamburg-Eppendorf (Hamburg, Alemanya))
Schönlein, Martin (University Medical Center Hamburg-Eppendorf (Hamburg, Alemanya))
Adžić-Vukičević, Tatjana (COVID Hospital "Batajnica" (Belgrad, Sèrbia))
Bonuomo, Valentina (Policlinico Borgo Roma Verona (Itàlia))
Cattaneo, Chiara (ASST-Spedali Civili (Brescia, Itàlia))
Nizamuddin, Summiya (Shaukat Khanum Memorial Cancer Hospital and Research Centre (Lahore, Pakistan))
Čerňan, Martin (University Hospital Olomouc (Olomouc, República Txeca))
Plantefeve, Gaetan (Centre Hospitalier Victor DUPOUY (França))
Prin, Romane (CRA from CRC Centre Hospitalier Victor DUPOUY (França))
Szotkovski, Tomas (University Hospital Olomouc (Olomouc, República Txeca))
Collins, Graham (Oxford University Hospitals (Oxford, Anglaterra))
Dargenio, Michelina (Ospedale Vito Fazzi (Lecce, Itàlia))
Petzer, Verena (Medical University of Innsbruck (MUI)(Àustria))
Wolf, Dominik (Medical University of Innsbruck (MUI)(Àustria))
Čolović, Natasha (University Clinical Center Serbia (Belgrad, Sèrbia))
Prezioso, Lucia (Hospital University of Parma (Itàlia))
Valković, Toni (University of Rijeka (Croàcia))
Passamonti, Francesco (Ospedale di Circolo of Varese (Itàlia))
Méndez, Gustavo Adolfo (Hospital Escuela de Agudos Dr. Ramón Madariaga (Posadas, Argentina))
Sili, Uluhan (Marmara University (Turquia))
Vena, Antonio (Ospedale Policlinico San Martino (Itàlia))
Bavastro, Martina (Ospedale Policlinico San Martino (Itàlia))
Limongelli, Alessandro (Ospedale Policlinico San Martino (Itàlia))
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Ledoux, Marie-Pierre (ICANS (França))
Cvetanoski, Milche (University Clinic of Hematology (Macedònia))
Stojanoski, Zlate (University Clinic of Hematology (Macedònia))
Machado, Marina (Hospital General Universitario Gregorio Marañón)
Batinić, Josip (University of Zagreb. Faculty of Medicine)
Magliano, Gabriele (ASST Grande Ospedale Metropolitano Niguarda (Itàlia))
Biernat, Monika M. (Wroclaw Medical University (Polònia))
Pantic, Nikola (University Clinical Center of Serbia (Belgrad, Sèrbia))
Poulsen, Christian Bjørn (Zealand University Hospital (Dinamarca))
Cuccaro, Annarosa (National Cancer Institute. Fondazione 'G. Pascale'. IRCCS (Itàlia))
del Principe, Maria Ilaria (University of Rome Tor Vergata (Itàlia))
Kulasekararaj, Austin (King's College Hospital NHS Foundation Trust (Londres, Anglaterra))
Ormazabal-Vélez, Irati (Hospital Universitario de Navarra)
Busca, Alessandro (AOU Città della Salute e della Scienza di Torino)
Demirkan, Fatih (Dokuz Eylul University (Turquia))
Ijaz, Marriyam (Shaukat Khanum Memorial Cancer Hospital and Research Centre (Lahore, Pakistan))
Klimko, Nikolai (North-Western State Medical University Named after Iliá Ilich Méchnikov (Rússia))
Stoma, Igor (Gomel State Medical University (Bielorússia))
Khostelidi, Sofya (North-Western State Medical University Named after Iliá Ilich Méchnikov (Rússia))
Fernández, Noemí (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Omrani, Ali S. (Hamad Medical Corporation (Doha, Qatar))
Bergantim, Rui (Centro Hospitalar e Universitário São João (Portugal))
De Jonge, Nick (Amsterdam University Medical Center (UMC))
Fouquet, Guillemette (CH Sud Francilien (França))
Navrátil, Milan (University Hospital Ostrava (República Txeca))
Abu-Zeinah, Ghaith (Weill Cornell Medicine (Nova York, Estats Units d'Amèrica))
Samarkos, Michail (Laikon Hospital (Atenas, Grècia))
Maertens, Johan (Katholieke Universiteit te Leuven (1970-))
De Ramón-Sánchez, Cristina (Hospital Universitario de Salamanca)
Guidetti, Anna (University of Milan and Fondazione IRCCS Istituto Nazionale Dei Tumori (Itàlia))
Magyari, Ferenc (University of Debrecen (Hongria))
González-López, Tomás José (Hospital Universitario de Burgos)
Lahmer, Tobias (Medizinische Klinik II (Múnic, Alemanya))
Finizio, Olimpia (AORN Cardarelli (Itàlia))
Ali, Natasha (Aga Khan University (Karachi, Pakistan))
Pinczés, Laszlo Imre (University of Debrecen (Hongria))
Lavilla-Rubira, Esperanza (Hospital Universitario Lucus Augusti (Lugo))
Romano, Alessandra (AOU Policlinico Rodolico San Marco (Itàlia))
Merelli, Maria (Azienda Sanitaria Universitaria del Friuli Centrale (Itàlia))
Delia, Mario (AOUC Policlinico (Bari, Itàlia))
Calbacho, Maria (Hospital 12 de Octubre (Madrid))
Meletiadis, Joseph (National and Kapodistrian University of Athens (Grècia))
Antić, Darko (University Clinical Center of Serbia (Belgrad, Sèrbia))
Hernández Rivas, José Ángel (Hospital Universitario Infanta Leonor)
Marques de Almeida, Joyce (Istituto Oncologico della Svizzera Italiana (Bellinzona, Suïssa))
Al-Khabori, Murtadha (Sultan Qaboos University Hospital (Oman))
Hoenigl, Martin (BioTechMed (Àustria))
Tisi, Maria Chiara (San Bortolo Hospital (Itàlia))
Khanna, Nina (University Hospital Basel (Basilea, Suïssa))
Barać, Aleksandra (University Clinical Center of Serbia (Belgrad, Sèrbia))
Eisa, Noha (Oncology Center Mansoura University (Aràbia, Saudita))
Di Blasi, Roberta (Hôpital Saint-Louis (París, França))
Liévin, Raphaël (Hôpital Saint-Louis (París, França))
Miranda-Castillo, Carolina (Hospital Universitario Rey Juan Carlos (Madrid))
Bahr, Nathan C. (University of Kansas Medical Center (Estats Units d'Amèrica))
Lamure, Sylvain (University of Montpellier (França))
Papa, Mario Virgilio (Azienda Ospedaliera Sant'Anna e San Sebastiano (Caserta, Itàlia))
Yahya, Ayel (Aseer Central Hospital (Aràbia Saudita))
Aujayeb, Avinash (Northumbria Healthcare (Regne Unit))
Novák, Jan (University Hospital of Královské Vinohrady (República Txeca))
Erben, Nurettin (Faculty of Medicine Eskisehir Osmangazi University (Turquia))
Fernández-Galán, María (Hospital Universitario Virgen del Puerto (Plasència, Extremadura))
Ribera-Santa Susana, Jose-María (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rinaldi, Ikhwan (Cipto Mangunkusumo General Hospital (Jakarta, Indonesia))
Fazzi, Rita (Osperadiela University Pisana Company (Itàlia))
Piedimonte, Monica (Università degli Studi di Roma "La Sapienza")
Duléry, Rémy (Sorbonne Université (França))
Gonzaga, Yung (Instituto Nacional do Cancer (Brasil))
Soto-Silva, Andrés (Universidad de Chile)
Sapienza, Giuseppe (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello (Itàlia))
Serris, Alexandra (Necker-Enfants Malades Hospitals (França))
Drgoňa, Ľuboš (Comenius University and National Cancer Institute (Bratislava, Eslovàquia))
Groh, Ana (Universitätsklinikum Frankfurt am Main (Alemanya))
Serrano, Laura (Hospital Universitario de Cabueñes (Gijón))
Gavriilaki, Eleni (George Papanicolaou General Hospital (Tessalònica, Grècia))
Tragiannidis, Athanasios (George Papanicolaou General Hospital (Tessalònica, Grècia))
Prattes, Juergen (Medical University of Graz (Àustria))
Coppola, Nicola (University of Campania (Itàlia))
Otasevic, Vladimir (University Clinical Center of Serbia (Belgrad, Sèrbia))
Mladenović, Milos (COVID Hospital "Batajnica")
Mitrović, Mirjana (University Clinical Center of Serbia (Belgrad, Sèrbia))
Mišković, Bojana (University Clinical Center of Serbia (Belgrad, Sèrbia))
Jindra, Pavel (University Hospital Pilsen (República Txeca))
Zompi, Sofia (AOU Città della Salute e della Scienza di Torino)
Sacchi, Maria Vittoria (Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo (Itàlia))
Krekeler, Carolin (University Hospital of Münster (Alemanya))
Infante, María (Hospital Universitario Infanta Leonor)
García-Bordallo, Daniel (Hospital Universitario Lucus Augusti (Lugo))
Çolak, Gökçe Melis (Marmara University (Turquia))
Mayer, Jiří (University Hospital Brno (República Txeca))
Nygaard, Marietta (Zealand University Hospital (Dinamarca))
Hanáková, Michaela (Masaryk University (República Txeca))
Ráčil, Zdeněk (Masaryk University (República Txeca))
Bonanni, Matteo (Università Cattolica del Sacro Cuore (Itàlia))
Koehler, Philipp (University of Cologne)
Rahimli, Laman (University of Cologne)
Cornely, Oliver A. (University of Cologne)
Pagano, Livio (Università Cattolica del Sacro Cuore)
EPICOVIDEHA registry
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Background: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. Methods: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide. It spans various global locations, allowing comprehensive analysis over the first three years (2020-2022). Findings: The EPICOVIDEHA registry collected data from January 2020 to December 2022, involving 8767 COVID-19 cases in hematological malignancy patients from 152 centers across 41 countries, with 42% being female. Over this period, there was a significant reduction in critical infections and an overall decrease in mortality from 29% to 4%. However, hospitalization, particularly in the ICU, remained associated with higher mortality rates. Factors contributing to increased mortality included age, multiple comorbidities, active malignancy at COVID-19 onset, pulmonary symptoms, and hospitalization. On the positive side, vaccination with one to two doses or three or more doses, as well as encountering COVID-19 in 2022, were associated with improved survival. Interpretation: Patients with hematological malignancies still face elevated risks, despite reductions in critical infections and overall mortality rates over time. Hospitalization, especially in ICUs, remains a significant concern. The study underscores the importance of vaccination and the timing of COVID-19 exposure in 2022 for enhanced survival in this patient group. Ongoing monitoring and targeted interventions are essential to support this vulnerable population, emphasizing the critical role of timely diagnosis and prompt treatment in preventing severe COVID-19 cases. Funding: Not applicable.
Ajuts:	Instituto de Salud Carlos III RHRH042953 Instituto de Salud Carlos III CM23/00277
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	COVID-19 ; Haematological malignancy ; ICU ; Immunosuppression ; Vaccination
Publicat a:	EClinicalMedicine, Vol. 71 (may 2024) , p. 102553, ISSN 2589-5370

DOI: 10.1016/j.eclinm.2024.102553
PMID: 38533127

20 p, 3.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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