Vitamin D Deficiency Is Associated with Advanced Liver Fibrosis and Impaired Fasting Glucose in Alcohol Use Disorder
Zuluaga Blanco, Yenny Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Casado-Carbajo, Julia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hernandez-Rubio, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bueno-Vélez, Marvin (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Martin, Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muga, Robert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2024
Resum:	Background: Vitamin D deficiency is a risk factor for liver disease, insulin resistance, and beta cell dysfunction. Individuals with alcohol use disorder (AUD) have many comorbidities, with a heavy burden of liver disease and metabolic complications, including type 2 diabetes mellitus (T2DM). Objective: We aimed to analyze the prevalence and associations of vitamin D deficiency in patients admitted for in-hospital treatment of AUD. Methods: A cross-sectional study was conducted in patients consecutively admitted for the treatment of AUD between January 2017 and October 2023. Sociodemographic data, substance use characteristics, and blood parameters were available at admission. Vitamin D status was assessed through the serum concentrations of 25-hydroxyvitamin D [25(OH)D] levels using a direct competitive chemiluminescent immunoassay method. Deficiency of vitamin D was defined as a concentration less than 20 ng/mL; impaired fasting glucose (IFG) was defined by fasting blood glucose >100 mg/dL (5. 6 mmol/L), and advanced liver fibrosis by an FIB-4 index >3. 25. Results: Two hundred and forty-three patients were included (75% male) with a mean age of 49 ± 10 years, mean BMI of 26. 4 ± 7. 3, mean alcohol consumption of 163 ± 81 g/day, and a mean duration of AUD of 18. 1 ± 11. 2 years. Mean 25(OH)D, fasting blood glucose, AST, ALT, and platelets were 14. 4 ± 10. 2 ng/mL, 103. 4 ± 40. 9 mg/dL, 55. 1 ± 75. 8 U/L, 44. 8 ± 76. 6 U/L, and 206. 3 ± 84. 8 × 10/L, respectively. The prevalence of vitamin D deficiency was 80. 6%, and 41. 1% of patients had levels less than 10 ng/mL. IFG was present in 32. 3% of patients, and 20. 5% had FIB-4 values >3. 25. In the multivariable analysis, IFG (OR, 2. 51; 95% CI: 1. 02-6. 17, p = 0. 04) and advanced liver fibrosis (OR, 4. 27; 95% CI: 1. 21-15. 0, p = 0. 02) were the only factors associated with vitamin D deficiency. Conclusions: Vitamin D deficiency was very prevalent in this series of patients with AUD and was associated with impaired fasting glucose and advanced liver fibrosis.
Ajuts:	Instituto de Salud Carlos III PI20/00883 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00945
Nota:	Altres ajuts: Programa Juan Rodes JR20/00016; Programa Sara Borrell CD19/00019; Red de Investigación en Atención Primaria de Adicciones (RD21/0009/0004)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Vitamin D ; Alcohol use disorder ; Fasting glucose ; Advanced liver fibrosis
Publicat a:	Nutrients, Vol. 16 Núm. 8 (April 2024) , ISSN 2072-6643

DOI: 10.3390/nu16081099
PMID: 38674789

10 p, 272.1 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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