Unveiling the Evolutionary History of European Vipers and Their Venoms From a Multi-Omic Approach
Talavera, Adrián (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Palmada-Flores, Marc (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Martínez-Freiría, Fernando (Universidade do Porto)
Mochales-Riaño, Gabriel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Burriel-Carranza, Bernat (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Estarellas, Maria (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Fernández-Guiberteau, Daniel (Centre de Recerca i Educació Ambiental de Calafell)
Camina, Álvaro (Grupo Atrox (Madrid))
Ursenbacher, Sylvain (University of Basel)
Vörös, Judit (Balaton Limnological Research Institute)
Halpern, Bálint (Eötvös Loránd University)
Pla, Davinia (Evolutionary and Translational Venomics Laboratory)
Calvete, Juan José (Evolutionary and Translational Venomics Laboratory)
Mikheyev, Alexander S. (Australian National University)
Marquès i Bonet, Tomàs 1975- (Institut Català de Paleontologia Miquel Crusafont)
Carranza, Salvador (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))

Data:	2025
Resum:	Snake genomes attract significant attention from multiple disciplines, including medicine, drug bioprospection, and evolutionary biology. However, genomic research within the Viperidae family has mostly focused on the subfamily Crotalinae, while the true vipers (Viperinae) have largely been overlooked. European vipers (Vipera) have been the subject of extensive research due to their phylogeographic and ecological diversification, as well as their venoms. Nevertheless, phylogeography and systematics in this genus have primarily relied on biased information from mitochondrial genes, which fail to capture the likely effects of introgression and are prone to biases. On the other hand, venom research in this group has been conducted predominantly through proteomics alone. In this study, we generated chromosome-level genome assemblies for three Vipera species and whole-genome sequencing data for 94 samples representing 15 Vipera lineages. This comprehensive dataset allowed us to disentangle the phylogenomic relationships of this genus, affected by mito-nuclear discordance and pervaded by ancestral introgression. Population-level analyses in the Iberian Peninsula, where the three oldest lineages within Vipera meet, revealed signals of recent adaptive introgression between old-diverged and ecologically dissimilar species, whereas chromosomal rearrangements isolate species occupying similar niches. Finally, using transcriptomic and proteomic data, we characterised the Vipera toxin-encoding genes, in which opposing selective forces were unveiled as common drivers of the evolution of venom as an integrated phenotype.
Ajuts:	Agencia Estatal de Investigación PID2021-128901NB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00420 "la Caixa" Foundation LCF/BQ/DR20/11790007 "la Caixa" Foundation LCF/BQ/DR20/11790032 Ministerio de Ciencia, Innovación y Universidades FPU18/04742 Ministerio de Ciencia, Innovación y Universidades PRE2019-088729 Ministerio de Ciencia, Innovación y Universidades PRE2022-101473
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Molecular ecology, (July 2025) , art. e70019, ISSN 1365-294X

DOI: 10.1111/mec.70019
PMID: 40650520

16 p, 4.7 MB

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