Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
Gayete Lafuente, Sònia (Foundation for Reproductive Medicine)
Moreno-Sepulveda, José (Clínica de La Mujer Medicina Reproductiva, Viña del Mar)
Sánchez-Álvarez, Javier (Hospital Universitari Vall d'Hebron)
Prat Grau, Maria (Hospital del Mar (Barcelona, Catalunya))
Robles, Ana (Hospital del Mar (Barcelona, Catalunya))
Espinós, Juan José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Checa, Miguel Angel (Hospital del Mar (Barcelona, Catalunya))

Data:	2024
Resum:	Purpose: To evaluate the predictive value of serum AMH for clinical pregnancy in non-infertile population undergoing intrauterine insemination with donor sperm (ds-IUI). Methods: This multicenter prospective study (ClinicalTrials. gov ID: NCT06263192) recruited all non-infertile women undergoing ds-IUI from June 2020 to December 2022 in three different fertility clinics in Spain and Chile. Indications for ds-IUI included severe oligoasthenoteratozoospermia, female partner, or single status. Clinical pregnancy rates were compared between women with AMH ≥ 1. 1 and < 1. 1 ng/mL. The main outcome measure was the cumulative clinical pregnancy rate after up to 4 ds-IUI cycles. Results: A total of 458 ds-IUI cycles were performed among 245 patients, of whom 108 (44. 08%) achieved clinical pregnancy within 4 cycles, 60. 2% of these occurring in the first attempt and 84. 2% after two attempts. We found no significant differences in AMH levels or other parameters (such as age, BMI, FSH, AFC) between women who became pregnant and those who did not. Cumulative pregnancy rates and logistic regression analysis revealed that AMH ≥ 1. 1 ng/mL was not predictive of ds-IUI success. While a high positive correlation was observed between AFC and AMH (r = 0. 67, p < 0. 001), ROC curve analyses indicated that neither of these ovarian reserve markers accurately forecasts cumulative ds-IUI outcomes in non-infertile women. Conclusions: The findings of this multicenter study suggest that AMH is not a reliable predictor of pregnancy in non-infertile women undergoing ds-IUI. Even women with low AMH levels can achieve successful pregnancy outcomes, supporting the notion that diminished ovarian reserve should not restrict access to ds-IUI treatments in eligible non-infertile women.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	AMH ; Anti-Müllerian hormone ; Cumulative pregnancy rate ; IUI ; Intrauterine insemination ; Predictive value
Publicat a:	Journal of assisted reproduction and genetics, Vol. 41 Núm. 9 (September 2024) , ISSN 1573-7330

DOI: 10.1007/s10815-024-03188-5
PMID: 38987421

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