Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms : a pilot study
Painous, Cèlia (Hospital Clínic i Provincial de Barcelona)
Pascual-Diaz, Saül (Universitat de Barcelona)
Muñoz-Moreno, E. (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Sánchez, V. (Hospital Clínic i Provincial de Barcelona)
Pariente, JC. (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Prats-Galino, Alberto (Hospital Clínic i Provincial de Barcelona)
Soto, M. (Hospital Clínic i Provincial de Barcelona)
Fernández, M. (Hospital Clínic i Provincial de Barcelona)
Pérez-Soriano, A. (Hospital Clínic i Provincial de Barcelona)
Camara, A. (Hospital Clínic i Provincial de Barcelona)
Muñoz, E. (Hospital Clínic i Provincial de Barcelona)
Valldeoriola, F. (Hospital Clínic i Provincial de Barcelona)
Caballol, N. (Hospital de Sant Joan Despí Moisès Broggi)
Pont-Sunyer, C. (Universitat Internacional de Catalunya)
Martin, N. (Hospital Clínic i Provincial de Barcelona)
Basora, Misericordia (Hospital Clínic i Provincial de Barcelona)
Tio, M. (Hospital Clínic i Provincial de Barcelona)
Ríos, José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Martí, MJ. (Hospital Clínic i Provincial de Barcelona)
Bargalló, N. (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Compta, Y. (Hospital Clínic i Provincial de Barcelona)

Data:	2023
Resum:	To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association with clinical and cerebrospinal fluid (CSF) correlates. We collected demographic and clinical variables, performed planimetric and shape MRI analyses, and determined CSF neurofilament-light chain (NfL) levels in 84 participants: 11 CS, 12 with Parkinson's disease (PD), 26 with multiple system atrophy (MSA), 21 with progressive supranuclear palsy (PSP), and 14 with corticobasal degeneration (CBD). MSA featured the most extensive and significant brainstem shape narrowing (that is, atrophy), mostly in the pons. CBD presented local atrophy in several small areas in the pons and midbrain compared to PD and CS. PSP presented local atrophy in small areas in the posterior and upper midbrain as well as the rostral pons compared to MSA. Our findings of planimetric MRI measurements and CSF NfL levels replicated those from previous literature. Brainstem shape atrophy correlated with worse motor state in all parkinsonisms and with higher NfL levels in MSA, PSP, and PD. Atypical parkinsonisms present different brainstem shape patterns which correlate with clinical severity and neuronal degeneration. In MSA, shape analysis could be further explored as a potential diagnostic biomarker. By contrast, shape analysis appears to have a rather limited discriminant value in PSP. • Atypical parkinsonisms present different brainstem shape patterns. • Shape patterns correlate with clinical severity and neuronal degeneration. • In MSA, shape analysis could be further explored as a potential diagnostic biomarker. The online version contains supplementary material available at 10. 1007/s00330-023-09435-0.
Ajuts:	Instituto de Salud Carlos III PI17/00096 Instituto de Salud Carlos III CM18/00072
Nota:	Altres ajuts: Fundació La Marató de TV3 (PI043296); PERIS program (SLT008/18/00191)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multiple system atrophy ; Progressive supranuclear palsy ; Shape analysis ; Neurofilament protein ; Parkinsonian disorders
Publicat a:	European radiology, Vol. 33 Num. 7 (February 2023) , p. 4540-4551, ISSN 1432-1084

DOI: 10.1007/s00330-023-09435-0
PMID: 36773046

12 p, 1.3 MB

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