Profile of Cytokines Associated with SARS-CoV2 Seropositivity in Multiple Sclerosis Patients and Its Persistence over Six Months
Sancho-Saldaña, Agustín (Hospital Arnau de Vilanova (Lleida, Catalunya))
Gil Sánchez, Anna (Institut de Recerca Biomèdica de Lleida-IRBLleida)
Quirant, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Boigues Pons, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Peralta, Silvia (Institut de Recerca Biomèdica de Lleida-IRBLleida)
Solana, Maria José (Hospital Arnau de Vilanova (Lleida, Catalunya))
González-Mingot, Cristina (Hospital Arnau de Vilanova (Lleida, Catalunya))
Quibus, Laura (Institut de Recerca Biomèdica de Lleida-IRBLleida)
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Torres, Pascual (Institut de Recerca Biomèdica de Lleida-IRBLleida)
Hervas-Garcia, Jose Vicente (Hospital de Sant Joan Despí Moisès Broggi)
Moreno, Judith (Institut de Recerca Biomèdica de Lleida-IRBLleida)
Brieva Ruiz, Luis (Hospital Arnau de Vilanova (Lleida, Catalunya))

Data:	2025
Resum:	Background: Patients with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs) may exhibit altered immune responses to infections such as SARS-CoV-2. This study aimed to characterize the cytokine profiles associated with prior SARS-CoV-2 infection and to identify immune markers related to the persistence of the humoral response in pwMS. Methods: A total of 90 pwMS were recruited before the introduction of COVID-19 vaccination in Spain; 46 were seropositive-defined by the presence of IgG, IgM, or IgA antibodies against SARS-CoV-2-and 44 were seronegative. We compared baseline cytokine levels between groups and followed seropositive individuals for six months to assess IgG antibody persistence. Results: Seropositive patients showed significantly lower baseline levels of IL-10, IL-23, and IFN-α compared to seronegative individuals. Notably, elevated IL-18 at baseline was associated with persistent IgG seropositivity at six months. Conclusions: These findings suggest a distinct cytokine profile in SARS-CoV-2-exposed pwMS and highlight IL-18 as a potential marker of sustained humoral response. This study provides insight into host-virus immune dynamics in MS patients and may help guide future strategies for infection monitoring and immune evaluation in this population.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multiple sclerosis ; SARS-CoV-2 ; Cytokines ; Seropositivity ; IL-18 ; Disease-modifying therapies
Publicat a:	Journal of clinical medicine, Vol. 14, Núm. 11 (May 2025) , ISSN 2077-0383

DOI: 10.3390/jcm14113736
PMID: 40507498

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