Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management : A New Paradigm in Regenerative Wound Care
Fonseca Canteros, Marcelo Andres (Universitat Autònoma de Barcelona)
Cañete, Aldo (Dr. Ernesto Torres Galdames Hospital)
Mandriaza, Luana (Tarapacá Skin and Tissue Bank)
Gómez, Jennifer (Dr. Ernesto Torres Galdames Hospital)
Masiá, Jaime (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Marcelain, Katherine (Universidad de Chile)
Ibaceta, Dino (Tarapacá Skin and Tissue Bank)
Erazo, Cristian (Universidad de Chile)
Gámez, Brenda (Universidad de Chile)
Rius, Monserrat (Universidad del Desarrollo)
Disi, Florencia (Dr. Ernesto Torres Galdames Hospital)

Data:	2025
Resum:	Skin allografts are essential in managing complex wounds, yet their availability is limited by low post-mortem donation rates. Skin harvested during body contouring surgeries offers a novel and sustainable source to expand tissue supply. We conducted a retrospective descriptive study at the Tarapacá Skin and Tissue Bank from January 2022 to December 2024. All donations from body contouring surgeries were processed as cryopreserved total skin allografts following national tissue banking standards. Variables included donor demographics, harvested area, units produced, microbiological results, and discard rates. To describe clinical performance, we present our group's initial clinical series of treated patients. From 248 living donors (mean age 41. 3 years), 81 293 cm 2 of skin generated 2050 units. The discard rate was 27%, mainly due to a storage failure and isolated microbial contamination. Clinically, all patients achieved complete initial graft take, followed by gradual necrotic eschar formation at an average of 21 days. Eschar removal revealed vital tissue firmly adhered to the recipient bed, rich in fibroblasts and neovascular structures. Subsequent management included either escharectomy with split-thickness autografting over the neodermis, or spontaneous eschar lysis and skin regeneration, with the graft functioning as a dermal regenerator. This model increases tissue availability while providing allografts with both coverage and dermal regenerative properties.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Skin allograft ; Tissue banks ; Wound healing
Publicat a:	International Wound Journal, Vol. 22 Num. 9 (September 2025) , ISSN 1742-481X

DOI: 10.1111/iwj.70759
PMID: 40890023

14 p, 3.0 MB

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