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| Pàgina inicial > Articles > Articles publicats > Neural correlates of human fear conditioning and sources of variability in 2199 individuals |
(Universitat de Barcelona) (The University of Melbourne) (Leuven Brain Institute) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (University Hospital Bonn (Bonn, Alemanya)) (Ruhr University) (University of Manitoba) (Vanderbilt University) (University of Florida) (University of Amsterdam) (Technical University of Munich) (Duke University) (University of Wisconsin-Milwaukee) (University Medical Center Hamburg Eppendorf) (Ruhr University Bochum) (University of Oregon) (University of Reading) (University of Maryland) (Institut d'Investigació Biomèdica de Bellvitge) (University of Marburg) (University of Amsterdam) (University of Florida) (University of Münster) (Pontifical Catholic University) (Universidade de São Paulo) (Institut de Recerca Sant Pau) (Institut d'Investigació Biomèdica de Bellvitge) (University of Texas at Austin) (University of Münster) (Universitat de Barcelona) (Harvard University) (Medical Center - University of Freiburg) (Duke University) (Julius-Maximilians-Universität Würzburg) (University of Arizona) (University of Münster) (University of Marburg) (Bielefeld University, Medical School and University Medical Center OWL) (Harvard Medical School) (Ruhr University) (University Medicine Greifswald) (Humboldt-Universität zu Berlin) (Ruhr-University Bochum (FBZ) and German Center for Mental Health (DZPG)) (Institut d'Investigació Biomèdica de Bellvitge) (University of Southampton) (Institut d'Investigacions Biomèdiques August Pi i Sunyer) (University of Göttingen) (Institut de Recerca Sant Pau) (University of Hildesheim) (University of Marburg) (University of Osnabrück) (Karolinska Institutet) (Charité-Universitätsmedizin Berlin) (University of Rochester) (Ulm University Clinic) (Ludwig-Maximilians-University München) (Charité-Universitätsmedizin Berlin) (Charité-Universitätsmedizin Berlin) (University of Southern California) (Leiden University Medical Center) (University of Cape Town) (University of Cape Town) (University of Texas at Austin) (Radboud University Medical Centre) (Hospital Clínic i Provincial de Barcelona)
| Data: | 2025 |
| Resum: | Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the "central autonomic-interoceptive" or "salience" network. Several task variables strongly modulate activity in these regions, contributing to variability in neural responses. Additionally, brain activation patterns differ between healthy individuals and those with anxiety-related or depressive disorders, with distinct profiles characterizing specific disorders such as post-traumatic stress disorder and obsessive-compulsive disorder. While the neural correlates of fear conditioning are highly generalizable at the population level, variability arises from differences in task design and clinical status, highlighting the importance of methodological diversity in capturing fear learning mechanisms. |
| Ajuts: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01128 Ministerio de Economía y Competitividad PI16/00889 Instituto de Salud Carlos III PI19/01171 Instituto de Salud Carlos III PI22/00219 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01017 Agencia Estatal de Investigación PID2022-139081OB-C22 "la Caixa" Foundation LCF/BQ/IN17/11620071 |
| Nota: | Altres ajuts: National Institute of Mental Health (No. R01MH119132 and MH108753, J.C.; R01MH095904 and K23MH076054, D.J.H.; R01MH125615, A.K.; R01-MH103291, K.A.M.; 1R61MH129559-02, Y.N.; R01-AA031261, A.S.; K01MH122774, X.Z.; R01MH131532, B.S.J; R01MH125615, L.A.), the German Research Foundation (No. 316803389 - SFB 1280, S.E., C.J.M. and A.I.; LO 1980/1-1 and CRC-TRR58 subproject B07, T.B.L.; LO 1980/4-1, T.B.L. and M.R.E.; 521379614 - TRR393, B.S., U.D. and T.K.; 44541416 CRC-TRR58 T.S., K.R., K.D. and M.J.; 442075332 (RU 5187) and 461947532 (RU 5389), U.L.; WA 1539/11-1, H.W.;), the Economic and Social Research Council UK (No. ES/W000776/1, D.B.), the NSERC Discovery (No.RGPIN-2021-02906, S.G.), the National Institute of Health (No. R01 MH106574, C.L.; R01 MH122387, J.D.), the United states-Israel binational science foundation and NIA (No.2P30AG064198, Y.N.), the National Institute of Mental Health Intramural Research (No. ZIA-MH-002781, D.P.), the Biotechnology and Biological Sciences Research Council (No. BB/L02697X/1, C.vR.), NIAAA (No. R01-AA030042, A.S.); Fundació Marató de TV3 (No.202201-31, C.S.M.) |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Neural circuits ; Fear conditioning |
| Publicat a: | Nature communications, Vol. 16 Núm. 1 (August 2025) , ISSN 2041-1723 |
