Clinical significance of blood cell ratios in healthy and sick Leishmania infantum -seropositive dogs
Donato, Giulia (Università di Messina)
Baxarias, Marta (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Martínez-Flórez, Icíar (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Mateu, Cristina (Ecuphar Veterinaria SLU)
Pennisi, Maria Grazia (ASC "I Periodeuti")

Data:	2024
Resum:	The accuracy of blood cell ratios (BCRs) as cost-effective and easily accessible diagnostic and prognostic markers of inflammatory conditions has been investigated in veterinary medicine in recent years. Neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) ratios were studied in 195 dogs clinically evaluated and tested for anti- Leishmania infantum (Li) antibodies (Li -seronegative (Li -), n = 10; Li -seropositive clinically healthy (Li + ), n = 100; Li -seropositive with clinical and/or clinicopathological abnormalities (Li + ), n = 85). The Li + dogs were classified in LeishVet stages IIa/IIb (Li + ) (n = 66) and III/IV (Li + ) (n = 19). BCR relationships with LeishVet clinical stage, antibody levels, and serum protein electrophoretic fraction concentrations were investigated. Higher NLR values were found in Li +, Li + , and Li + sick dogs compared to Li - dogs (P < 0. 001). Higher NLR and MLR were found in Li + (NLR, P < 0. 001; MLR, P = 0. 034) and Li + dogs (NLR, P < 0. 001; MLR, P = 0. 005) compared to Li - dogs, and in Li + dogs (NLR, P = 0. 002; MLR, P < 0. 001) compared to Li + . All three BCRs were higher in Li + (NLR, MLR, P < 0. 001; PLR, P = 0. 023) and Li + dogs (NLR P < 0. 001; MLR P = 0. 001; PLR, P = 0. 012) compared to Li + dogs. The BCRs failed to distinguish dogs with moderate (Li + ) and severe or very severe disease (Li + ). BCRs demonstrated weak positive correlations with serum globulin fractions and antibody levels, and weak negative correlations with serum albumin level were found. Li + dogs presenting hypoalbuminemia showed higher MLR ratios (P = 0. 001) than those with normal albumin values. This study shows that BCR measures provide useful information for differentiating antibody-positive healthy and sick dogs at diagnosis. Dogs with hypoalbuminemia showed higher MLR values despite monocytosis being very rare. The online version contains supplementary material available at 10. 1186/s13071-024-06522-z.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Canine leishmaniosis ; Serum protein electrophoresis ; Neutrophil-to-lymphocyte ratio ; Monocyte-to-lymphocyte ratio ; Platelet-to-lymphocyte ratio ; Clinical staging and LeishVet
Publicat a:	Parasites & vectors, Vol. 17 (october 2024) , ISSN 1756-3305

DOI: 10.1186/s13071-024-06522-z
PMID: 39444011

8 p, 863.8 KB

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