A Bioactive Extract Rich in Triterpenic Acid and Polyphenols from Olea europaea Promotes Systemic Immunity and Protects Atlantic Salmon Smolts Against Furunculosis
Salomón, Ricardo (Universitat Autònoma de Barcelona)
Furones, M. Dolors (Institut de Recerca i Tecnologia Agroalimentàries)
Reyes Lopez, Felipe Esteban (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Firmino, Joana P. (Institut de Recerca i Tecnologia Agroalimentàries)
Esteban, María Ángeles (Universidad de Murcia)
Espinosa Ruíz, Cristóbal (Universidad de Murcia)
Quintela, José C. (Natac Biotech (Alcorcón, Madrid))
Pinilla-Rosas, José M. (Natac Biotech (Alcorcón, Madrid))
Vallejos Vidal, Eva Carolina (Universidad de Santiago de Chile)
Gisbert, Enric (Institut de Recerca i Tecnologia Agroalimentàries)

Data:	2021
Resum:	In the present study, the modulation of the transcriptional immune response (microarray analysis) in the head kidney (HK) of the anadromous fish Atlantic salmon (Salmo salar) fed a diet supplemented with an olive fruit extract (AQUOLIVE ®) was evaluated. At the end of the trial (133 days), in order to investigate the immunomodulatory properties of the phytogenic tested against a bacterial infection, an in vivo challenge with Aeromonas salmonicida was performed. A total number of 1,027 differentially expressed genes (DEGs) (805 up- and 222 downregulated) were found when comparing the transcriptomic profiling of the HK from fish fed the control and AQUOLIVE ® diets. The HK transcripteractome revealed an expression profile that mainly favored biological processes related to immunity. Particularly, the signaling of i-kappa B kinase/NF-kappa and the activation of leukocytes, such as granulocytes and neutrophils degranulation, were suggested to be the primary actors of the innate immune response promoted by the tested functional feed additive in the HK. Moreover, the bacterial challenge with A. salmonicida that lasted 12 days showed that the cumulative survival was higher in fish fed the AQUOLIVE ® diet (96. 9 ± 6. 4%) than the control group (60. 7 ± 13. 5%). These results indicate that the dietary supplementation of AQUOLIVE ® at the level of 0. 15% enhanced the systemic immune response and reduced the A. salmonicida cumulative mortality in Atlantic salmon smolts.
Ajuts:	European Commission 830202 Generalitat de Catalunya 2017DI017
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Feed additive ; Olea europaea ; Aquaculture ; Aeromonas salmonicida ; Challenge ; Systemic immunity ; Salmo salar ; Immune homeostasis
Publicat a:	Frontiers in immunology, Vol. 12 (november 2021) , ISSN 1664-3224

DOI: 10.3389/fimmu.2021.737601
PMID: 34867959

18 p, 5.5 MB

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