Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval
Costa, Manuela (Universidad Politécnica de Madrid. Centro de Tecnología Biomédica)
Pacheco Estefan, Daniel (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Gil-Nagel, Antonio (Hospital Ruber Internacional. Departamento de neurología)
Toledano, Rafael (Hospital Ruber Internacional. Hospital Ruber Internacional. Departamento de neurología)
Imbach, Lukas (University Zurich)
Sarnthein, Johannes (University of Zurich)
Strange, Bryan A. (Universidad Politécnica de Madrid. Centro de Tecnología Biomédica)

Data:	2025
Resum:	Emotional memories require coordinated activity of the amygdala and hippocampus. Human intracranial recordings have shown that formation of aversive memories involves an amygdala theta-hippocampal gamma phase code. Yet, the mechanisms engaged during translation of aversive experiences into memories and subsequent retrieval remain unclear. Directly recording from human amygdala and hippocampus, here we show that hippocampal gamma activity increases for correctly remembered aversive scenes. Crucially, patterns of amygdala high amplitude gamma activity at encoding are reactivated in the hippocampus, but not amygdala, during both aversive encoding and retrieval. Trial-specific hippocampal gamma patterns showing highest representational similarity with amygdala activity at encoding are reactivated in the hippocampus during aversive retrieval. This reactivation process occurs against a background of gamma activity that is otherwise decorrelated between encoding and retrieval. Thus, phasic hippocampal gamma responses track the retrieval of aversive memories, with activity patterns apparently entrained by the amygdala during encoding.
Ajuts:	European Commission 819814
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Amygdala ; Hippocampus
Publicat a:	Nature communications, Vol. 16, art. 6820 (july 2025) , ISSN 2041-1723

DOI: 10.1038/s41467-025-61928-2
PMID: 40707435

14 p, 4.0 MB

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