Increased copeptin may reflect vasopressin-related metabolic changes after bariatric surgery
Galbiati, F. (Harvard Medical School)
Becetti, I. (Harvard Medical School)
Lauze, M. (Harvard Medical School)
Aulinas, Anna (Institut de Recerca Sant Pau)
Singhal, V. (Mattel Childrens' Hospital)
Bredella, M.A. (NYU Langone Health and Grossman School of Medicine)
Lawson, E.A. (Harvard Medical School)
Misra, M. (University of Virginia)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	Objective: Mechanisms underlying metabolic improvement following metabolic and bariatric surgery (MBS) may provide insight into novel therapies. Vasopressin improves body composition and protects against hypoglycemia. Associations of copeptin, a stable cleavage product of vasopressin, with BMI and insulin resistance suggest an adaptive increase in vasopressin to counteract metabolic disruption. To our knowledge, no study has investigated copeptin before and after MBS in humans. This study's aim was to investigate copeptin changes following MBS and associations with metabolic parameters. Methods: This was a 12-month longitudinal study of 64 youth (78% female; mean age 18. 7 [SD 2. 8] y) with obesity (mean BMI 45. 6 [SD 6. 8] kg/m) undergoing MBS (n = 34) or nonsurgical (NS) lifestyle management (n = 30). Fasting copeptin, hemoglobin A1c (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), body composition, and resting energy expenditure (REE) were assessed. Results: Over 12 months, copeptin increased more (time-by-treatment p = 0. 017) whereas HbA1c and adiposity decreased more after MBS than NS (ps ≤ 0. 036). Copeptin changes correlated negatively with percentage fat mass and REE changes (rho ≤ -0. 29; ps ≤ 0. 025) in the whole group, and they correlated positively with HbA1c and HOMA-IR (rho ≥ 0. 41; false discovery rate-adjusted p = 0. 05) and negatively with REE changes (rho = -0. 55; false discovery rate-adjusted p = 0. 036) in the MBS group. Conclusions: Increases in copeptin after weight loss in MBS compared with NS were associated with lower REE and higher HbA1c/HOMA-IR values. Vasopressin may contribute to MBS-related metabolic modifications.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adiposity ; Adolescent ; Bariatric Surgery ; Body Composition ; Body Mass Index ; Energy Metabolism ; Female ; Glycated Hemoglobin ; Glycopeptides ; Humans ; Insulin Resistance ; Longitudinal Studies ; Male ; Obesity ; Vasopressins ; Weight Loss ; Young Adult
Publicat a:	Obesity, Vol. 33 Núm. 2 (february 2025) , p. 298-307, ISSN 1930-739X

DOI: 10.1002/oby.24200
PMID: 39725569

10 p, 1.7 MB

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